gene

CLN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

7Outgoing

1Incoming

0Experiments

0Debates

Summary

CLN1 (PPT1) — Palmitoyl-Protein Thioesterase 1

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🧬 Gene Info

Gene Symbol	CLN1
Full Name	Palmitoyl-Protein Thioesterase 1
Chromosome	1p34.2
Protein Type	Enzyme
Function	encodes a protein of 306 amino acids with a molecular weight of approximately 34 kDa.
Primary Expression	neurons and regulates synaptic vesicle proteins[@lin2021]: - Synaptic vesicle cycling: Removes palmitoyl groups from vesicle proteins - Neurotra
Molecular Weight	34 kDa
Amino Acids	306 aa
Exons	9
UniProt ID	O00624
NCBI Gene ID	1204
Ensembl ID	ENSG00000132128
OMIM	256000
GeneCards	CLN1
Human Protein Atlas	CLN1
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	IGF1, PI3K
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CLN1 — AlphaFold O00624 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["CLN1"]
    N1["rapamycin"]
    N1 -->|"targets"| N0
    N2["neurodegeneration"]
    N0 -->|"associated with"| N2
    N3["PPT1"]
    N0 -->|"causes"| N3
    N4["autophagy pathway"]
    N0 -->|"participates in"| N4
    N5["IGF1"]
    N0 -->|"activates"| N5
    N6["PI3K"]
    N0 -->|"activates"| N6
    N7["PI3K-AKT-mTOR signaling"]
    N0 -->|"participates in"| N7
    N8["neurons"]
    N0 -->|"expressed in"| N8

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 gene
    class N1 drug
    class N2 disease
    class N3 gene
    class N4 pathway
    class N5 gene
    class N6 gene
    class N7 pathway
    class N8 cell_type

Outgoing (7)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
neurodegeneration	associated_with	disease	0.60
PPT1	causes	gene	0.60
IGF1	activates	gene	0.60
PI3K	activates	gene	0.60
neurons	expressed_in	cell_type	0.55

Incoming (1)

Source	Relation	Type	Str
rapamycin	targets	drug	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLN1 in their description or question text

No additional research found