gene 725 words KG: FYN
Contents

FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase

🧬 Gene Info
Gene SymbolFYN
Full NameFYN Proto-Oncogene, Src Family Tyrosine Kinase
AliasesFyn Tyrosine Kinase
Chromosome6q21.
Protein TypeReceptor
Functionencodes a member of the Src family of non-receptor tyrosine kinases (SFKs).
Primary ExpressionT-cells, NK cells, and other immune cells
Molecular Weight60 kDa
Amino Acids537 aa
PathwaysAkt, Apoptosis, Dendritic Spine, Endocytosis, Pi3K
UniProt IDP39687
NCBI Gene ID2534
Ensembl IDENSG00000110881
OMIM137025
GeneCardsFYN
Human Protein AtlasFYN
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
InteractionsActin, AD, ADRB2, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections438 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (11)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (5)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: therapeutic_target
ADRB2 Gene
gene · KG edge: interacts_with
AKT1 Gene
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: causes

Knowledge Graph (12 edges)

FYN regulates NRF2
JUN regulates FYN
DAB1 associated_with FYN
DRD2 associated_with FYN
FYN associated_with CAMK2A
FYN associated_with SNCA
FYN associated_with SLC6A3
FYN associated_with UBC
FYN associated_with HOMER1
FYN associated_with COMT

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