protein

PKA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PKA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

114Connections

2Hypotheses

2Analyses

49Outgoing

50Incoming

0Experiments

2Debates

Summary

Page for PKA RIIβ Protein (Protein Kinase A Regulatory Subunit 2B)

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🔬 Protein Info

Gene Symbol	PKA
Aliases	Protein Kinase A Regulatory Subunit 2B
Function	Regulatory Subunit 2B)
Molecular Weight	45.5 kDa
Amino Acids	404 aa
Pathways	unfolded protein response, mitochondrial function, circadian regulation, insulin signaling, MAPK signaling
GeneCards	PKA
Human Protein Atlas	PKA
Associated Diseases	ALS, dementia
Known Drugs/Compounds	rapamycin
Interactions	ADRA2A, AKT, ALS, AMPK, ASC, ATXN1
KG Connections	114 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PKA["PKA"]
    CREB(["CREB"])
    PKA -->|"activates"| CREB
    JMJD3["JMJD3"]
    PKA -->|"phosphorylates"| JMJD3
    PAK4(["PAK4"])
    PKA -->|"degrades"| PAK4
    MERTK(["MERTK"])
    PKA -->|"activates"| MERTK
    NMDAR2B(["NMDAR2B"])
    NMDAR2B -->|"activates"| PKA
    FGF21(["FGF21"])
    FGF21 -->|"activates"| PKA
    S1P1["S1P1"]
    S1P1 -.->|"downregulates"| PKA
    NEURON(["NEURON"])
    NEURON -->|"activates"| PKA
    style PKA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (49)

Target	Relation	Type	Str
CREB	activates	protein	0.90
PAK4	degrades	protein	0.80
neurodegeneration	activates	disease	0.70
oxidative stress response	participates_in	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
neurons	expressed_in	cell_type	0.65
unfolded protein response	participates_in	pathway	0.65
JMJD3	activates	protein	0.64
dementia	associated_with	disease	0.60
epigenetic regulation	participates_in	pathway	0.60
autism spectrum disorder	interacts_with	disease	0.60
stem cells	expressed_in	cell_type	0.60
neuroinflammation	activates	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
ALS	associated_with	disease	0.60
RAMP1	activates	gene	0.60
PRKACB	associated_with	gene	0.60
CREB	phosphorylates	protein	0.60
apoptosis pathway	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
stroke	activates	disease	0.60
synaptic plasticity	participates_in	pathway	0.60
STAT3	activates	gene	0.60
PTEN	activates	gene	0.60
RIPK1	activates	gene	0.60
RNA	activates	gene	0.60
ROS	activates	gene	0.60
TLR	activates	gene	0.60
TNFAIP3	activates	gene	0.60
TRAF6	activates	gene	0.60
TRIM25	activates	gene	0.60
necroptosis	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
VDR	interacts_with	gene	0.60
macrophages	expressed_in	cell_type	0.55
astrocytes	expressed_in	cell_type	0.55
microglia	expressed_in	cell_type	0.55
circadian regulation	participates_in	pathway	0.55
insulin signaling	participates_in	pathway	0.55
MAPK signaling	participates_in	pathway	0.55
prion disease	activates	disease	0.55
TGF	activates	gene	0.55
TNF	activates	gene	0.55
TGF-beta signaling	participates_in	pathway	0.55
NF-kB signaling	participates_in	pathway	0.55
neurotrophin signaling	participates_in	pathway	0.55
mitochondrial function	participates_in	pathway	0.55
MERTK	activates	gene	0.50
SHP2	activates	protein	0.50

Incoming (65)

Source	Relation	Type	Str
NMDAR2B	activates	protein	0.90
cAMP	activates	molecule	0.90
FGF21	activates	protein	0.88
BACE1	regulates	gene	0.80
CREB	activates	gene	0.75
CREB	interacts_with	gene	0.60
ATXN1	activates	gene	0.60
ATXN1	associated_with	gene	0.60
LAMP2A	activates	gene	0.60
PERK	activates	gene	0.60
ASC	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
GSDMD	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
DRP1	protects_against	gene	0.60
AMPK	implicated_in	gene	0.60
ATXN1	phosphorylates	gene	0.60
ATXN1	regulates	gene	0.60
IRF8	activates	gene	0.60
LXR	activates	gene	0.60
MAPK	activates	gene	0.60
AMPK	activates	gene	0.60
PI3K	activates	gene	0.60
rapamycin	targets	drug	0.60
BACE1	inhibits	gene	0.60
AKT	activates	gene	0.60
BACE1	interacts_with	gene	0.60
PINK1	regulates	gene	0.60
CMKLR1	activates	gene	0.60
DRP1	regulates	gene	0.60
ERK1	regulates	gene	0.60
ALS	activates	gene	0.60
CREB	inhibits	gene	0.60
MTNR1A	activates	gene	0.60
CRH	activates	gene	0.60
HDAC3	activates	gene	0.60
EAAT2	activates	gene	0.60
GFAP	activates	gene	0.60
CREB1	activates	gene	0.60
FOXO1	activates	gene	0.60
ERK	associated_with	gene	0.60
GAP43	associated_with	gene	0.60
DRD2	activates	gene	0.55
BDNF	activates	gene	0.55
ADRA2A	activates	gene	0.55
CREB	regulates	gene	0.55
HCRTR2	activates	gene	0.55
GABRA1	activates	gene	0.55
IL-10	activates	gene	0.55
DARPP-32	activates	gene	0.55

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PGE2–EP2–cAMP–PKA Axis Displaces Pathological Microglial Mem	0.649	neuroinflammation	What specific astrocyte-derived factors
cAMP/PKA-Dependent Transcription Factor Activation via Nutri	0.420	neurodegeneration	Why do structurally diverse sugars (treh

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

neuroscience | 2026-04-11 | 0 hypotheses

How does ADCY8 mechanistically regulate long-term memory formation in migratory

memory and navigation | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular step

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The study identifies ADCY8 as associated with migratory distance differences and

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

Related Research

Hypotheses and analyses mentioning PKA in their description or question text

No additional research found

PKA