entity

OP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

30Hypotheses

1Analyses

7Outgoing

0Incoming

9Experiments

1Debates

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Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Outgoing (7)

Target	Relation	Type	Str
ESR1	modulates	gene	0.90
endocrine signaling	associated_with	pathway	0.90
Estrogen	modulates	receptor	0.90
Endocrine System	associated_with	process	0.90
chronic kidney disease	causes	disease	0.88
TNF	binds_to	protein	0.85
Breast Cancer	risk_factor_for	disease	0.85

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.958	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore	0.952	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.912	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optimized Temporal Window for Metabolic Boosting Therapy Det	0.887	neurodegeneration	How do different microglial subtypes (DA
APOE-Dependent Autophagy Restoration	0.877	neurodegeneration	Survival Analysis of AD Patient Cohorts:

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.869	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Optogenetic restoration of hippocampal gamma oscillations vi	0.865	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated	0.865	molecular neurobiology	View
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.849	Alzheimer's disease	Circuit-level neural dynamics in neurode
TYROBP (DAP12) Conditional Antagonism for Early-Stage Neurop	0.844	neurodegeneration	Gene Co-expression Network Analysis of A
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
ATM Kinase Hyperactivation Triggers DNA Damage Response Over	0.842	ALS	-
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	View
Closed-loop transcranial focused ultrasound to restore hippo	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.824	neurodegeneration	What are the mechanisms by which gut mic
SIRT1 Activation Couples Mitochondrial Biogenesis to Ferropt	0.824	neurodegeneration	View
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy	0.812	neurodegeneration	View
Neutrophil Extracellular Trap (NET) Inhibition	0.806	-	Blood-brain barrier tight junction disru
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.804	neurodegeneration	What are the mechanisms by which gut mic
Targeting the Mechanistic Link Between AQP4 Dysfunction and	0.803	neurodegeneration	View
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective	0.798	neurodegeneration	View
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	Alzheimer's disease	Circuit-level neural dynamics in neurode
Exposed amyloidogenic segments (β-sheet propensity residues)	0.790	protein biochemistry	Do chaperones selectively recognize path
NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A	0.790	neurodegeneration	epigenetic reprogramming aging neurons
VCP-Mediated Autophagy Enhancement	0.787	neurodegeneration	Tau propagation mechanisms and therapeut
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	Alzheimer's disease	Circuit-level neural dynamics in neurode
TBK1 Loss Triggers Astrocyte-to-Neuron Senescence Propagatio	0.000	ALS	What are the mechanisms by which microgl

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.521

Experiments (9)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	human patients	proposed	N/A
iPSC-NPC effects on astrocytes in vitro ICH model	exploratory	intracerebral hemorrhage	0.900	in vitro ICH cell culture mode	completed	N/A
SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice	validation	Alzheimer's disease	0.900	5xFAD transgenic mice	proposed	N/A
Transcriptomic profiling and differential expression analysis	exploratory	Alzheimer's disease	0.900	1-month-old APP/PS1 mice cereb	proposed	N/A
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	mouse models of Alzheimer's di	proposed	N/A
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	cultured cells under arsenite	proposed	N/A
AMPK knockdown validation experiment	exploratory	intracerebral hemorrhage	0.880	astrocyte cell culture	proposed	N/A
P2RY12-MTOR pathway interaction in VSMCs	exploratory	atherosclerosis	0.850	cultured VSMCs	proposed	N/A
iPSC-NPC transplantation in ICH animal model	validation	intracerebral hemorrhage	0.850	animal ICH model	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
Replating Induces mTOR-Dependent Rescue of Protein Synthesis in Charcot-Marie-To [PMID:41876253]	Koenig J, McGuire A, Homedan Y, Alberhas	eNeuro	2026	0
S-equol promotes ferroptosis in triple negative breast cancer by coordinating NC [PMID:41925800]	Ni F, Huang Z, Cui Y, Huang P, Xue Z, Hu	Molecular and cellular biochem	2026	0
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445]	Qin J, Ma S, Wang J, Huang S, Luan J, He	Cell death & disease	2026	0
Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795]	Gao C, Liu B, Zhang R, Tian J, Xin H	Toxicology mechanisms and meth	2026	0
Metabolic dysregulation reshapes the immune landscape: The gut microbiota-mTOR a [PMID:41445190]	Li J, Li J, Chen K	Mol Ther	2026	0
Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy [PMID:41479169]	Li Z, Yang X, Mao J, Zeng P, Qi Y et al.	Autophagy	2026	0
Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protei [PMID:41529091]	Liu Y, Sun Y, Song TY, Ni SY, Pu YS et a	Cancer Res	2026	0
Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180]	Yang FG, Yang H, Han SW, Wang JT, Gao W	Ageing Res Rev	2026	0
NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890]	Rao W, Huang Y, Li J, Chen Q, Sun J et a	J Stroke Cerebrovasc Dis	2026	0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026	0
Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496]	Che L, Zhu L, Zhou L, Zhou Y	Biochim Biophys Acta Rev Cance	2026	0
mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential [PMID:41789635]	Huo R, Yang Y, Wei C, Yang Y, Meng D et	Int J Mol Med	2026	0
Microcystin-LR-induced phosphorylation imbalance and organelle stress: An integr [PMID:41846138]	Teng Z, Shahzad A, Xu Z, Xia J, Zhang J	J Hazard Mater	2026	0
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570]	Chien Y, Xia R, Zhou D, Ai Y, Wu L et al	Hepatol Commun	2026	0
Copper deficiency impairs oligodendrocyte maturation and social behavior via mit [PMID:41920999]	Usui N, Doi M, Berto S, Matsuoka K, Ishi	Sci Adv	2026	0
Crosstalk between inflammation and autophagy in CeD organoids. [PMID:41933042]	Bellomo C, Furone F, Auricchio R, D'Anie	Sci Rep	2026	0
Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558]	Singh P, Rath SL	Journal of Alzheimer's disease	2026	0
Targeting the AKT/mTOR axis: pectolinarigenin induces autophagy and apoptosis in [PMID:41924135]	Fang Y, Bai J, Bo S, Cui X, Song H, Guo	Frontiers in pharmacology	2026	0
Targeting the GSK-3β/mTOR axis: a novel pharmacological strategy for preeclampsi [PMID:41922823]	Alshaikh ABA, Al-Kuraishy HM, Abdelaziz	Naunyn-Schmiedeberg's archives	2026	0

Debates (1)

Multi-agent debates referencing this entity

The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper d

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning OP in their description or question text

ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia

Score: 0.869 · Alzheimer's Disease · 2026-04-02

## Mechanistic Overview ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia starts from the claim that modu

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Score: 0.865 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Optogenetic restoration of hippocampal gamma oscillations via selective PV interneuron activatio

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV

Score: 0.865 · molecular neurobiology · 2026-04-17

## Mechanistic Overview Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV Interneuron-Spe

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

Score: 0.863 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling a

Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth

Score: 0.849 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and bl

TYROBP (DAP12) Conditional Antagonism for Early-Stage Neuroprotection

Score: 0.844 · neurodegeneration · 2026-04-16

## Mechanistic Overview TYROBP (DAP12) Conditional Antagonism for Early-Stage Neuroprotection starts from the claim that

miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Prot

Score: 0.843 · neurodegeneration · 2026-04-16

## Mechanistic Overview miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Protective Microglia

Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Pre

Score: 0.838 · neurodegeneration · 2026-04-17

## Mechanistic Overview Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents the Self-A

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.827 · Alzheimer's disease · 2026-04-16

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymph

Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuro

Score: 0.824 · neurodegeneration · 2026-04-05

## Mechanistic Overview Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in

SIRT1 Activation Couples Mitochondrial Biogenesis to Ferroptosis Suppression via

Score: 0.824 · neurodegeneration · 2026-04-17

## Mechanistic Overview SIRT1 Activation Couples Mitochondrial Biogenesis to Ferroptosis Suppression via PGC1alpha-Depen

SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent N

Score: 0.812 · neurodegeneration · 2026-04-17

## Mechanistic Overview SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endo

Neutrophil Extracellular Trap (NET) Inhibition

Score: 0.806 · unknown disease · 2026-04-16

## Mechanistic Overview Neutrophil Extracellular Trap (NET) Inhibition starts from the claim that modulating PADI4 withi

Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Release Mechanism for

Score: 0.804 · neurodegeneration · 2026-04-05

## Mechanistic Overview Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Release Mechanism for AIM2 Inflammasom

OP

Understanding Entity Pages

Wiki Pages (21)

18F-OP-801 Ashvattha Neuroinflammation PET Imaging Trial

OPRD1 — Delta-Opioid Receptor

OPTN Protein (Optineurin)

OPTN (Optineurin) Mitophagy Dysfunction — ALS/FTD/PD Causal Chain

OPALIN — Oligodendrocyte Myelin Membrane Protein

OPA1 Protein — Optic Atrophy 1

PAROPE Study - Oculometric Patterns (NCT06597071)

Oligodendrocyte Progenitor Cells (OPCs) - Expanded