gene

ASXL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ASXL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

104Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ASXL1
Full Name	Additional Sex Combs Like 1
Chromosome	20q11.21
Protein Type	Gene
Function	is a critical epigenetic regulator that encodes a chromatin-binding protein involved in histone modification and transcriptional regulation.
Primary Expression	Corpus Callosum
Amino Acids	561 aa
Exons	12
Pathways	Epigenetic, Immune Response, Innate Immunity, Stem Cell, inflammation
GeneCards	ASXL1
Human Protein Atlas	ASXL1
Associated Diseases	Als, Alzheimer, Cancer, Cardiovascular, Heart Failure, Inflammation
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, App, BRAF, CACNA1G
KG Connections	104 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ASXL1 - Additional Sex Combs Like 1

gene · 2276 words

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ASXL1 Protein

protein · 1191 words

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Pathway Diagram

graph TD
    ASXL1["ASXL1"] -->|"involved in"| Epigenetics["Epigenetics"]
    style Epigenetics fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ASXL1["ASXL1"] -->|"regulates"| Chronic_Inflammation["Chronic Inflammation"]
    style Chronic_Inflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ASXL1["ASXL1"] -->|"involved in"| Epigenetic_Regulation["Epigenetic Regulation"]
    style Epigenetic_Regulation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ASXL1["ASXL1"] -->|"contributes to"| Clonal_Hematopoiesis["Clonal Hematopoiesis"]
    style Clonal_Hematopoiesis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ASXL1["ASXL1"] -->|"modulates"| Inflammatory_Profile["Inflammatory Profile"]
    style Inflammatory_Profile fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ASXL1["ASXL1"] -->|"regulates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    style NEUROINFLAMMATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ASXL1["ASXL1"] -->|"therapeutic target"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    SF3B1["SF3B1"] -->|"activates"| ASXL1["ASXL1"]
    style SF3B1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TET2["TET2"] -->|"activates"| ASXL1["ASXL1"]
    style TET2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    U2AF1["U2AF1"] -->|"activates"| ASXL1["ASXL1"]
    style U2AF1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DNMT3A["DNMT3A"] -->|"activates"| ASXL1["ASXL1"]
    style DNMT3A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    GENES["GENES"] -->|"activates"| ASXL1["ASXL1"]
    style GENES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ASXL1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (81)

Target	Relation	Type	Str
Epigenetics	involved_in	process	0.90
Immune Response	regulates	process	0.85
Chronic Inflammation	regulates	process	0.85
Chronic Inflammation	promotes	process	0.80
Immune Responses	modifies	process	0.80
Epigenetic Regulation	involved_in	process	0.80
Clonal Hematopoiesis	contributes_to	biological_process	0.80
Inflammatory Profile	modulates	phenotype	0.78
inflammatory profiles	regulates	phenotype	0.78
NEUROINFLAMMATION	regulates	entity	0.75
BRAF	interacts_with	gene	0.75
Cardiovascular	causes	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Heart Failure	associated_with	disease	0.65
Osteoporosis	associated_with	disease	0.65
Ms	contributes_to	disease	0.65
Cardiovascular	contributes_to	disease	0.65
Atherosclerosis	activates	disease	0.65
Heart Failure	activates	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Cancer	causes	disease	0.65
Als	causes	disease	0.65
Inflammation	causes	disease	0.65
PPM1D	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
Stem Cell	therapeutic_target	cell_type	0.60
Epigenetic	activates	pathway	0.60
Immune Response	activates	pathway	0.60
Microglia	therapeutic_target	cell_type	0.60
Epigenetic	regulates	pathway	0.60
RNA	expressed_in	gene	0.60
U2AF1	activates	gene	0.60
DNMT3A	interacts_with	gene	0.60
SRSF2	interacts_with	gene	0.60
TET2	interacts_with	gene	0.60
DNMT3A	regulates	gene	0.60
JAK2	regulates	gene	0.60
TET2	regulates	gene	0.60
DNMT3A	biomarker_for	gene	0.60
TET2	biomarker_for	gene	0.60
DNMT3A	activates	gene	0.60

Incoming (23)

Source	Relation	Type	Str
TP53	activates	gene	0.60
DNMT3A	regulates	gene	0.60
TET2	regulates	gene	0.60
LDLR	associated_with	gene	0.60
COX6A2	activates	gene	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
AND	activates	gene	0.60
CACNA1G	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
INFLAMMATION	causes	gene	0.60
CANCER	causes	gene	0.60
GENES	causes	gene	0.60
SF3B1	activates	gene	0.60
TET2	activates	gene	0.60
U2AF1	activates	gene	0.60
DNMT3A	activates	gene	0.60
PPM1D	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity