concept

EPIGENETIC REGULATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPIGENETIC REGULATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

438Connections

8Hypotheses

3Analyses

47Outgoing

50Incoming

15Experiments

3Debates

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💡 Concept Info

Name	EPIGENETIC REGULATION
Key Genes/Proteins	ABCA1, AKT, CHRNA7
Related Diseases	BREAST CANCER, CANCER, CHRONIC KIDNEY DISEASE, DEPRESSION, HUNTINGTON

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Epigenetic Regulation

mechanism · 2116 words

→

Pathway Diagram

graph TD
    EPIGENETIC_REGULATION["EPIGENETIC REGULATION"]
    EPIGENETIC_REGULATION -->|"regulates"| T_CELL_DIFFERENTIATION["T CELL DIFFERENTIATION"]
    EPIGENETIC_REGULATION -->|"involved_in"| Pancreatic_Ductal_Adenocarcino["Pancreatic Ductal Adenocarcinoma"]
    EPIGENETIC_REGULATION -->|"regulates"| senescence["senescence"]
    EPIGENETIC_REGULATION -->|"causes"| Senescence["Senescence"]
    EPIGENETIC_REGULATION -->|"regulates"| liver_brain_axis["liver-brain axis"]
    EPIGENETIC_REGULATION -->|"regulates"| INFLAMMATION["INFLAMMATION"]
    EPIGENETIC_REGULATION -->|"inhibits"| MTOR_SIGNALING["MTOR SIGNALING"]
    TET2["TET2"] -->|"mediates"| EPIGENETIC_REGULATION
    HDAC["HDAC"] -->|"mediates"| EPIGENETIC_REGULATION
    ASXL1["ASXL1"] -->|"involved_in"| EPIGENETIC_REGULATION
    lactylation["lactylation"] -->|"regulates"| EPIGENETIC_REGULATION
    PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"regulates"| EPIGENETIC_REGULATION
    BRD4["BRD4"] -->|"participates in"| EPIGENETIC_REGULATION
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| EPIGENETIC_REGULATION

Outgoing (47)

Target	Relation	Type	Str
tumorigenesis	contributes_to	process	0.90
neural stem cells	active_in	cell_type	0.90
T CELL DIFFERENTIATION	regulates	entity	0.90
Pancreatic Ductal Adenocarcinoma	involved_in	disease	0.85
senescence	regulates	process	0.82
Pancreatic Ductal Adenocarcinoma Development	contributes_to	process	0.80
Neuronal Vulnerability	modulates	phenotype	0.75
liver-brain axis	regulates	pathway	0.70
neurons	active_in	cell_type	0.70
cortex	active_in	brain_region	0.70
lipid metabolism	crosstalk_with	pathway	0.70
synaptic plasticity	crosstalk_with	pathway	0.60
thalamus	active_in	brain_region	0.60
hypothalamus	active_in	brain_region	0.60
unfolded protein response	crosstalk_with	pathway	0.60
pyroptosis	mediates	process	0.60
ferroptosis	crosstalk_with	pathway	0.60
hippocampus	active_in	brain_region	0.60
microglia	active_in	cell_type	0.60
astrocytes	active_in	cell_type	0.60
glutamate signaling	crosstalk_with	pathway	0.60
phagocytosis	mediates	process	0.60
INFLAMMATION	regulates	process	0.50
IMMUNE RESPONSE	co_discussed	process	0.40
MITOCHONDRIAL DYSFUNCTION	co_discussed	process	0.40
INFLAMMATION	co_discussed	process	0.40
NEUROINFLAMMATION	co_discussed	process	0.40
SENESCENCE	co_discussed	process	0.40
METASTASIS	co_discussed	process	0.40
MTOR	co_discussed	gene	0.40
SYNAPTIC PLASTICITY	co_discussed	process	0.40
NEURODEGENERATION	co_discussed	process	0.40
HUNTINGTON	co_discussed	disease	0.40
HUNTINGTON'S DISEASE	co_discussed	disease	0.40
RETINA	regulates	brain_region	0.35
MITOCHONDRIAL DYSFUNCTION	regulates	process	0.35
NEUROINFLAMMATION	regulates	process	0.35
SYNAPTIC PLASTICITY	regulates	process	0.35
NEURODEGENERATION	regulates	process	0.35
HUNTINGTON	regulates	disease	0.35
IMMUNE RESPONSE	regulates	process	0.35
TET2	regulates	gene	0.35
TGF-BETA	regulates	gene	0.35
METASTASIS	inhibits	process	0.35
MTOR SIGNALING	inhibits	process	0.35
MMP9	inhibits	gene	0.30
TP53	regulates	gene	0.30

Incoming (391)

Source	Relation	Type	Str
HDAC3	participates_in	gene	0.90
BDNF	participates_in	gene	0.90
Alzheimer's disease	involves	disease	0.90
DNA	participates_in	gene	0.90
TET2	mediates	protein	0.90
Sars-Cov-2	modulates	disease	0.85
TET2	involved_in	protein	0.85
neurons	active_in	cell_type	0.85
DAM microglia	active_in	cell_type	0.85
DNMT1	participates_in	gene	0.85
protein arginine methyltransferases	involved_in	protein	0.85
ASXL1	involved_in	gene	0.80
neurodegeneration	involves	disease	0.80
HDAC	participates_in	gene	0.80
frontotemporal dementia	involves	disease	0.80
HDAC4	participates_in	gene	0.80
HDAC9	participates_in	gene	0.80
PRMT1	involved_in	protein	0.80
HDAC2	participates_in	gene	0.80
HDAC1	participates_in	gene	0.80
AR	participates_in	gene	0.80
JAK	participates_in	gene	0.80
AMPK	participates_in	gene	0.80
BECN1	participates_in	gene	0.80
RNA	participates_in	gene	0.80
PIK3C3	participates_in	gene	0.80
HDAC6	participates_in	gene	0.80
microglia	active_in	cell_type	0.75
EZH2	participates_in	gene	0.75
SNCA	participates_in	gene	0.70
TGF	participates_in	gene	0.70
GBM	participates_in	gene	0.70
depression	involves	disease	0.70
BIN1	participates_in	gene	0.70
EP300	participates_in	gene	0.70
DNMT3A	participates_in	gene	0.70
ATG	participates_in	gene	0.70
NR3C1	participates_in	gene	0.70
TP53	participates_in	gene	0.70
UVRAG	participates_in	gene	0.70
GAPDH	participates_in	gene	0.70
MAP1LC3B	participates_in	gene	0.70
SQSTM1	participates_in	gene	0.70
aging	involves	disease	0.70
PI3K/AKT/mTOR	regulates	pathway	0.70
TFEB	participates_in	gene	0.70
CREB	participates_in	gene	0.70
MTOR	participates_in	gene	0.70
ULK1	participates_in	gene	0.70
SIRT1	participates_in	gene	0.70

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Chromatin Accessibility Restoration via BRD4 Modulation	0.768	neurodegeneration	Epigenetic reprogramming in aging neuron
Epigenetic Memory Erasure via TET2 Activation	0.741	neurodegeneration	Astrocyte reactivity subtypes in neurode
TET2-Mediated Demethylation Rejuvenation Therapy	0.706	neurodegeneration	Epigenetic clocks and biological aging i
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai	0.672	neurodegeneration	Epigenetic reprogramming in aging neuron
Temporal TET2-Mediated Hydroxymethylation Cycling	0.657	neurodegeneration	Epigenetic reprogramming in aging neuron

KDM6A-Mediated H3K27me3 Rejuvenation	0.653	neurodegeneration	Epigenetic clocks and biological aging i
DNMT1-Targeting Antisense Oligonucleotide Reset	0.648	neurodegeneration	Epigenetic clocks and biological aging i
HDAC2-Specific Repression of PU.1 Pioneer Factor Target Site	0.415	neurodegeneration	How does HDAC1/2 deletion specifically e

Mentioning Analyses (3)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.914

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.710

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741

Experiments (15)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Tet2 modulation in Aβ42-injured mouse hippocampal neurons	exploratory	Alzheimer's disease	0.900	0.00	primary mouse hippocampal neur	proposed	N/A
AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral study	validation	Alzheimer's disease	0.900	0.00	young APPswe/PSEN1 double-tran	proposed	N/A
Tet2 expression analysis in aged 2×Tg-AD mouse brains	exploratory	Alzheimer's disease	0.850	0.00	APPswe/PSEN1 double-transgenic	proposed	N/A
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
Epigenetic Dysregulation in Huntington's Disease — Therapeutic Targeti	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
Epigenetic Dysregulation Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Epigenetic Regulation Dysfunction in Alzheimer's and Parkinson's Disea	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,500,000
Proposed experiment from debate on Epigenetic clocks and biological ag	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$450,000
CRISPR Gene Correction Approaches for CBS/PSP	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
DNA Damage Repair Deficiency Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Mar	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develo	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Proposed experiment from debate on Microglia activate astrocytes via I	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
AAV-LRRK2 IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
AAV-LRRK2 Gene Therapy IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a sp [PMID:22729224]	["Rivi\u00e8re J", "Mirzaa G", "O'Roak B	Nature Genetics	2012	748
Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated [PMID:40929507]	Koh Y, Tengesdal IW, Jaiswal S	Annu Rev Pathol	2026	1
TET2 guards against unchecked BATF3-induced CAR T cell expansion. [PMID:36755094]	Jain N, Zhao Z, Feucht J, Koche R, Iyer	Nature	2023	1
Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Futur [PMID:36928826]	Singh I, Singh A	Curr Oncol Rep	2023	1
The function and regulation of TET2 in innate immunity and inflammation. [PMID:33085059]	Cong B, Zhang Q, Cao X	Protein Cell	2021	1
High-Resolution Differentiation of Enteric Bacteria in Premature Infant Fecal Mi [PMID:33593974]	Graf J, Ledala N, Caimano MJ, Jackson E,	mBio	2021	1
Development of a deep learning-based software for calculating cleansing score in [PMID:33627678]	Nam JH, Hwang Y, Oh DJ, Park J, Kim KB,	Sci Rep	2021	1
Bacterial siderophores in community and host interactions. [PMID:31748738]	Kramer J, Özkaya Ö, Kümmerli R	Nat Rev Microbiol	2020	1
Assessment of Out-of-Pocket Costs for Robotic Cancer Surgery in US Adults. [PMID:31940036]	Nabi J, Friedlander DF, Chen X, Cole AP,	JAMA Netw Open	2020	1
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans. [PMID:33398264]	Turner JS, Kim W, Kalaidina E, Goss CW,	Res Sq	2020	1
Multidisciplinary Approach to Interstitial Lung Diseases: Nothing Is Better than [PMID:32709146]	Vancheri C, Basile A	Diagnostics (Basel)	2020	1
Reply to Rosen: Temperature-growth relationship is robust. [PMID:31375623]	Diffenbaugh NS, Burke M	Proc Natl Acad Sci U S A	2019	1
Cryo-electron microscopy structures of human oligosaccharyltransferase complexes [PMID:31831667]	Ramírez AS, Kowal J, Locher KP	Science	2019	1
ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration [PMID:30683808]	Griffin EF, Scopel SE, Stephen CA, Holzh	Dis Model Mech	2019	1
Endodermal Maternal Transcription Factors Establish Super-Enhancers during Zygot [PMID:31167141]	Paraiso KD, Blitz IL, Coley M, Cheung J,	Cell Rep	2019	1
Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus. [PMID:29887377]	Quinodoz SA, Ollikainen N, Tabak B, Pall	Cell	2018	1
Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. [PMID:28319113]	Shen JP, Zhao D, Sasik R, Luebeck J, Bir	Nat Methods	2017	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with [PMID:28068668]	Britschgi A, Duss S, Kim S, Couto JP, Br	Nature	2017	1
Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cance [PMID:25219498]	Yoo HM, Kang SH, Kim JY, Lee JE, Seong M	Mol Cell	2014	1

Debates (3)

Multi-agent debates referencing this entity

Epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Astrocyte reactivity subtypes in neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Epigenetic clocks and biological aging in neurodegeneration

closed · Rounds: 4 · Score: 0.93 · 2026-04-06