gene

BACH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BACH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

157Connections

0Hypotheses

0Analyses

50Outgoing

44Incoming

0Experiments

0Debates

Summary

BACH1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 114 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BACH1
Full Name	BTB Domain and CNC Homolog 1
Chromosome	21q21.3
Function	encodes a transcriptional repressor that competes with NRF2 for binding to antioxidant response elements (AREs) in the promoters of cytoprotective genes.
Primary Expression	Ubiquitous, high in brain, liver, spleen
Pathways	Akt, Apoptosis, Autophagy, Chaperone, Complement
UniProt ID	O14867
NCBI Gene ID	571
Ensembl ID	ENSG00000156273
OMIM	602751
GeneCards	BACH1
Human Protein Atlas	BACH1
Represses HMOX1	The HMOX1 promoter contains multiple AREs that are occupied by BACH1-Maf heterodimers in the absence of stress
Regulates iron metabolism	Controls ferritin heavy chain (FTH1) and ferroportin (SLC40A1) expression
Interactions	AKT, AND, ANTIOXIDANT GENES, APOPTOSIS, ASTROCYTE, CANCER
KG Connections	157 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BACH1 — AlphaFold O14867 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BACH1 — BTB Domain and CNC Homolog 1

gene · 835 words

→

BACH1 Protein — Transcriptional Repressor

protein · 1012 words

→

Pathway Diagram

graph TD
    BACH1["BACH1"]
    LDLR["LDLR"]
    BACH1 -->|"inhibits"| LDLR
    Cancer{"Cancer"}
    BACH1 -->|"activates"| Cancer
    Als{"Als"}
    BACH1 -->|"activates"| Als
    BACH1 -->|"regulates"| Cancer
    Aging{"Aging"}
    BACH1 -->|"activates"| Aging
    Neurodegeneration{"Neurodegeneration"}
    BACH1 -->|"activates"| Neurodegeneration
    Inflammation{"Inflammation"}
    BACH1 -->|"activates"| Inflammation
    BACH1 -->|"therapeutic target"| Als
    Tumor{"Tumor"}
    BACH1 -->|"inhibits"| Tumor
    Glioblastoma{"Glioblastoma"}
    BACH1 -->|"therapeutic target"| Glioblastoma
    ALS{"ALS"}
    BACH1 -->|"activates"| ALS
    Pi3K(["Pi3K"])
    BACH1 -->|"activates"| Pi3K
    PKC["PKC"]
    PKC -->|"activates"| BACH1
    FYN["FYN"]
    FYN -->|"activates"| BACH1
    KEAP1["KEAP1"]
    KEAP1 -->|"activates"| BACH1
    CUL3["CUL3"]
    CUL3 -->|"activates"| BACH1
    NRF2["NRF2"]
    NRF2 -->|"activates"| BACH1
    PI3K["PI3K"]
    PI3K -->|"activates"| BACH1
    GENES["GENES"]
    GENES -->|"activates"| BACH1
    AKT["AKT"]
    AKT -->|"regulates"| BACH1
    P62["P62"]
    P62 -->|"activates"| BACH1
    ANTIOXIDANT_GENES["ANTIOXIDANT GENES"]
    ANTIOXIDANT_GENES -->|"activates"| BACH1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"activates"| BACH1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"associated with"| BACH1
    style BACH1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (113)

Target	Relation	Type	Str
LDLR	inhibits	gene	0.85
SCF-type E3 ligases	regulated_by	protein complex	0.80
Oxidative Stress	activates	pathway	0.80
Inflammation	activates	disease	0.75
Als	therapeutic_target	disease	0.75
Oxidative Stress Response	regulates	process	0.75
Cancer	regulates	disease	0.75
OXIDATIVE STRESS	regulates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
Oxidative Stress	regulates	pathway	0.70
NRF2	regulates	protein	0.66
Aging	activates	disease	0.65
Tumor	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Ms	inhibits	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ischemia	expressed_in	disease	0.65
Als	degrades	disease	0.65
Als	regulates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
Cancer	activates	disease	0.65
Pi3K	regulates	pathway	0.60
Proteasome	regulates	pathway	0.60
Histone Modification	inhibits	pathway	0.60
Glycolysis	inhibits	pathway	0.60
APOPTOSIS	activates	gene	0.60
GENES	activates	gene	0.60
CANCER	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
PKC	activates	gene	0.60
AKT	activates	gene	0.60
CUL3	activates	gene	0.60
KEAP1	activates	gene	0.60
GBM	activates	gene	0.60
PI3K	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
STAT3	expressed_in	gene	0.60
HMOX1	activates	gene	0.60
IRF3	activates	gene	0.60
CGAS	activates	gene	0.60
STING	activates	gene	0.60
FSP1	inhibits	gene	0.60

Incoming (44)

Source	Relation	Type	Str
UBIQUITIN	regulates	gene	0.60
NRF2	degrades	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
AND	regulates	gene	0.60
GFP	regulates	gene	0.60
ASTROCYTE	inhibits	gene	0.60
AND	inhibits	gene	0.60
GSK3	activates	gene	0.60
PKC	activates	gene	0.60
FYN	activates	gene	0.60
KEAP1	activates	gene	0.60
CUL3	activates	gene	0.60
NRF2	activates	gene	0.60
PI3K	activates	gene	0.60
AKT	regulates	gene	0.60
P62	activates	gene	0.60
HK2	inhibits	gene	0.60
GAPDH	inhibits	gene	0.60
AKT	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
MAF	therapeutic_target	gene	0.60
TBK1	activates	gene	0.60
GPX4	inhibits	gene	0.60
FSP1	inhibits	gene	0.60
NCOR1	associated_with	gene	0.60
GENES	activates	gene	0.60
ANTIOXIDANT GENES	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MICROGLIA	associated_with	gene	0.60
JAK	inhibits	gene	0.60
MIRNAS	associated_with	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
FERROPTOSIS	regulates	gene	0.60
CANCER	regulates	gene	0.60
GBA	regulates	gene	0.60
ACTB	regulates	gene	0.60
GAPDH	regulates	gene	0.60
NRF2	regulates	gene	0.60
HMOX1	regulates	gene	0.60
ATG5	regulates	gene	0.60
UBIQUITIN	interacts_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BACH1 in their description or question text

No additional research found