gene

LCK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LCK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections

0Hypotheses

0Analyses

22Outgoing

45Incoming

0Experiments

0Debates

Summary

Page for LCK — LCK Proto-Oncogene, Src Family Tyrosine Kinase

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🧬 Gene Info

Gene Symbol	LCK
Full Name	LCK Proto-Oncogene, Src Family Tyrosine Kinase
Aliases	Lymphocyte-Specific Protein Tyrosine Kinase
Chromosome	1p35.2
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	T-lymphocytes and is essential for T-cell receptor (TCR) signaling, playing a critical role in adaptive immunity PMID: 15035502
Subcellular Localization	the cytoplasmic face of the plasma membrane. It is one of the earliest signaling molecules activated following TCR engag
Molecular Weight	56 kDa
Exons	12
Pathways	NF-κB
NCBI Gene ID	15035502
Ensembl ID	ENSG00000182866
GeneCards	LCK
Human Protein Atlas	LCK
Associated Diseases	Aging, Als, Alzheimer
Interactions	ACTB, APOPTOSIS, AUTOPHAGY, CAT, CCL5, CD19
KG Connections	67 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LCK["LCK"]
    Ms{"Ms"}
    LCK -->|"activates"| Ms
    Leukemia{"Leukemia"}
    LCK -->|"therapeutic target"| Leukemia
    Als{"Als"}
    LCK -->|"therapeutic target"| Als
    LCK -->|"therapeutic target"| Ms
    LCK -->|"regulates"| Ms
    Autism{"Autism"}
    LCK -->|"regulates"| Autism
    Parkinson{"Parkinson"}
    LCK -->|"activates"| Parkinson
    LCK -->|"expressed in"| Ms
    FYN["FYN"]
    LCK -->|"activates"| FYN
    SRC["SRC"]
    LCK -->|"activates"| SRC
    Mapk(["Mapk"])
    LCK -->|"interacts with"| Mapk
    Apoptosis(["Apoptosis"])
    LCK -->|"activates"| Apoptosis
    SRC -->|"activates"| LCK
    FYN -->|"activates"| LCK
    BCL2["BCL2"]
    BCL2 -->|"therapeutic target"| LCK
    CD4["CD4"]
    CD4 -->|"interacts with"| LCK
    MAPK3["MAPK3"]
    MAPK3 -->|"interacts with"| LCK
    ZAP70["ZAP70"]
    ZAP70 -->|"interacts with"| LCK
    TP53["TP53"]
    TP53 -->|"interacts with"| LCK
    MIRNAS["MIRNAS"]
    MIRNAS -->|"regulates"| LCK
    CD19["CD19"]
    CD19 -->|"interacts with"| LCK
    EEF2["EEF2"]
    EEF2 -->|"interacts with"| LCK
    CCL5["CCL5"]
    CCL5 -->|"interacts with"| LCK
    TNF["TNF"]
    TNF -->|"interacts with"| LCK
    style LCK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

Target	Relation	Type	Str
Parkinson	activates	disease	0.65
Ms	expressed_in	disease	0.65
Aging	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	activates	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Autism	regulates	disease	0.65
Mapk	interacts_with	pathway	0.60
FYN	activates	gene	0.60
SRC	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
T cells	expressed_in	cell_type	0.60
TCR	interacts_with	gene	0.60
RNA	associated_with	gene	0.60
Apoptosis	activates	pathway	0.60
Autophagy	activates	pathway	0.60
AND	associated_with	gene	0.60
TCR	activates	gene	0.60

Incoming (45)

Source	Relation	Type	Str
P62	associated_with	gene	0.70
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
TAU PATHOLOGY	associated_with	gene	0.60
AMYLOID-BETA	associated_with	gene	0.60
ALPHA-SYNUCLEIN	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
SRC	activates	gene	0.60
FYN	activates	gene	0.60
BCL2	therapeutic_target	gene	0.60
CD4	interacts_with	gene	0.60
MAPK3	interacts_with	gene	0.60
ZAP70	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
CD19	interacts_with	gene	0.60
EEF2	interacts_with	gene	0.60
CCL5	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
TLR7	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
RAC2	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
CDK4	interacts_with	gene	0.60
CDKN1A	interacts_with	gene	0.60
MFN1	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
MFN2	associated_with	gene	0.60
PTEN	activates	gene	0.60
PINK1	associated_with	gene	0.60
CDK1	inhibits	gene	0.60
CD19	inhibits	gene	0.60
STAT1	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TAU	associated_with	gene	0.60
FYN	interacts_with	entity	0.60
ALZHEIMER	associated_with	gene	0.60
MIRNAS	regulates	gene	0.60
LC3B	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
TCR	activates	gene	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LCK in their description or question text

No additional research found

LCK