concept

CGAS-STING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CGAS-STING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

290Connections

2Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

4Debates

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💡 Concept Info

Name	CGAS-STING PATHWAY
Key Genes/Proteins	CGAS, CXCL10
Related Diseases	ALS, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, ASTROCYTE REACTIVITY

Pathway Diagram

graph TD
    CGAS_STING_PATHWAY["CGAS-STING PATHWAY"]
    style CGAS_STING_PATHWAY fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CGAS_STING_PATHWAY -->|"activates"| innate_immune_response["innate immune response"]
    CGAS_STING_PATHWAY -->|"involved_in"| Innate_Immunity["Innate Immunity"]
    CGAS_STING_PATHWAY -->|"promotes"| astrocyte_senescence["astrocyte senescence"]
    CGAS_STING_PATHWAY -->|"causes"| cardiac_inflammation(cardiac inflammation)
    CGAS_STING_PATHWAY -->|"causes"| ageing_related_inflammation(ageing-related inflammation)
    CGAS_STING_PATHWAY -->|"upregulates"| PRO_INFLAMMATORY_CYTOKINES([PRO-INFLAMMATORY CYTOKINES])
    CGAS_STING_PATHWAY -.->|"inhibits"| MTOR([MTOR])
    CGAS_STING_PATHWAY -->|"promotes"| neurodegeneration["neurodegeneration"]
    CGAS_STING_PATHWAY -->|"mediates"| Proinflammatory_Response["Proinflammatory Response"]
    CGAS_STING_PATHWAY -->|"activates"| Sterile_Inflammation["Sterile Inflammation"]
    Dna["Dna"] -->|"activates"| CGAS_STING_PATHWAY
    Mitophagy["Mitophagy"] -->|"interacts"| CGAS_STING_PATHWAY
    Substance_P([Substance P]) -.->|"inhibits"| CGAS_STING_PATHWAY
    Mitochondrial_DNA["Mitochondrial DNA"] -->|"activates"| CGAS_STING_PATHWAY
    substance_P([substance P]) -.->|"inhibits"| CGAS_STING_PATHWAY
    pathogenic_DNA([pathogenic DNA]) -->|"activates"| CGAS_STING_PATHWAY
    PINK1([PINK1]) -.->|"inhibits"| CGAS_STING_PATHWAY
    mitochondrial_DNA([mitochondrial DNA]) -->|"activates"| CGAS_STING_PATHWAY
    Damaged_Mitochondria(Damaged Mitochondria) -->|"activates"| CGAS_STING_PATHWAY
    Damaged_mitochondria["Damaged mitochondria"] -->|"activates"| CGAS_STING_PATHWAY

Outgoing (140)

Target	Relation	Type	Str
neurodegeneration	implicated_in	process	1.00
Neurodegeneration	promotes	process	0.95
Neuroinflammation	promotes	process	0.95
Amyotrophic Lateral Sclerosis	associated_with	disease	0.95
Innate Immunity	involved_in	process	0.95
innate immune response	activates	pathway	0.95
astrocyte senescence	promotes	process	0.92
neuroinflammation	regulates	process	0.90
Autophagy	activates	process	0.90
tumor-derived DNA	regulates	phenotype	0.90
Neuroinflammation	contributes_to	process	0.90
Neuroinflammation	mediates	process	0.90
neurodegeneration	promotes	process	0.90
Neurodegenerative Diseases	implicated_in	disease	0.90
Traumatic Brain Injury	involved_in	disease	0.90
PRO-INFLAMMATORY CYTOKINES	upregulates	protein	0.90
ageing-related inflammation	causes	phenotype	0.90
Mitochondrial DNA	associated_with	biomarker	0.90
Parkinson's Disease	contributes_to	disease	0.90
Neurodegeneration	contributes_to	process	0.90
Microglial Senescence	activates	phenotype	0.90
PD-L1	upregulates	protein	0.90
neuroinflammation	mediates	process	0.90
Proinflammatory Response	mediates	process	0.90
Pathogen Clearance	promotes	process	0.90
NLRP3 Inflammasome Activation	activates	process	0.90
Sterile Inflammation	activates	process	0.90
MTOR	inhibits	protein	0.90
cardiac inflammation	causes	phenotype	0.90
Inflammatory Cytokine Expression	upregulates	process	0.85
Abnormal Glial Activation	involved_in	process	0.85
Parkinson'S Disease	contributes_to	disease	0.85
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.85
Low-Grade Inflammation	activates	process	0.85
Aging	involved_in	phenotype	0.85
neuroinflammation	causes	phenotype	0.85
cellular senescence	promotes	process	0.85
systemic inflammation	promotes	phenotype	0.85
Ataxia-Telangiectasia	contributes_to	disease	0.85
PRO-INFLAMMATORY CYTOKINES	upregulates	protein	0.85
Neurodegenerative disorders	associated_with	disease	0.85
aging	associated_with	process	0.85
Cellular Senescence	involved_in	process	0.85
Inflammatory Cytokine Expression	upregulates	process	0.85
NLRP3 inflammasome activation	regulates	process	0.85
pulmonary fibrosis	promotes	disease	0.85
Ferroptosis	regulates	process	0.85
senescence	regulates	process	0.85
Proinflammatory Response	activates	process	0.85
innate immune activation	activates	process	0.85

Incoming (150)

Source	Relation	Type	Str
PGAM5	activates	protein	0.95
Cytosolic DNA buildup	activates	process	0.95
mtDNA efflux	activates	process	0.95
Dna	activates	compound	0.95
Mitophagy	interacts_with	process	0.95
Substance P	inhibits	protein	0.93
Mitochondrial DNA	activates	compound	0.92
PINK1	inhibits	gene	0.90
mitochondrial DNA	activates	protein	0.90
pathogenic DNA	activates	gene	0.90
substance P	inhibits	protein	0.90
Damaged mitochondria	activates	organelle	0.90
mitochondrial DNA release	activates	process	0.90
RU.521	inhibits	drug	0.90
Damaged Mitochondria	activates	phenotype	0.90
OMA1	activates	protein	0.90
Mitochondrial Dna	activates	biomarker	0.90
STING	associated_with	gene	0.90
41892314	links DNA damage to	paper	0.90
41892314	links	paper	0.90
TDP-43 pathology	associated_with	mechanism	0.90
41094684	senses	paper	0.90
41094684	plays a critical role in	paper	0.90
IL-6-STAT3 PATHWAY	regulates	pathway	0.88
STING	involved_in	protein	0.85
Disturbed intracellular trafficking	activates	process	0.85
Mitophagy	inhibits	process	0.85
H-151	inhibits	drug	0.85
Mitochondrial dysfunction	activates	mechanism	0.85
mtDNA	activates	biomarker	0.85
BCL-2-Mediated Apoptotic Machinery	activates	process	0.85
Protein Phase Separation	activates	mechanism	0.85
Mitochondrial DNA Release	activates	process	0.85
Nuclear Dna	activates	biomarker	0.85
α-Synuclein aggregation	activates	mechanism	0.80
Impaired DNA repair	activates	mechanism	0.80
Effective Mitophagy	inhibits	process	0.80
tumor-derived DNA	activates	gene	0.80
FGF21	inhibits	protein	0.80
Cellular Stress Response	activates	process	0.75
APOPTOSIS	triggers	process	0.70
DNA double-strand breaks	activates	process	0.70
TSG	inhibits	drug	0.70
damaged mitochondria	activates	cell_type	0.70
mitophagy	inhibits	process	0.70
APOE3S/S	inhibits	gene	0.70
microglia	expresses_in	cell_type	0.70
VPS13C	regulates	protein	0.70
BCL2	activates	protein	0.70
dysfunctional mitophagy	activates	process	0.70

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
cGAS-STING Pathway Hyperactivation Mediates Tau Propagation	0.760	neurodegeneration	Gap 006 analysis (archived stub)
cGAS Inhibitors for ALS Therapeutics: Targeting Upstream mtD	0.380	neuroinflammation	How does chronic cGAS/STING activation d

Mentioning Analyses (4)

Scientific analyses that reference this entity

Comparative epigenetic signatures: DNA methylation age acceleration and histone

neurodegeneration | 2026-04-18 | 7 hypotheses Top: 0.620

What is the optimal therapeutic window timing for autophagy enhancement versus s

molecular biology | 2026-04-07 | 8 hypotheses Top: 0.755

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 43 hypotheses Top: 0.893

Gap 006 analysis (archived stub)

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.760

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN [PMID:38712164]	Unknown		2025
The R136S mutation in the APOE3 gene confers resilience against tau pathology vi [PMID:40555238]	Unknown		2025
Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer [PMID:39753133]	Hyde VR, Zhou C, Fernandez JR, Chatterje	Cell reports	2025
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senes [PMID:39353433]	Carling GK, Fan L, Foxe NR, Norman K, Wo	Neuron	2024
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflam [PMID:34782623]	["Jin Meihua", "Shiwaku Hiroki", "Tanaka	Nature communications	2021

Debates (4)

Multi-agent debates referencing this entity

Analysis for knowledge gap 006 in the neurodegeneration domain.

closed · Rounds: 4 · Score: 0.79 · 2026-04-22

The sequential therapy hypothesis depends on identifying when autophagy failure

closed · Rounds: 4 · Score: 0.78 · 2026-04-21

Investigate shared DNA methylation age acceleration and histone modification pat

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning CGAS-STING PATHWAY in their description or question text

No additional research found