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therapeutic 1,461 words KG: ent-gene-f3a46d3d
Contents

CD47-SIRPα Immune Checkpoint Therapy

🔬 Protein Info
Gene SymbolCD47
Full NameSIRPα Immune Checkpoint Therapy
FunctionCD47 is a transmembrane protein that acts as a "don't eat me" signal by binding to SIRPα on macrophages and other phagocytic cells.
Primary Expressionvarious brain regions and cell types, where it contributes to cellular signaling, gene regulation, and homeostasis
Amino Acids323 aa
PathwaysAdaptive Immunity, Amyloid, Apoptosis, Complement, Endocytosis
Ensembl IDENSG00000196776
GeneCardsCD47
Human Protein AtlasCD47
Associated DiseasesAging, Als, Alzheimer, Cancer, Glioblastoma
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ASTROCYTE
KG Connections385 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38TREM2-mediated microglial tau clearance enhancement
Score: 0.59Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48Microbial Inflammasome Priming Prevention
Score: 0.65TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69

Related Analyses (27)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · completedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · completedSynaptic pruning by microglia in early AD
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (9)

Protein expression analysis and cell migration assays in car
exploratory · proposed · Score: 0.88ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40RBG treatment in ApoE-/- atherosclerosis mouse model
validation · proposed · Score: 0.90Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45

See Also (15)

Antibody Therapy in Neurodegeneration
mechanism · Pages share 3 hypothesesAxon Guidance Pathways in Neurodegeneration
mechanism · Pages share 3 hypothesesConvergent Pathways in Neurodegeneration
mechanism · Pages share 3 hypothesesCOVID-19 Neurodegeneration Mechanism
mechanism · Pages share 3 hypothesesDown Syndrome Neurodegeneration Pathway
mechanism · Pages share 3 hypotheses

Knowledge Graph (2 edges)

ent-gene-f3a46d3d data_in benchmark_ot_ad_answer_key:CD47
benchmark_ot_ad_answer_key:CD47 data_in ent-gene-f3a46d3d

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