gene 1,496 words KG: ICAM1
Contents

ICAM1 - Intercellular Adhesion Molecule 1

🧬 Gene Info
Gene SymbolICAM1
Full NameIntercellular Adhesion Molecule 1
Chromosome19p13.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Amino Acids23 aa
UniProt IDP05362
NCBI Gene ID3383
Ensembl IDENSG00000090339
GeneCardsICAM1
Human Protein AtlasICAM1
Associated DiseasesAls, Alzheimer, Chronic Obstructive Pulmonary Disease, Fibrosis, Ms
InteractionsABCD1, ABCD2, ADAMTS1, AMPK, AND, ANXA2
KG Connections413 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (11)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Astrocytes
cell · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: therapeutic_target
ABCD1 — ATP Binding Cassette Subfamily D Member 1
gene · KG edge: inhibits
ABCD2 — ATP Binding Cassette Subfamily D Member 2
gene · KG edge: activates

Knowledge Graph (12 edges)

CRY1 activates ICAM1
BMAL1 activates ICAM1
ARNT activates ICAM1
TNF activates ICAM1
TNFRSF1A activates ICAM1
OCLN activates ICAM1
CXCL10 associated_with ICAM1
TNF associated_with ICAM1
BAX inhibits ICAM1
CXCL2 associated_with ICAM1

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