gene

HDAC9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

2Analyses

24Outgoing

14Incoming

0Experiments

2Debates

Summary

Histone Deacetylase 9 - class IIa HDAC involved in epigenetic regulation, synaptic plasticity, and neurodegeneration

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🧬 Gene Info

Gene Symbol	HDAC9
Full Name	Histone Deacetylase 9
Chromosome	7p21.1
Function	encodes a class IIa histone deacetylase that plays crucial roles in epigenetic regulation, transcriptional control, and cellular signaling in the brain.
Primary Expression	Brain, heart, skeletal muscle
Molecular Weight	110 kDa
UniProt ID	Q9UKV0
NCBI Gene ID	9734
Ensembl ID	ENSG00000048828
OMIM	606365
GeneCards	HDAC9
Human Protein Atlas	HDAC9
Associated Diseases	Als, Coronary Artery Disease, Inflammation, Stroke
Interactions	AND, HDAC, HDAC5, INFLAMMATION, KDR, METTL3
KG Connections	38 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HDAC9 — AlphaFold Q9UKV0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HDAC9 Gene

gene · 1563 words

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HDAC9 Protein

protein · 1709 words

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Pathway Diagram

graph TD
    HDAC9["HDAC9"]
    Stroke{"Stroke"}
    HDAC9 -->|"activates"| Stroke
    Ms{"Ms"}
    HDAC9 -->|"therapeutic target"| Ms
    Atherosclerosis{"Atherosclerosis"}
    HDAC9 -->|"activates"| Atherosclerosis
    Inflammation{"Inflammation"}
    HDAC9 -->|"activates"| Inflammation
    INFLAMMATION["INFLAMMATION"]
    HDAC9 -->|"activates"| INFLAMMATION
    neurodegeneration["neurodegeneration"]
    HDAC9 -->|"implicated in"| neurodegeneration
    MEF2D["MEF2D"]
    MEF2D -->|"associated with"| HDAC9
    style HDAC9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

Target	Relation	Type	Str
epigenetic regulation	participates_in	pathway	0.80
Stroke	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Atherosclerosis	activates	disease	0.65
Inflammation	activates	disease	0.65
Inflammation	causes	disease	0.65
Coronary Artery Disease	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
NANOG	activates	gene	0.60
APOE	associated_with	gene	0.60
GENES	associated_with	gene	0.60
RUNX2	associated_with	gene	0.60
neurons	expressed_in	cell_type	0.60
ALDH2	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
INFLAMMATION	associated_with	gene	0.60
STROKE	associated_with	gene	0.60
NRF2	activates	gene	0.60
KDR	activates	gene	0.60
POU5F1	activates	gene	0.60
NRF2	co_expressed_with	gene	0.50

Incoming (14)

Source	Relation	Type	Str
MEF2D	associated_with	gene	0.90
AND	activates	gene	0.60
HDAC5	associated_with	gene	0.60
HDAC5	inhibits	gene	0.60
HDAC5	activates	gene	0.60
HDAC	activates	gene	0.60
MMP12	associated_with	gene	0.60
ATM	associated_with	gene	0.60
HDAC1	regulates	gene	0.60
HDAC3	regulates	gene	0.60
PERICYTE	associated_with	gene	0.60
INFLAMMATION	causes	gene	0.60
METTL3	activates	gene	0.60
HDAC5	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.740

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-14 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap

closed · Rounds: 4 · Score: 0.71 · 2026-04-16

Related Research

Hypotheses and analyses mentioning HDAC9 in their description or question text

No additional research found