protein

HDAC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

336Connections

4Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

HDAC1 is a protein involved in neurodegeneration research. Key relationships include: regulates, expressed in, activates. Associated with Aging, Alzheimer, Alzheimer's Disease. Connected to 111 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	HDAC1
Chromosome	1p35.2-p35.1<br>
Function	HDAC1 functions as a transcriptional repressor by deacetylating histone H3 and H4 tails, leading to chromatin compaction and reduced gene expression.
Primary Expression	the brain with high levels in: - Hippocampus (CA1-CA3 pyramidal neurons) - Cerebral cortex (lay
Molecular Weight	55 kDa
Pathways	NF-κB
UniProt ID	Q13547
NCBI Gene ID	3065
Ensembl ID	ENSG00000100994
GeneCards	HDAC1
Human Protein Atlas	HDAC1
Chromatin Compaction	Deacetylates histones to promote heterochromatin formation
Transcriptional Repression	Part of Sin3A, CoREST, and NuRD complexes
Cell Cycle Regulation	Controls expression of cell cycle regulators
DNA Damage Response	Regulates DNA repair gene expression
Associated Diseases	Alzheimer, disease, synaptic dysfunction
Known Drugs/Compounds	BORTEZOMIB
Interactions	AKT, AND, APOPTOSIS, App, AUTOPHAGY, BCL-2
SciDEX Hypotheses	Microglial Priming Window for HDAC1-Dependent DAM
KG Connections	336 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HDAC1 — AlphaFold Q13547 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HDAC1["HDAC1"]
    p65["p65"]
    HDAC1 -->|"modifies"| p65
    Neurodegeneration{"Neurodegeneration"}
    HDAC1 -->|"contributes to"| Neurodegeneration
    Parkinson{"Parkinson"}
    HDAC1 -->|"regulates"| Parkinson
    Alzheimer{"Alzheimer"}
    HDAC1 -->|"regulates"| Alzheimer
    Neuroinflammation{"Neuroinflammation"}
    HDAC1 -->|"regulates"| Neuroinflammation
    Inflammation{"Inflammation"}
    HDAC1 -->|"regulates"| Inflammation
    Huntington{"Huntington"}
    HDAC1 -->|"regulates"| Huntington
    Ms{"Ms"}
    HDAC1 -->|"regulates"| Ms
    HDAC2["HDAC2"]
    HDAC1 -->|"associated with"| HDAC2
    HDAC3["HDAC3"]
    HDAC1 -->|"associated with"| HDAC3
    NEURODEGENERATION["NEURODEGENERATION"]
    HDAC1 -->|"associated with"| NEURODEGENERATION
    HDAC1 -->|"expressed in"| Ms
    GATA4["GATA4"]
    GATA4 -->|"interacts with"| HDAC1
    SIRT6["SIRT6"]
    SIRT6 -->|"regulates"| HDAC1
    HDAC11["HDAC11"]
    HDAC11 -->|"expressed in"| HDAC1
    HDAC2 -->|"expressed in"| HDAC1
    SIRT7["SIRT7"]
    SIRT7 -->|"regulates"| HDAC1
    SIRT5["SIRT5"]
    SIRT5 -->|"regulates"| HDAC1
    BDNF["BDNF"]
    BDNF -->|"regulates"| HDAC1
    SIRT1["SIRT1"]
    SIRT1 -->|"regulates"| HDAC1
    HDAC3 -->|"expressed in"| HDAC1
    HDAC7["HDAC7"]
    HDAC7 -->|"expressed in"| HDAC1
    SIRT4["SIRT4"]
    SIRT4 -->|"regulates"| HDAC1
    HDAC6["HDAC6"]
    HDAC6 -->|"expressed in"| HDAC1
    style HDAC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (202)

Target	Relation	Type	Str
p65	modifies	protein	0.90
synaptic dysfunction	causes	phenotype	0.80
epigenetic regulation	participates_in	pathway	0.80
Tumor	activates	disease	0.75
Cancer	expressed_in	disease	0.75
NEURONS	activates	cell_type	0.70
Ms	regulates	disease	0.65
BORTEZOMIB	activates	drug	0.65
Huntington	regulates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Aging	regulates	disease	0.65
Cancer	activates	disease	0.65
Breast Cancer	activates	disease	0.65
NEURODEGENERATION	associated_with	concept	0.65
Schizophrenia	expressed_in	disease	0.65
neurons	expressed_in	cell_type	0.65
Inflammation	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	activates	disease	0.65
Gastric Cancer	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Autoimmune	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
HDAC3	associated_with	gene	0.65
HDAC2	associated_with	gene	0.65
Carcinoma	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
Breast Cancer	regulates	disease	0.65
Diabetes	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Depression	activates	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Parkinson	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
PI3K	targets	gene	0.60
HDAC8	inhibits	gene	0.60
MAPK8	targets	gene	0.60
SIRT2	inhibits	gene	0.60
HDAC4	regulates	gene	0.60
CANCER	activates	gene	0.60
HDAC6	implicated_in	gene	0.60
HDAC9	regulates	gene	0.60
NMDAR	activates	gene	0.60
Apoptosis	regulates	pathway	0.60

Incoming (134)

Source	Relation	Type	Str
h-e5f1182b	targets	hypothesis	0.90
GATA4	interacts_with	protein	0.90
GDNF	inhibits	gene	0.70
TET2	inhibits	gene	0.70
HDAC	inhibits	gene	0.65
APP	regulates	gene	0.65
HDAC3	expressed_in	gene	0.60
HDAC7	expressed_in	gene	0.60
SIRT4	regulates	gene	0.60
HDAC6	expressed_in	gene	0.60
SIRT2	regulates	gene	0.60
TAZ	activates	gene	0.60
HDAC10	activates	gene	0.60
NF-ΚB	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
AND	inhibits	gene	0.60
BCL-2	inhibits	gene	0.60
ALZHEIMER	associated_with	gene	0.60
HDAC8	therapeutic_target	gene	0.60
HDAC6	therapeutic_target	gene	0.60
HDAC2	therapeutic_target	gene	0.60
HDAC3	therapeutic_target	gene	0.60
CBP	regulates	gene	0.60
APP	targets	gene	0.60
CXCL8	targets	gene	0.60
AKT	targets	gene	0.60
AKT1	targets	gene	0.60
EGFR	targets	gene	0.60
EP300	targets	gene	0.60
NEURODEGENERATION	contributes_to	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
HUNTINGTON	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
RNA	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
AND	interacts_with	gene	0.60
NF-ΚB	interacts_with	gene	0.60
WNT	regulates	gene	0.60
DNA	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
SIRT6	regulates	gene	0.60
HDAC11	expressed_in	gene	0.60
HDAC2	expressed_in	gene	0.60
SIRT7	regulates	gene	0.60
SIRT5	regulates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC1/2 Complex Restoration Corrects Age-Related Histone Hyp	0.520	neurodegeneration	Investigate mechanisms of epigenetic rep
Microglial Priming Window for HDAC1-Dependent DAM Transition	0.463	neurodegeneration	What is the optimal therapeutic window d
MITF Acts as the Primary Transcriptional Effector Downstream	0.444	neurodegeneration	How does HDAC1/2 deletion specifically e
LncRNA-HDAC1 Complex Formation Locks Microglia in Primed Sta	0.420	developmental neurobiology	Do perinatal immune challenges create pe

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.651

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning HDAC1 in their description or question text

No additional research found

HDAC1

Understanding Entity Pages

Summary

Wiki Pages (6)

HDAC1 Gene

HDAC10 Gene

HDAC11 Gene

HDAC11 Protein

HDAC1 Protein

HDAC10 Protein