protein

ABETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

0Hypotheses

0Analyses

50Outgoing

6Incoming

0Experiments

0Debates

No summary available yet.

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🔬 Protein Info

Gene Symbol	ABETA
Pathways	Protein Assembly
GeneCards	ABETA
Human Protein Atlas	ABETA
Associated Diseases	Alzheimer's Disease
Interactions	AMPAR, BDNF, CDK5, CREB, Fyn, GD3 synthase
KG Connections	74 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ruth E. Abeta

researcher · 634 words

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Pathway Diagram

graph TD
    ABETA["ABETA"] -->|"causes"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ABETA["ABETA"] -->|"involved in"| Protein_Assembly["Protein Assembly"]
    style Protein_Assembly fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ABETA["ABETA"] -->|"component of"| Extracellular_Deposits["Extracellular Deposits"]
    style Extracellular_Deposits fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ABETA["ABETA"] -->|"biomarker for"| Lewy_Pathology["Lewy Pathology"]
    style Lewy_Pathology fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ABETA["ABETA"] -->|"regulates"| CA2["CA2"]
    style CA2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ABETA["ABETA"] -->|"co discussed"| TAU["TAU"]
    style TAU fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ABETA["ABETA"] -->|"co discussed"| ALZHEIMER["ALZHEIMER"]
    style ALZHEIMER fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LEPTIN["LEPTIN"] -->|"regulates"| ABETA["ABETA"]
    style LEPTIN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GD3_synthase["GD3 synthase"] -->|"interacts"| ABETA["ABETA"]
    style GD3_synthase fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ABETA fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (73)

Target	Relation	Type	Str
Alzheimer's Disease	causes	disease	0.95
Alzheimer's Disease	biomarker_for	disease	0.90
Protein Assembly	involved_in	process	0.90
Extracellular Deposits	component_of	phenotype	0.90
APP	binds	protein	0.85
Lewy Pathology	biomarker_for	phenotype	0.85
GSK-3beta	activates	protein	0.80
CDK5	activates	protein	0.80
TLR4	activates	protein	0.80
TREM2	activates	protein	0.80
IL-1beta	upregulates	protein	0.80
TNF-alpha	upregulates	protein	0.80
C1q	upregulates	protein	0.80
RNS	induces	compound	0.80
NMDAR	activates	protein	0.80
TrkB	inhibits	protein	0.80
proBDNF	upregulates	protein	0.80
p75NTR	upregulates	protein	0.80
CREB	inhibits	protein	0.80
Tau Phosphorylation	contributes_to	process	0.80
synapse turnover	associated_with	process	0.80
BDNF	inhibits	protein	0.80
AMPAR	inhibits	protein	0.80
PrPC	binds_to	protein	0.80
mGluR5	binds_to	protein	0.80
Fyn	activates	protein	0.80
NR2B	activates	protein	0.80
CA2	regulates	protein	0.64
NEUROINFLAMMATION	co_discussed	entity	0.50
DENDRITIC SPINE	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
TFEB	co_discussed	entity	0.50
IL6	co_discussed	entity	0.50
AMYGDALA	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50
MACROPHAGES	co_discussed	entity	0.50
BECN1	co_discussed	entity	0.50
CERAMIDE	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
ALZHEIMER	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50
APP	co_discussed	entity	0.50
ASTROCYTE	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
APOPTOSIS	co_discussed	entity	0.50
CHOLESTEROL	co_discussed	entity	0.50
APOE	co_discussed	entity	0.50
LRP1	co_discussed	entity	0.50

Incoming (6)

Source	Relation	Type	Str
BACE1	upregulates	gene	0.92
GD3 synthase	interacts_with	gene	0.80
MTOR	inhibits_removal_of	gene	0.80
LEPTIN	regulates	protein	0.80
LEPTIN	inhibits	protein	0.70
ABCA1	co_discussed	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ABETA in their description or question text

No additional research found