Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Neuronal Vulnerability: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Reduced STMN2 | contributes_to | biomarker | 0.85 |
| Endoplasmic Reticulum Stress | contributes_to | process | 0.85 |
| TDP43 | mediates | protein | 0.85 |
| Er Stress | contributes_to | process | 0.80 |
| Epigenetic Regulation | modulates | process | 0.75 |
| Tau Clearance | protects_against | process | 0.75 |
| mitophagy impairment | causes | mechanism | 0.70 |
| sleep disturbances | risk_factor_for | phenotype | 0.70 |
| Metabolic coupling failure | causes | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Selective Neuronal Vulnerability Network Targeting | 0.638 | neurodegeneration | Gene expression changes in aging mouse b |
| Mitochondrial Dysfunction Increasing Neuronal Vulnerability | 0.470 | neurodegeneration | How does APOE4 mechanistically increase |
| Astrocytic APOE4 Disruption of GABAergic Support Increasing | 0.450 | neurodegeneration | How does APOE4 mechanistically increase |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.629
neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.760
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Multiomics Profiling of T-cell Leukemia and Lymphoma Enables Targeted Therapeuti [PMID:41166698] | Ianevski A, Nader K, Nguyen J, Sorger H, | Cancer Res | 2026 | 0 |
| Outer retinal tubulation associated with photoreceptor degeneration. [PMID:41548710] | Lin V, Lee W, Kang EY, Liu PK, Wang NK | Prog Retin Eye Res | 2026 | 0 |
| Therapeutic targeting of cancer stem cell-specific surface glycans and glycoprot [PMID:41667793] | Al-Khreisat MJ, Abdulsahib WK, Jasim IK, | Discov Oncol | 2026 | 0 |
| Modest neurodevelopment impacts of APOE4 in a human brain organoid model of low- [PMID:41697903] | Muniz-Perez A, Meyer-Acosta KK, Boyana S | Dev Neurosci | 2026 | 0 |
| Dual roles of basal NLRP3 expression in cognitive and neurogenic aging. [PMID:41779054] | Komleva YK, Khilazheva ED, Mosiagina AI, | Biogerontology | 2026 | 0 |
| Breast tumour-secreted ADAM10 mediates atrial fibrogenesis and fibrillation. [PMID:41780910] | Xue G, Zhang P, Zhan G, Wang X, Dong H e | Eur Heart J | 2026 | 0 |
| Immunohistochemical Markers of Mitochondrial Electron Transport Chain Instabilit [PMID:41898675] | Baranich TI, Sukhorukov VS, Velts OV, Vo | Int J Mol Sci | 2026 | 0 |
| Cell line-specific modulation of inflammation by oestradiol in an in vitro model [PMID:41360307] | Kirkpatrick M, Alboni S, Imbeni F, Maria | Brain, behavior, and immunity | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.79 · 2026-04-22
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.95 · 2026-04-01
Hypotheses and analyses mentioning Neuronal Vulnerability in their description or question text
No additional research found