gene

HDAC4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

181Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

HDAC4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, therapeutic target. Associated with ALS, Aging, Als. Connected to 50 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HDAC4
Full Name	Histone Deacetylase 4
Chromosome	2q37.3
Protein Family	Histone deacetylase, Class IIa
Function	Histone Modification: Removes acetyl groups from lysine tails of histones H3 and H4
Subcellular Localization	</strong></td><td>Nucleus/Cytoplasm (signal-dependent shuttling)</td></tr>
Molecular Weight	119 kDa
Amino Acids	1088 aa
Pathways	NF-κB, AMPK
UniProt ID	[P56524](https://www.uniprot.org/uniprot/P56524)
Ensembl ID	ENSG00000113048
OMIM	605314
GeneCards	HDAC4
Human Protein Atlas	HDAC4
MEF2-binding domain	HDAC4 represses MEF2 (Myocyte Enhancer Factor 2) transcription factors
Associated Diseases	Aging, ALS, Alzheimer, dementia, Soft Tissue Sarcoma, Tumor
Interactions	AGING, AMPK, AND, App, AQP1, CAMKII
KG Connections	181 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HDAC4["HDAC4"]
    Senescence{"Senescence"}
    HDAC4 -->|"therapeutic target"| Senescence
    Aging{"Aging"}
    HDAC4 -->|"inhibits"| Aging
    Ms{"Ms"}
    HDAC4 -->|"inhibits"| Ms
    Cardiovascular{"Cardiovascular"}
    HDAC4 -->|"therapeutic target"| Cardiovascular
    Tumor{"Tumor"}
    HDAC4 -->|"therapeutic target"| Tumor
    Als{"Als"}
    HDAC4 -->|"therapeutic target"| Als
    HDAC4 -->|"associated with"| Aging
    HDAC4 -->|"inhibits"| Senescence
    HDAC4 -->|"inhibits"| Cardiovascular
    HDAC4 -->|"associated with"| Tumor
    ALS{"ALS"}
    HDAC4 -->|"associated with"| ALS
    MEF2A["MEF2A"]
    HDAC4 -->|"inhibits"| MEF2A
    HDAC7["HDAC7"]
    HDAC7 -->|"associated with"| HDAC4
    PTEN["PTEN"]
    PTEN -->|"associated with"| HDAC4
    MEF2A -->|"inhibits"| HDAC4
    DNA["DNA"]
    DNA -->|"inhibits"| HDAC4
    PI3K["PI3K"]
    PI3K -->|"therapeutic target"| HDAC4
    GENES["GENES"]
    GENES -->|"therapeutic target"| HDAC4
    AMPK["AMPK"]
    AMPK -->|"associated with"| HDAC4
    AQP1["AQP1"]
    AQP1 -->|"inhibits"| HDAC4
    AKT["AKT"]
    AKT -->|"therapeutic target"| HDAC4
    PI3K -->|"associated with"| HDAC4
    AND["AND"]
    AND -->|"inhibits"| HDAC4
    AGING["AGING"]
    AGING -->|"inhibits"| HDAC4
    style HDAC4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (131)

Target	Relation	Type	Str
MEF2	interacts_with	protein	0.95
MEF2 TARGET GENES	downregulates	gene	0.95
Gene Repression	mediates	process	0.90
MEF2 Target Genes	downregulates	process	0.90
Transformation	causes	process	0.90
Soft Tissue Sarcoma	associated_with	disease	0.85
epigenetic regulation	participates_in	pathway	0.80
ALS	inhibits	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Senescence	therapeutic_target	disease	0.65
Aging	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Dementia	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiac	activates	disease	0.65
Fibrosis	activates	disease	0.65
Cardiovascular	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
Aging	regulates	disease	0.65
Als	inhibits	disease	0.65
Tumor	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
hippocampus	expressed_in	brain_region	0.60
AKT	therapeutic_target	gene	0.60
HDAC7	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
PTEN	associated_with	gene	0.60
HDAC3	expressed_in	gene	0.60
HDAC6	expressed_in	gene	0.60
TNF	activates	gene	0.60
MEF2A	regulates	entity	0.60
PTEN	regulates	entity	0.60
SYN1	regulates	gene	0.60
GRM3	regulates	gene	0.60
HDAC6	cleaves	gene	0.60
GENES	associated_with	gene	0.60
Endothelial	inhibits	cell_type	0.60
Pi3K/Akt	associated_with	pathway	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
Huntingtin	inhibits	protein	0.60
SIK3	activates	gene	0.60
synaptic plasticity	participates_in	pathway	0.60
dementia	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
MEF2A	inhibits	gene	0.60
AQP1	inhibits	gene	0.60
Angiogenesis	associated_with	pathway	0.60

Incoming (50)

Source	Relation	Type	Str
DNA	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
PI3K	associated_with	gene	0.60
HUNTINGTIN	inhibits	gene	0.60
AMPK	associated_with	gene	0.60
GENES	associated_with	gene	0.60
SIK3	regulates	gene	0.60
GSK3	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
AKT	therapeutic_target	gene	0.60
AKT	associated_with	gene	0.60
DNAJB6	inhibits	gene	0.60
CDK4	inhibits	gene	0.60
JNK	inhibits	gene	0.60
AGING	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
AND	inhibits	gene	0.60
AGING	regulates	gene	0.60
MEF2 TARGET GENES	associated_with	gene	0.60
AQP1	inhibits	gene	0.60
GRIA1	regulates	gene	0.60
REST	regulates	gene	0.60
CDK2	inhibits	gene	0.60
HDAC1	regulates	gene	0.60
HDAC3	regulates	gene	0.60
HDAC3	inhibits	gene	0.60
HDAC	associated_with	gene	0.60
HDAC7	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
MEF2A	inhibits	gene	0.60
PI3K	therapeutic_target	gene	0.60
CD4	activates	gene	0.60
CYTOKINES	activates	gene	0.60
AND	expressed_in	gene	0.60
GENES	therapeutic_target	gene	0.60
AQP1	regulates	entity	0.60
MEF2C	activates	gene	0.60
GRM3	regulates	gene	0.60
SYN1	regulates	gene	0.60
DNA	inhibits	gene	0.60
ALZHEIMER	regulates	gene	0.60
HDAC1	inhibits	gene	0.55
HDAC	inhibits	gene	0.55
DNAJB6	co_expressed_with	gene	0.50
GRIA1	co_expressed_with	gene	0.50
GRM3	co_expressed_with	gene	0.50
CDK4	co_expressed_with	gene	0.50
HDAC3	co_expressed_with	gene	0.50
HDAC1	co_expressed_with	protein	0.50
AQP1	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HDAC4 in their description or question text

No additional research found