concept

KV1.3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KV1.3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

33Outgoing

16Incoming

0Experiments

0Debates

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💡 Concept Info

Name	KV1.3
Key Genes/Proteins	Alpha-Synuclein, ALZHEIMER, ALZHEIMER'S DISEASE, AND, CANCER, DEMENTIA
Related Diseases	Als, Alzheimer, Cancer, Dementia, Depression

Pathway Diagram

graph TD
    KV1_3["KV1.3"]
    KV1_3 -->|"modulates"| Neuroinflammation["Neuroinflammation"]
    KV1_3 -->|"modulates"| Neurodegeneration["Neurodegeneration"]
    KV1_3 -->|"expressed in"| Microglia["Microglia"]
    KV1_3 -->|"involved_in"| Parkinson_s_Disease["Parkinson's Disease"]
    KV1_3 -->|"contributes to"| Microglial_Activation["Microglial Activation"]
    KV1_3 -->|"activates"| neuroinflammation["neuroinflammation"]
    KV1_3 -->|"inhibits"| Melanoma["Melanoma"]
    KV1_3 -->|"inhibits"| Als["Als"]
    Alpha_Synuclein_Aggregates["Alpha-Synuclein Aggregates"] -->|"upregulates"| KV1_3
    FYN["FYN"] -->|"upregulates"| KV1_3
    SNCA["SNCA"] -->|"activates"| KV1_3
    PAP_1["PAP-1"] -->|"inhibits"| KV1_3
    AND["AND"] -->|"inhibits"| KV1_3
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| KV1_3

Outgoing (33)

Target	Relation	Type	Str
Neurodegeneration	modulates	process	0.95
Neuroinflammation	modulates	process	0.95
Parkinson's Disease	involved_in	disease	0.90
Microglia	expressed_in	cell_type	0.90
Parkinson'S Disease	involved_in	disease	0.90
Microglial Activation	contributes_to	process	0.85
Microglial Activation	modulates	process	0.85
Parkinson's disease	associated_with	disease	0.70
neuroinflammation	activates	process	0.70
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Dementia	activates	disease	0.65
Depression	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	activates	disease	0.65
Melanoma	inhibits	disease	0.65
P53	inhibits	gene	0.60
PARKINSON	activates	gene	0.60
AND	activates	gene	0.60
FYN	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
DEPRESSION	activates	gene	0.60
DEMENTIA	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
CANCER	inhibits	gene	0.60
STAT3	inhibits	gene	0.60

Incoming (16)

Source	Relation	Type	Str
Alpha-Synuclein	upregulates	protein	0.90
Alpha-Synuclein Aggregates	upregulates	compound	0.90
FYN	modulates	gene	0.85
FYN	upregulates	gene	0.85
FYN	phosphorylates	protein	0.80
FYN	regulates	gene	0.70
PAP-1	inhibits	drug	0.70
SNCA	activates	protein	0.70
ALZHEIMER	activates	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
FYN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KV1.3 in their description or question text

No additional research found