SciDEX — NP

Understanding Entity Pages

This page aggregates everything SciDEX knows about NP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Wiki Pages (20)

Outgoing (7)

Target	Relation	Type	Str
ESR1	modulates	gene	0.90
endocrine signaling	associated_with	pathway	0.90
Estrogen	modulates	receptor	0.90
Endocrine System	associated_with	process	0.90
chronic kidney disease	causes	disease	0.88
TNF	binds_to	protein	0.85
Breast Cancer	risk_factor_for	disease	0.85

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (10)

Hypothesis	Score	Disease	Analysis
INPP5D (SHIP1) Inhibition to Shift Microglial Polarization	0.758	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.747	neurodegeneration	Are interneuron oscillation deficits com
H6: Layer II–Specific Loss of NPTX2 and Aberrant AMPAR Traff	0.720	neurodegeneration	Entorhinal cortex layer II vulnerability
hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-002	0.684	molecular neurobiology	View
Microglial P2Y12-Dependent Territorial Segregation of Synapt	0.670	synaptic biology	What determines the selectivity of compl

Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo	0.638	neurodegeneration	CRISPR-based therapeutic approaches for
G3BP1 NTF2L Domain-Mediated mRNP Scaffold Creates Core Exclu	0.633	neurodegeneration	What determines the spatial organization
Surface Exposure of SENP1-β1 Integrin Complex Enables Target	0.550	neurodegeneration	How can senescent microglia be molecular
AAV-mediated RGS6 re-expression in SNpc after pathology onse	0.530	neurodegeneration	Does RGS6 upregulation or D2 autorecepto
Poorly lipidated APOE4 particles are preferentially routed t	0.340	molecular biology	Does APOE4's reduced lipid-binding direc

Hypothesis

Score

Disease

Analysis

INPP5D (SHIP1) Inhibition to Shift Microglial Polarization

0.758

neurodegeneration

TREM2 agonism vs antagonism in DAM micro

C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I

0.747

neurodegeneration

Are interneuron oscillation deficits com

H6: Layer II–Specific Loss of NPTX2 and Aberrant AMPAR Traff

0.720

neurodegeneration

Entorhinal cortex layer II vulnerability

hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-002

0.684

molecular neurobiology

View

Microglial P2Y12-Dependent Territorial Segregation of Synapt

0.670

synaptic biology

What determines the selectivity of compl

Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo

0.638

neurodegeneration

CRISPR-based therapeutic approaches for

G3BP1 NTF2L Domain-Mediated mRNP Scaffold Creates Core Exclu

0.633

neurodegeneration

What determines the spatial organization

Surface Exposure of SENP1-β1 Integrin Complex Enables Target

0.550

neurodegeneration

How can senescent microglia be molecular

AAV-mediated RGS6 re-expression in SNpc after pathology onse

0.530

neurodegeneration

Does RGS6 upregulation or D2 autorecepto

Poorly lipidated APOE4 particles are preferentially routed t

0.340

molecular biology

Does APOE4's reduced lipid-binding direc

Mentioning Analyses (2)

Experiments (1)

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Single-cell RNA sequencing analysis of human atherosclerotic plaques	exploratory	Atherosclerosis	0.900	0.00	Human atherosclerotic plaque s	proposed	N/A

Experiment

Type

Disease

Score

Feasibility

Model

Status

Est. Cost

Single-cell RNA sequencing analysis of human atherosclerotic plaques

exploratory

Atherosclerosis

0.900

0.00

Human atherosclerotic plaque s

proposed

N/A

Related Papers (10)

Title & PMID	Authors	Journal	Year
PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907]	Tsai AP, Martin AK, Mi A, Yeh AE, Ramire	Molecular neurodegeneration	2026
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808]	Sanfilippo C, Castrogiovanni P, Imbesi R	Geroscience	2026
Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 [PMID:41580850]	Xu Z, Chen M, Liang F, Song S, Lei J et	J Transl Med	2026
Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammat [PMID:41633359]	Xie X, Liu J, Liang W, Zhang Y, Gong X e	Immunity	2026
INPP5D/SHIP1-mediated immunometabolic remodeling of renal monocytes in idiopathi [PMID:41853261]	Dai H, Liu B, Rui H, Yang L, Jiang H et	Front Immunol	2026
PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907]	Tsai AP, Martin AK, Mi A, Yeh AE, Ramire	Mol Neurodegener	2026
SHIP-1 adapter functions mediate recruitment of FCRL1 to the BCR and inhibition [PMID:41968726]	Wolfe MM, Tallon Arranz R, Zenni EL, Wil	Immunohorizons	2026
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808]	Sanfilippo C, Castrogiovanni P, Imbesi R	GeroScience	2026
Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammat [PMID:41633359]	Xie X, Liu J, Liang W, Zhang Y, Gong X,	Immunity	2026
Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 [PMID:41580850]	Xu Z, Chen M, Liang F, Song S, Lei J, Hu	Journal of translational medic	2026

NP

Understanding Entity Pages

Wiki Pages (20)

HNRNPA2B1 Protein

Niemann-Pick Disease Type C (NPC)

NPAS3 Gene

Prion Protein (PRNP)

FNP-223 PROSPER Trial - Phase 2 in Progressive Supranuclear Palsy

Outgoing (7)

Incoming (0)

Targeting Hypotheses (10)

Mentioning Analyses (2)

What delivery mechanisms can achieve therapeutically relevant CRISPR concentrati

What determines the specificity of RNA-protein interactions that drive distinct

Experiments (1)

Related Papers (10)

Debates (2)

While the study identifies G3BP1 as a central node triggering phase separation,

All participants identified BBB penetration as a critical bottleneck, but no exi

Related Research

Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention for Severe Neurodevelo

G3BP1 NTF2L Domain-Mediated mRNP Scaffold Creates Core Exclusion Zone for Autoph

Surface Exposure of SENP1-β1 Integrin Complex Enables Targeted Senolytic Elimina

AAV-mediated RGS6 re-expression in SNpc after pathology onset

Poorly lipidated APOE4 particles are preferentially routed through LDLR/LRP1 int

NP

Understanding Entity Pages

Wiki Pages (20)

HNRNPA2B1 Protein

Niemann-Pick Disease Type C (NPC)

NPAS3 Gene

Prion Protein (PRNP)

FNP-223 PROSPER Trial - Phase 2 in Progressive Supranuclear Palsy

Neuropeptide Y (NPY) Neurons

HNRNPA1 Protein

HNRNPR Gene

HNRNPA1 Protein

HNRNPG — Heterogeneous Nuclear Ribonucleoprotein G

FNP-223 PROSPER Trial - Phase 2 in Progressive Supranuclear Palsy

NPTX1 and NPTXR CSF Markers Predict Alzheimer's Disease Progression

HNRNPH2 Gene

NPY5R — Neuropeptide Y Receptor Y5

INPP4A Gene - Inositol Polyphosphate-4-Phosphatase Type I

NPH Glymphatic System Interaction Experiment

HNRNPL Gene

NPRL2 Gene

SNRNP200 Protein

NPRL3 Gene

Outgoing (7)

Incoming (0)

Targeting Hypotheses (10)

Mentioning Analyses (2)

What delivery mechanisms can achieve therapeutically relevant CRISPR concentrati

What determines the specificity of RNA-protein interactions that drive distinct

Experiments (1)

Related Papers (10)

Debates (2)

While the study identifies G3BP1 as a central node triggering phase separation,

All participants identified BBB penetration as a critical bottleneck, but no exi

Related Research

Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention for Severe Neurodevelo

G3BP1 NTF2L Domain-Mediated mRNP Scaffold Creates Core Exclusion Zone for Autoph

Surface Exposure of SENP1-β1 Integrin Complex Enables Targeted Senolytic Elimina

AAV-mediated RGS6 re-expression in SNpc after pathology onset

Poorly lipidated APOE4 particles are preferentially routed through LDLR/LRP1 int