gene

CUL3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CUL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

181Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CUL3 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, expressed in. Associated with ALS, Aging, Als. Connected to 151 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CUL3
Full Name	Cullin 3
Chromosome	2q36.2
Protein Type	Scaffold Protein
Function	encodes a scaffold protein that nucleates Cullin-RING E3 ubiquitin ligase complexes (CRL3s).
Primary Expression	Ubiquitous, enriched in brain and testis
Pathways	Akt, Apoptosis, Oxidative Stress, Pi3K, Proteasome
UniProt ID	Q13618
NCBI Gene ID	8452
Ensembl ID	ENSG00000036257
OMIM	603136
GeneCards	CUL3
Human Protein Atlas	CUL3
N-terminal domain	Binds BTB-domain substrate adaptors (e.g., KEAP1, KLHL20, SPOP, KCTD13)
C-terminal cullin homology domain	Binds RBX1 (RING-finger protein), which recruits E2 ubiquitin-conjugating enzymes
Associated Diseases	ALS
Interactions	AKT, AND, APOPTOSIS, AUTOPHAGY, BACH1, BCL2
KG Connections	181 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CUL3 — AlphaFold Q13618 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CUL3 — Cullin 3

gene · 766 words

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Pathway Diagram

graph TD
    CUL3["CUL3
Cullin 3 E3 Ligase"] -->|"regulates"| KEAP1["KEAP1"]
    CUL3 -->|"regulates"| NRF2["NRF2 Pathway"]
    CUL3 -->|"regulates"| Akt["AKT Signaling"]
    CUL3 -->|"activates"| BACH1["BACH1"]
    CUL3 -->|"regulates"| FYN["FYN Kinase"]
    CUL3 -->|"activates"| MTOR["mTOR Pathway"]
    CUL3 -->|"activates"| DEPDC5["DEPDC5"]
    CUL3 -->|"activates"| NPRL2["NPRL2"]

    CUL3 -->|"inhibits"| BECN1["BECN1/Autophagy"]
    CUL3 -->|"activates"| Apoptosis["Apoptosis"]

    AKT2["AKT"] -->|"activates"| CUL3
    BACH1 -->|"activates"| CUL3

    CUL3 -->|"regulates"| Cancer["Cancer"]
    CUL3 -->|"regulates"| ALS["ALS"]
    CUL3 -->|"associated with"| Methylation["DNA Methylation"]

    style CUL3 fill:#e74c3c,stroke:#c0392b,color:#e0e0e0
    style KEAP1 fill:#3498db,stroke:#2980b9,color:#e0e0e0
    style NRF2 fill:#3498db,stroke:#2980b9,color:#e0e0e0
    style MTOR fill:#2ecc71,stroke:#27ae60,color:#e0e0e0
    style Cancer fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0

Outgoing (119)

Target	Relation	Type	Str
DEPDC5	mediates	protein	0.90
NFE2L2	degrades	protein	0.90
DEPDC5	degrades	protein	0.85
Tumor	activates	disease	0.85
Cancer	activates	disease	0.85
Als	activates	disease	0.85
BECN1	inhibits	gene	0.80
TREM2	protects_against	gene	0.80
TREM2	upregulates	gene	0.80
CANCER	activates	gene	0.80
Als	regulates	disease	0.75
P62	interacts_with	gene	0.70
Mtor	activates	pathway	0.70
UBIQUITIN	interacts_with	gene	0.70
NRF2	interacts_with	gene	0.70
MTORC1	activates	gene	0.70
TREM2	expressed_in	gene	0.70
Autophagy	interacts_with	pathway	0.70
GENES	activates	gene	0.70
ALS	expressed_in	disease	0.65
Ms	activates	disease	0.65
Carcinoma	phosphorylates	disease	0.65
Ms	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Glioblastoma	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Aging	interacts_with	disease	0.65
Carcinoma	expressed_in	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Als	expressed_in	disease	0.65
Colorectal Cancer	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Cancer	inhibits	disease	0.65
ALS	activates	disease	0.65
Carcinoma	activates	disease	0.65
Ovarian Cancer	activates	disease	0.65
NRF2	regulates	protein	0.64
ALS	associated_with	disease	0.60
Mtor	phosphorylates	pathway	0.60
Innate Immunity	phosphorylates	pathway	0.60
NRF2	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BACH1	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60

Incoming (62)

Source	Relation	Type	Str
KEAP1	interacts_with	gene	0.99
SPOP	interacts_with	protein	0.95
UBIQUITIN	activates	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
ROS	inhibits	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
UBIQUITIN	regulates	gene	0.60
NRF2	interacts_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
CANCER	activates	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
MTOR	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
AKT	associated_with	gene	0.60
PI3K	activates	gene	0.60
NRF2	regulates	gene	0.60
BACH1	activates	gene	0.60
AKT	activates	gene	0.60
P38	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
KEAP1	regulates	gene	0.60
PKC	expressed_in	gene	0.60
AKT	regulates	gene	0.60
BACH1	regulates	gene	0.60
BCL2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
PI3K	associated_with	gene	0.60
BECN1	activates	gene	0.60
BECN1	regulates	gene	0.60
DNA	associated_with	gene	0.60
P53	associated_with	gene	0.60
GENES	activates	gene	0.60
ANTIOXIDANT GENES	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
C-JUN	expressed_in	gene	0.60
CYTOKINES	interacts_with	gene	0.60
LYSOSOME	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
CANCER	expressed_in	gene	0.60
NPRL2	activates	gene	0.60
VHL	expressed_in	gene	0.60
KEAP1	associated_with	gene	0.60
PKC	activates	gene	0.60
FYN	activates	gene	0.60
KEAP1	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
GPX4	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CUL3 in their description or question text

No additional research found