concept

DNA DAMAGE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNA DAMAGE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

293Connections

4Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

DNA DAMAGE is a concept in neurodegeneration research. Key relationships include: co discussed, activates, causes. Associated with AMYOTROPHIC LATERAL SCLEROSIS, ATAXIA, CANCER. Connected to 86 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DNA DAMAGE
Key Genes/Proteins	ACTB, ALS4, amyotrophic lateral sclerosis, AQP1, ARNTL, ASXL1
Related Diseases	aging, Ataxia, ataxia-telangiectasia

Pathway Diagram

graph TD
    DNA_DAMAGE["DNA DAMAGE"]
    DNA_DAMAGE -->|"causes"| Neuronal_Functions["Neuronal Functions"]
    DNA_DAMAGE -->|"risk_factor_for"| Neurodegeneration["Neurodegeneration"]
    DNA_DAMAGE -->|"contributes to"| Neuronal_Aging["Neuronal Aging"]
    DNA_DAMAGE -->|"modulates"| Chromatin_Topology["Chromatin Topology"]
    DNA_DAMAGE -->|"contributes to"| Follicular_Atresia["Follicular Atresia"]
    DNA_DAMAGE -->|"transports"| T_CELL["T CELL"]
    DNA_DAMAGE -->|"transports"| T_CELLS["T CELLS"]
    DNA_DAMAGE -->|"transports"| TUMOR["TUMOR"]
    DNA_DAMAGE -->|"interacts"| EGF["EGF"]
    DNA_DAMAGE -->|"interacts"| HMGB1["HMGB1"]
    DNA_DAMAGE -->|"activates"| JNK["JNK"]
    miR_139_5p_Mimic["miR-139-5p Mimic"] -->|"causes"| DNA_DAMAGE
    CSNK2A1["CSNK2A1"] -->|"regulates"| DNA_DAMAGE
    NOTCH1["NOTCH1"] -->|"regulates"| DNA_DAMAGE
    oxidative_stress["oxidative stress"] -->|"causes"| DNA_DAMAGE
    Oxidative_Stress["Oxidative Stress"] -->|"causes"| DNA_DAMAGE
    GSK2606414["GSK2606414"] -.protects against.-> DNA_DAMAGE
    TFEB["TFEB"] -->|"inhibits"| DNA_DAMAGE
    TDP_43_mislocalization["TDP-43 mislocalization"] -->|"activates"| DNA_DAMAGE
    CGAS["CGAS"] -->|"causes"| DNA_DAMAGE
    AUTOPHAGY["AUTOPHAGY"] -->|"transports"| DNA_DAMAGE
    CANCER["CANCER"] -->|"transports"| DNA_DAMAGE

Outgoing (77)

Target	Relation	Type	Str
Neurodegeneration	risk_factor_for	disease	0.95
Transcription	inhibits	process	0.95
Neuronal Functions	causes	phenotype	0.95
Transcription	associated_with	process	0.95
neuropathology	contributes_to	disease	0.90
STING Pathway	activates	pathway	0.90
aging	promotes	process	0.90
Neuronal Aging	risk_factor_for	process	0.90
KIAA0247	upregulates	gene	0.90
cGAS-STING signaling	activates	pathway	0.90
Neuroinflammation	contributes_to	process	0.90
Neuronal Aging	contributes_to	process	0.90
Apoptosis	contributes_to	process	0.90
APOPTOSIS	promotes	process	0.90
p53 Phosphorylation	activates	process	0.90
STING pathway	activates	pathway	0.87
ribosome biogenesis	modulates	process	0.85
Aging	contributes_to	process	0.85
Neuroinflammation	contributes_to	process	0.85
Chromatin Topology	associated_with	process	0.85
Genome Instability	associated_with	phenotype	0.85
Brain Aging	contributes_to	process	0.85
STING	activates	protein	0.85
Neurodegeneration	contributes_to	process	0.80
cGAS	induces	protein	0.80
Aging	causes	process	0.80
Follicular Atresia	contributes_to	process	0.80
NEURODEGENERATION	contributes_to	process	0.80
Motor Neuron Death	causes	process	0.80
oligodendrocyte degeneration	causes (DNA damage in oligodendrocytes precedes amyloid pa)	mechanism	0.75
Parkinson's disease	associated_with	disease	0.70
GENE EXPRESSION	expressed_in	concept	0.50
FRONTAL	regulates	concept	0.50
GENE EXPRESSION	regulates	concept	0.50
Telomere	activates	pathway	0.50
GENE EXPRESSION	interacts_with	concept	0.50
Dna Damage Response	interacts_with	pathway	0.50
Cellular Senescence	activates	cell_type	0.50
Telomere	inhibits	pathway	0.50
Dysbiosis	inhibits	disease	0.50
PD-L1	activates	concept	0.50
HER2	activates	concept	0.50
STEM CELLS	activates	concept	0.50
IPSC	activates	concept	0.50
Cellular Senescence	associated_with	cell_type	0.50
DENDRITIC SPINE	inhibits	concept	0.50
GLIOSIS	activates	concept	0.50
Epithelial-Mesenchymal Transition	activates	process	0.50
Tumor Microenvironment	activates	process	0.50
Dna Damage Response	regulates	pathway	0.50

Incoming (216)

Source	Relation	Type	Str
etoposide	causes	drug	0.95
SMARCAL1	inhibits	gene	0.95
cigarette smoke	causes	phenotype	0.90
Prmt Inhibition	upregulates	mechanism	0.90
SNCA	causes	protein	0.90
miR-139-5p Mimic	causes	compound	0.90
Top1 Cleavage Complexes	contributes_to	mechanism	0.90
PRMT suppression	promotes	process	0.90
R-Loop	causes	mechanism	0.90
PRMT inhibition	associated_with	process	0.88
Single-Stranded Dna	associated_with	compound	0.85
Aging	causes	process	0.85
Alpha-Synuclein	causes	protein	0.85
SNCA	causes	gene	0.85
Redox Stress	causes	process	0.85
R-Loop Deregulation	contributes_to	mechanism	0.85
SNCA	causes	protein	0.85
Single-Stranded DNA	associated_with	compound	0.85
Oxidative Stress	causes	process	0.85
GABARAPL1	protects_against	gene	0.85
PARP1	involved_in	protein	0.85
SOD1 Aggregation	contributes_to	process	0.85
SOD1	associated_with	protein	0.85
CSNK2A1	regulates	protein	0.85
NOTCH1	regulates	protein	0.85
SIRTUINS	modulates	protein	0.80
Helicobacter pylori	associated_with	entity	0.80
PARP1	traps	gene	0.80
HERV-K	causes	gene	0.80
PARP1	activates	gene	0.80
TDP-43 mislocalization	activates	process	0.70
Oxidative Stress	causes	process	0.70
TFEB	inhibits	protein	0.70
GSK2606414	protects_against	drug	0.70
oxidative stress	causes	process	0.70
MLST8	activates	gene	0.50
MAPK	activates	gene	0.50
RB1CC1	activates	gene	0.50
HMGB1	activates	gene	0.50
ASXL1	activates	gene	0.50
TP53	activates	gene	0.50
SF3B1	activates	gene	0.50
TET2	activates	gene	0.50
U2AF1	activates	gene	0.50
DNMT3A	activates	protein	0.50
inflammation	activates	pathway	0.50
AQP1	interacts_with	gene	0.50
Autophagy	associated_with	process	0.50
apoptosis	associated_with	process	0.50
NEURONS	activates	concept	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.661	neurodegeneration	What upstream mechanisms trigger p53 act
Telomere Attrition and DNA Damage Response Activation Induce	0.520	neurodegeneration	What molecular mechanisms drive microgli
Mitochondrial DNA Damage and cGAS-STING Activation Induces M	0.520	neurodegeneration	What molecular mechanisms drive microgli
DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed	0.430	neurodegeneration	How does APOE4 mechanistically increase

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.726

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What cell types are most vulnerable in Alzheimer's Disease based on SEA-AD trans

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning DNA DAMAGE in their description or question text

No additional research found