biological_process

METASTASIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about METASTASIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

828Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🧬 Biological Process Info

Name	METASTASIS
Key Genes/Proteins	AKT, CASP3, CHRNA7, COMPLEMENT, DRP1
Related Diseases	BREAST CANCER, CANCER, CARCINOMA, COLORECTAL CANCER

Pathway Diagram

graph TD
    METASTASIS["METASTASIS"] -->|"activates"| CANCER["CANCER"]
    style CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    METASTASIS["METASTASIS"] -->|"activates"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    style HEPATOCELLULAR_CARCINOMA fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    METASTASIS["METASTASIS"] -->|"activates"| STAT3["STAT3"]
    style STAT3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    METASTASIS["METASTASIS"] -->|"regulates"| BREAST_CANCER["BREAST CANCER"]
    style BREAST_CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    METASTASIS["METASTASIS"] -->|"activates"| MTOR["MTOR"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    METASTASIS["METASTASIS"] -->|"activates"| AKT["AKT"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    METASTASIS["METASTASIS"] -->|"activates"| CARCINOMA["CARCINOMA"]
    style CARCINOMA fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    EMT["EMT"] -->|"activates"| METASTASIS["METASTASIS"]
    style EMT fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    PGC1A["PGC1A"] -->|"activates"| METASTASIS["METASTASIS"]
    style PGC1A fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    TRF33["TRF33"] -.->|"inhibits"| METASTASIS["METASTASIS"]
    style TRF33 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    HEPATOCELLULAR_CARCINOMA_1["HEPATOCELLULAR CARCINOMA"] -->|"associated"| METASTASIS["METASTASIS"]
    style HEPATOCELLULAR_CARCINOMA_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    EXOSOMES["EXOSOMES"] -->|"causes"| METASTASIS["METASTASIS"]
    style EXOSOMES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style METASTASIS fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (84)

Target	Relation	Type	Str
CANCER	activates	disease	0.86
CANCER	associated_with	disease	0.72
CANCER	inhibits	disease	0.72
HDAC3	regulates	gene	0.65
MMP9	regulates	gene	0.65
PI3K/AKT PATHWAY	activates	pathway	0.65
PI3K/AKT PATHWAY	interacts_with	pathway	0.65
PI3K/AKT PATHWAY	regulates	pathway	0.65
PI3K	interacts_with	gene	0.65
EXOSOME	activates	organelle	0.65
AKT	mediated_by	gene	0.65
CANCER	regulates	disease	0.58
DRUG RESISTANCE	implicated_in	phenotype	0.55
GLIOMA	expressed_in	disease	0.55
EXOSOME	associated_with	organelle	0.45
LUTEOLIN	associated_with	drug	0.45
ASPIRIN	associated_with	drug	0.45
STAT3	activates	gene	0.44
BREAST CANCER	regulates	disease	0.44
MTOR	activates	gene	0.44
AKT	activates	gene	0.44
CANCER	causes	disease	0.44
HEPATOCELLULAR CARCINOMA	activates	disease	0.44
HEPATOCELLULAR CARCINOMA	inhibits	disease	0.44
OXIDATIVE STRESS	co_discussed	process	0.40
VEGF	co_discussed	gene	0.40
PI3K	co_discussed	gene	0.40
MTOR	co_discussed	gene	0.40
UBIQUITIN	co_discussed	protein	0.40
NEUROGENESIS	co_discussed	process	0.40
OBESITY	co_discussed	disease	0.40
NECROPTOSIS	co_discussed	process	0.40
MICRORNA REGULATION	activates	process	0.35
MTOR SIGNALING	inhibits	process	0.35
NECROPTOSIS	regulates	process	0.35
NEUROGENESIS	activates	process	0.35
PI3K/AKT SIGNALING	regulates	process	0.35
VEGF	implicated_in	gene	0.35
PI3K/AKT SIGNALING	inhibits	process	0.35
NAFLD	metabolizes	disease	0.35
NAFLD	activates	disease	0.35
NAFLD	expressed_in	disease	0.35
MICRORNA REGULATION	regulates	process	0.35
SLC7A11	implicated_in	gene	0.35
ORGANOIDS	expressed_in	cell_type	0.35
MTOR SIGNALING	activates	process	0.35
OBESITY	activates	disease	0.35
SLC7A11	inhibits	gene	0.35
CANCER	implicated_in	disease	0.30
TGF-BETA	associated_with	gene	0.30

Incoming (744)

Source	Relation	Type	Str
APOPTOSIS	inhibits	gene	1.00
GENES	therapeutic_target	gene	1.00
AKT	activates	gene	1.00
Tumor	associated_with	disease	1.00
AKT	therapeutic_target	gene	1.00
PI3K	activates	gene	1.00
Breast Cancer	therapeutic_target	disease	1.00
MITOPHAGY	activates	gene	1.00
STAT3	therapeutic_target	gene	1.00
STAT3	inhibits	gene	1.00
MTOR	activates	gene	1.00
AUTOPHAGY	therapeutic_target	gene	1.00
CANCER	causes	gene	1.00
Als	inhibits	disease	1.00
CANCER	contributes_to	gene	1.00
Lung Cancer	activates	disease	1.00
Cancer	contributes_to	disease	1.00
Tumor	contributes_to	disease	1.00
Cancer	causes	disease	1.00
CYTOKINES	therapeutic_target	gene	1.00
Als	treats	disease	1.00
ERK	inhibits	gene	1.00
Breast Cancer	activates	disease	1.00
Colorectal Cancer	activates	disease	1.00
OVERVIEW	therapeutic_target	gene	1.00
MTOR	therapeutic_target	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
Tumor	causes	disease	1.00
INFLAMMATION	activates	gene	1.00
MICRORNAS	therapeutic_target	gene	1.00
Lung Cancer	therapeutic_target	disease	1.00
CANCER	associated_with	gene	1.00
Tumor	implicated_in	disease	1.00
Cancer	associated_with	disease	1.00
PI3K	therapeutic_target	gene	1.00
Inflammation	activates	disease	1.00
Cancer	inhibits	disease	1.00
Tumor	inhibits	disease	1.00
CANCER	therapeutic_target	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	regulates	disease	1.00
Carcinoma	associated_with	disease	1.00
APOPTOSIS	regulates	gene	1.00
NF-ΚB	activates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Breast Cancer	treats	disease	1.00
CANCER	regulates	gene	1.00
Cancer	activates	disease	1.00
Als	implicated_in	disease	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity