gene

EZH2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EZH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

292Connections

3Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

5Debates

Summary

EZH2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, therapeutic target. Associated with ALS, Als, Bipolar. Connected to 166 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	EZH2
Full Name	Enhancer of Zeste Homolog 2
Chromosome	7q36.1
Function	H3K27me3 is the transcriptionally repressive mark that defines Polycomb-silenced chromatin.
Molecular Weight	85.4 kDa
Amino Acids	746 aa
Exons	20
Pathways	Autophagy, Circadian Rhythm, Epigenetic, Histone Modification, Inflammasome
UniProt ID	Q15910
NCBI Gene ID	2146
Ensembl ID	ENSG00000106462
OMIM	601573
GeneCards	EZH2
Human Protein Atlas	EZH2
Monomethylation (H3K27me1)	Often associated with gene activation
Associated Diseases	Cancer, Infection, Inflammation, major depressive disorder, neurodegeneration, Prostate Cancer
Known Drugs/Compounds	EPZ6438
Interactions	AGING, AKT, AMPK, AND, App, ATG16L1
SciDEX Hypotheses	EZH2 Inhibitor Therapy to Restore Neuronal Identit
KG Connections	292 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EZH2 — AlphaFold Q15910 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

EZH2 — Enhancer of Zeste Homolog 2

gene · 1311 words

→

EZH2 Protein

protein · 621 words

→

Pathway Diagram

graph TD
    EZH2["EZH2"]
    EZH2 -->|"regulates"| TIMP1["TIMP1"]
    EZH2 -->|"regulates"| H3K27me3["H3K27me3"]
    EZH2 -->|"activates"| Als["Als"]
    EZH2 -->|"activates"| Ms["Ms"]
    EZH2 -->|"activates"| Inflammation["Inflammation"]
    EZH2 -.biomarker for.-> Cancer["Cancer"]
    EZH2 -.biomarker for.-> Tumor["Tumor"]
    EZH2 -->|"target for"| Carcinoma["Carcinoma"]
    EPZ6438["EPZ6438"] -->|"inhibits"| EZH2
    STING["STING"] -->|"activates"| EZH2
    GENES["GENES"] -->|"activates"| EZH2
    DNA["DNA"] -->|"activates"| EZH2
    IRF3["IRF3"] -->|"activates"| EZH2
    SOX2["SOX2"] -.biomarker for.-> EZH2
    ATM["ATM"] -.biomarker for.-> EZH2
    GAIN["GAIN"] -.biomarker for.-> EZH2
    BCL_2["BCL-2"] -.biomarker for.-> EZH2

Outgoing (189)

Target	Relation	Type	Str
H3K27me3	deposits	biomarker	0.90
MMP10	regulates	gene	0.90
H3K27me3	catalyzes	mechanism	0.88
Als	regulates	disease	0.85
Cancer	regulates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Diabetes	activates	disease	0.75
epigenetic regulation	participates_in	pathway	0.75
AKT	regulates	gene	0.70
CANCER	regulates	gene	0.70
H3K27me3	regulates	process	0.70
TH	inhibits	gene	0.70
major depressive disorder	associated_with	disease	0.70
TIMP1	regulates	protein	0.70
synaptic transmission	inhibits	phenotype	0.70
Epigenetic	inhibits	pathway	0.70
Ms	inhibits	disease	0.65
Als	activates	disease	0.65
Cancer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Epilepsy	regulates	disease	0.65
Tumor	biomarker_for	disease	0.65
Fibrosis	activates	disease	0.65
Cardiac	activates	disease	0.65
Ms	biomarker_for	disease	0.65
Prostate Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Bipolar	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Glioblastoma	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
ALS	activates	disease	0.65
Tumor	regulates	disease	0.65
Depression	activates	disease	0.65
Senescence	activates	disease	0.65
MICROGLIA	inhibits	cell_type	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
Ms	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	associated_with	disease	0.65
unfolded protein response	participates_in	pathway	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65

Incoming (103)

Source	Relation	Type	Str
PCGF1	upregulates	gene	0.90
EPZ6438	inhibits	drug	0.70
DNMT1	regulates	gene	0.70
AKT	inhibits	gene	0.70
PI3K	regulates	gene	0.70
TBK1	interacts_with	gene	0.65
ROS	activates	gene	0.60
MEK	activates	gene	0.60
SYNAPSE	regulates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
PCGF1	activates	gene	0.60
DEPRESSION	activates	gene	0.60
NF-ΚB	activates	gene	0.60
MAPK	activates	gene	0.60
STING	activates	gene	0.60
IRF3	activates	gene	0.60
FGFR1	therapeutic_target	gene	0.60
SOX2	therapeutic_target	gene	0.60
CDK4	therapeutic_target	gene	0.60
RB1	therapeutic_target	gene	0.60
CDKN2A	therapeutic_target	gene	0.60
PI3K	associated_with	gene	0.60
AKT	associated_with	gene	0.60
CXCL8	regulates	gene	0.60
TP53	regulates	gene	0.60
SRC	regulates	gene	0.60
HDAC1	interacts_with	gene	0.60
SMAD2	regulates	gene	0.60
SP1	regulates	gene	0.60
BMP2	regulates	gene	0.60
AGING	activates	gene	0.60
CANCER	inhibits	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
AND	interacts_with	gene	0.60
BRD4	activates	gene	0.60
DNA	biomarker_for	gene	0.60
BCL-2	biomarker_for	gene	0.60
ATM	biomarker_for	gene	0.60
GAIN	biomarker_for	gene	0.60
OVERVIEW	biomarker_for	gene	0.60
BRCA1	biomarker_for	gene	0.60
MICROGLIA	activates	gene	0.60
SOX2	biomarker_for	gene	0.60
SMO	therapeutic_target	gene	0.60
HDAC6	interacts_with	gene	0.60
CANCER	activates	gene	0.60
AMPK	expressed_in	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
MIRNAS	regulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
EZH2-Mediated H3K27me3 Spreading in Senescent ALS Microglia	0.693	ALS	What are the mechanisms by which microgl
Pharmacological EZH2 Inhibition Resets Polycomb-Mediated Rep	0.680	neurodegeneration	epigenetic reprogramming aging neurons
EZH2 Inhibitor Therapy to Restore Neuronal Identity Genes	0.320	neurodegeneration	Comparative epigenetic signatures across

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (5)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning EZH2 in their description or question text

No additional research found