protein

NMDA RECEPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NMDA RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

175Connections

0Hypotheses

0Analyses

45Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for NMDA Receptor Protein

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🔬 Protein Info

Gene Symbol	NMDA RECEPTOR
Molecular Weight	220 kDa
Pathways	Neurodegeneration
Associated Diseases	Alzheimer
Interactions	AMPA RECEPTOR, NMDA
KG Connections	8 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    NMDA_RECEPTOR["NMDA RECEPTOR"]
    NMDA_RECEPTOR -->|"involved_in"| Neurodegeneration["Neurodegeneration"]
    NMDA_RECEPTOR -->|"mediates"| Synaptic_Plasticity["Synaptic Plasticity"]
    NMDA_RECEPTOR -->|"modulates"| ARHGEF7["ARHGEF7"]
    NMDA_RECEPTOR -->|"activates"| Als["Als"]
    NMDA_RECEPTOR -->|"activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    Memantine["Memantine"] -->|"inhibits"| NMDA_RECEPTOR
    Compound_A["Compound A"] -->|"inhibits"| NMDA_RECEPTOR
    Compound_B["Compound B"] -->|"inhibits"| NMDA_RECEPTOR
    Compound_C["Compound C"] -->|"inhibits"| NMDA_RECEPTOR
    RAC1["RAC1"] -->|"regulates"| NMDA_RECEPTOR
    SYNAPSE["SYNAPSE"] -->|"regulates"| NMDA_RECEPTOR
    ARHGEF7 -->|"regulates"| NMDA_RECEPTOR
    P53["P53"] -->|"inhibits"| NMDA_RECEPTOR

Outgoing (45)

Target	Relation	Type	Str
Ischemic Stroke	contributes_to	disease	0.90
hippocampus	expressed_in	brain_region	0.90
synaptic plasticity	activates	pathway	0.90
neurons	expressed_in	cell_type	0.90
glutamate signaling	activates	pathway	0.90
cortex	expressed_in	brain_region	0.80
unfolded protein response	activates	pathway	0.80
astrocytes	expressed_in	cell_type	0.70
Alzheimer	associated_with	disease	0.60
Anxiety	inhibits	disease	0.60
Schizophrenia	inhibits	disease	0.60
neural stem cells	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
neuropeptide Y	binds	neurotransmitter	0.60
blood-brain barrier	expressed_in	brain_region	0.60
glycine	binds	neurotransmitter	0.60
thalamus	expressed_in	brain_region	0.60
hypothalamus	expressed_in	brain_region	0.60
B cells	expressed_in	cell_type	0.60
nucleus accumbens	expressed_in	brain_region	0.60
Multiple Sclerosis	activates	disease	0.60
Als	regulates	disease	0.60
Neuroinflammation	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Alzheimer	activates	disease	0.60
Alzheimer	inhibits	disease	0.60
Huntington	regulates	disease	0.60
Anxiety	activates	disease	0.60
Depression	regulates	disease	0.60
Aging	activates	disease	0.60
Als	inhibits	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Epilepsy	activates	disease	0.60
Als	activates	disease	0.60
pyroptosis	activates	pathway	0.60
GABAergic neurons	expressed_in	cell_type	0.60
Blood-Brain Barrier	activates	pathway	0.55
Pi3K/Akt	activates	pathway	0.55
Synaptic Plasticity	inhibits	pathway	0.55
Calcium Signaling	associated_with	pathway	0.55
Oxidative Stress	inhibits	pathway	0.55
Glycolysis	activates	pathway	0.55
GLUTAMATE	activates	concept	0.50
Synaptic Plasticity	regulates	pathway	0.50
GLUTAMATE	associated_with	concept	0.50

Incoming (130)

Source	Relation	Type	Str
Mk-801	inhibits	drug	0.95
GW201	modulates	compound	0.95
MTNR1B	associated_with	gene	0.90
MTNR1A	regulates	gene	0.90
MTNR1A	expressed_in	gene	0.90
MTNR1A	associated_with	gene	0.90
neurodegeneration	involves	disease	0.90
depression	involves	disease	0.90
Apoer2	activates	receptor	0.90
APOE	modulates	gene	0.90
RLN	activates	gene	0.85
Fibrillar Amyloid Beta	activates	compound	0.85
REELIN	activates	protein	0.85
schizophrenia	involves	disease	0.80
amyloid beta oligomers	inhibits	compound	0.80
memantine	inhibits	compound	0.80
MTNR1A	interacts_with	gene	0.80
MTNR1A	activates	gene	0.70
anxiety	involves	disease	0.70
MTNR1A	protects_against	gene	0.70
MTNR1A	treats	gene	0.70
APP	regulates	gene	0.70
stroke	involves	disease	0.70
epilepsy	involves	disease	0.70
APOE4	enhances	gene	0.70
GABA	expressed_in	gene	0.70
BDNF	activates	gene	0.70
NLRP3	activates	gene	0.70
BDNF	expressed_in	gene	0.70
Alzheimer's disease	involves	disease	0.70
ARHGEF7	regulates	gene	0.60
MAPK	upstream_of	gene	0.60
MAPK	regulates	gene	0.60
RAC1	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
diabetes	involves	disease	0.60
glioblastoma	involves	disease	0.60
DNA	expressed_in	gene	0.60
CACNA1C	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
TAU	associated_with	gene	0.60
KCNN3	associated_with	gene	0.60
CAV1	associated_with	gene	0.60
GFAP	inhibits	gene	0.60
AQP4	inhibits	gene	0.60
P53	inhibits	gene	0.60
ATP	inhibits	gene	0.60
TLR2	inhibits	gene	0.60
TLR4	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NMDA RECEPTOR in their description or question text

No additional research found