gene

CD4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

983Connections

6Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CD4 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 526 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD4
Chromosome	12p13.31.
Protein Family	Immunoglobulin superfamily
Protein Type	Receptor
Function	Binding to MHC class II molecules on antigen-presenting cells
Molecular Weight	55 kDa
Pathways	Amyloid, Apoptosis, Autophagy, Complement, Differentiation
UniProt ID	P01730
NCBI Gene ID	921
Ensembl ID	ENSG00000149257
GeneCards	CD4
Human Protein Atlas	CD4
Associated Diseases	Aging, Als, Alzheimer, Atherosclerosis, Autoimmune
Known Drugs/Compounds	FINGOLIMOD
Interactions	ACTB, AGING, AKK, AKT, Alpha-Synuclein, ALPHA-SYNUCLEIN
KG Connections	981 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CD4 — AlphaFold P01730 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    CD4["CD4
T-helper cell receptor"]
    
    CD4 -->|"regulates"| Neuroinflammation["Neuroinflammation
Process"]
    CD4 -->|"activates"| MS_activation["Multiple Sclerosis
Activation"]
    CD4 -->|"inhibits protective"| ALS_protection["ALS
Neuroprotection"]
    CD4 -->|"regulates"| PD_pathology["Parkinson's Disease
Pathology"]
    CD4 -->|"biomarker"| ALS_progression["ALS
Disease Progression"]
    CD4 -->|"therapeutic target"| MS_treatment["MS
Therapeutic Intervention"]
    
    Neuroinflammation -->|"promotes"| Neurodegeneration["Neurodegeneration
Process"]
    Neuroinflammation -->|"contributes to"| Dementia_risk["Dementia
Risk Development"]
    
    MS_activation -->|"drives"| Autoimmune_response["Autoimmune
Response"]
    MS_activation -->|"leads to"| Myelin_damage["Myelin
Degradation"]
    
    ALS_protection -->|"loss results in"| Motor_neuron_death["Motor Neuron
Degeneration"]
    
    PD_pathology -->|"accelerates"| Dopaminergic_loss["Dopaminergic
Neuron Loss"]
    
    Autoimmune_response -->|"triggers"| CNS_inflammation["CNS
Inflammation"]
    CNS_inflammation -->|"exacerbates"| Neurodegeneration
    
    CD4 -->|"regulates"| Aging_process["Cellular
Aging Process"]
    Aging_process -->|"increases risk"| Neurodegeneration
    
    MS_treatment -->|"targets"| CD4_modulation["CD4+ T-cell
Modulation"]
    CD4_modulation -->|"reduces"| Neuroinflammation
    
    style CD4 fill:#006494
    style MS_treatment fill:#1b5e20
    style CD4_modulation fill:#1b5e20
    style ALS_protection fill:#1b5e20
    style Neuroinflammation fill:#ef5350
    style MS_activation fill:#ef5350
    style Autoimmune_response fill:#ef5350
    style CNS_inflammation fill:#ef5350
    style Neurodegeneration fill:#5d4400
    style Motor_neuron_death fill:#5d4400
    style Dementia_risk fill:#5d4400

Outgoing (717)

Target	Relation	Type	Str
CD4	encodes	protein	0.00
Inflammation	regulates	disease	1.00
Inflammation	activates	disease	1.00
Als	inhibits	disease	0.95
Brain Inflammation	mediates	process	0.95
Als	regulates	disease	0.95
Neurodegeneration	mediates	process	0.95
T CELLS	interacts_with	cell_type	0.95
Parkinson's Disease	contributes_to	disease	0.90
T cells	associated_with	cell_type	0.90
Dopaminergic Cell Loss	causes	phenotype	0.90
Als	activates	disease	0.85
Als	therapeutic_target	disease	0.85
Inflammation	associated_with	disease	0.85
Inflammation	inhibits	disease	0.85
Dementia	associated_with	disease	0.80
T cells	expressed_in	cell_type	0.80
T cells	regulates	cell_type	0.80
Immune Response	activates	pathway	0.80
Immune Response	regulates	pathway	0.80
Tumor	inhibits	disease	0.75
Cancer	associated_with	disease	0.75
Multiple Sclerosis	therapeutic_target	disease	0.75
Autoimmune	therapeutic_target	disease	0.75
Carcinoma	inhibits	disease	0.75
Rheumatoid Arthritis	activates	disease	0.75
Tumor	activates	disease	0.75
Aging	activates	disease	0.75
Als	causes	disease	0.75
Carcinoma	expressed_in	disease	0.75
Parkinson	activates	disease	0.75
Ulcerative Colitis	regulates	disease	0.75
Infection	associated_with	disease	0.75
Aging	associated_with	disease	0.75
Cancer	activates	disease	0.75
Sepsis	activates	disease	0.75
Infection	regulates	disease	0.75
Infection	activates	disease	0.75
Cancer	expressed_in	disease	0.75
Autoimmune	activates	disease	0.75
Als	expressed_in	disease	0.75
Tumor	expressed_in	disease	0.75
Neuroinflammation	inhibits	disease	0.75
Differentiation	activates	pathway	0.70
MICROGLIA	activates	gene	0.70
Mtor	activates	pathway	0.70
NEUROINFLAMMATION	inhibits	gene	0.70
Autophagy	regulates	pathway	0.70
T cells	activates	cell_type	0.70
FOXP3	activates	gene	0.70

Incoming (266)

Source	Relation	Type	Str
CD4	encodes	gene	0.00
INFLAMMATION	activates	gene	1.00
INFLAMMATION	regulates	gene	1.00
VPU	degrades	protein	0.95
PTPN23	mediates	protein	0.85
CD19	associated_with	gene	0.80
AKT	activates	gene	0.80
CD8	associated_with	gene	0.80
PARKINSON'S DISEASE	expressed_in	gene	0.70
FOXP3	activates	gene	0.70
FOXP3	regulates	gene	0.70
INFLAMMATION	associated_with	gene	0.70
CYTOKINES	activates	gene	0.70
CYTOKINES	expressed_in	gene	0.70
tumor	expressed_in	cell_type	0.70
PARKINSON'S DISEASE	activates	gene	0.70
PARKINSON	activates	gene	0.70
GENES	associated_with	gene	0.70
ERK	activates	gene	0.70
CD14	therapeutic_target	gene	0.60
RORC	therapeutic_target	gene	0.60
CSF1R	activates	gene	0.60
CX3CR1	inhibits	gene	0.60
CD8	activates	gene	0.60
CD44	expressed_in	gene	0.60
ADAM10	regulates	gene	0.60
EGFR	regulates	gene	0.60
STAT3	regulates	gene	0.60
JUN	expressed_in	gene	0.60
NPY4R	correlates_with	gene	0.60
CD28	activates	gene	0.60
JAK	inhibits	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.60
PTN	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
MAF	inhibits	gene	0.60
CD8	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
IFN	activates	gene	0.60
TCR	inhibits	gene	0.60
IL-17	activates	gene	0.60
RNA	inhibits	gene	0.60
RAS	activates	gene	0.60

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway	0.772	neurodegeneration	View
Differential Complement Regulator Expression on Synaptic Mem	0.750	synaptic biology	What determines the selectivity of compl
Anti-CD47/SIRPα Checkpoint Therapy to Enhance Phagocytic Cle	0.510	immunomics	Systemic immune profiling in neurodegene
CD44-Mediated Src/PI3K/Akt Signaling Cascade	0.470	neuroinflammation	What molecular mechanisms mediate SPP1-i
Microglial Membrane Camouflage Exploits CD47-SIRPα Checkpoin	0.444	neuroinflammation	How does Alectinib, a kinase inhibitor,

Astrocytic Complement Regulator Secretion Modulates Synaptic	0.000	synaptic biology	What determines the selectivity of compl

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The temporal and stimuli-specific effects of LPS and IFNγ on microglial activati [PMID:41695273]	Heiss CN, Naylor AS, Pesämaa I, Meshi A,	Front Aging Neurosci	2026
CD44 connects autophagy decline and ageing in the vascular endothelium. [PMID:37684253]	Unknown	Nat Commun	2023
The membrane receptor CD44: novel insights into metabolism. [PMID:35249813]	Unknown	Trends Endocrinol Metab	2022
CD44: A Multifunctional Mediator of Cancer Progression. [PMID:34944493]	Unknown	Biomolecules	2021
The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the C [PMID:29519253]	["Matthew L Neal", "Alexa M Boyle", "Kev	Journal of neuroinflammation	2019
HAS2 and CD44 in breast tumorigenesis. [PMID:25081531]	Unknown	Adv Cancer Res	2014

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD4 in their description or question text

Astrocytic Complement Regulator Secretion Modulates Synaptic Vulnerability (CD55

Score: 0.000 · synaptic biology · 2026-04-26

The secretion of soluble complement regulators CD55 and CD46 by reactive astrocytes represents a non-cell-autonomous mec

CD4

Understanding Entity Pages

Summary

Wiki Pages (12)

CD4 Gene

CD47-SIRPα Immune Checkpoint Therapy

CD44 Protein

CD44 - Cell Surface Glycoprotein

Innate Immune Reprogramming: NLRP3 + CD47 Checkpoint Blockade

CD47 Gene

CD4 Protein

CD40 - Cluster of Differentiation 40

CD40 Protein - Cluster of Differentiation 40

CD46

CD47 Protein

CD4/Tfh Help and Germinal-center Memory in Older Adults