concept

AREG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AREG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

32Outgoing

15Incoming

0Experiments

0Debates

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💡 Concept Info

Name	AREG
Key Genes/Proteins	Akt, AKT, AND, ANGPT1, App, BANG
Related Diseases	Cancer, Cardiac
Related Pathways	Circadian Rhythm

Pathway Diagram

graph TD
    AREG["AREG"]
    AREG -->|"regulates"| myocardial_injury["myocardial injury"]
    AREG -->|"activates"| PI3K_Akt_GSK_3__pathway["PI3K/Akt/GSK-3beta pathway"]
    AREG -->|"regulates"| Cancer["Cancer"]
    AREG -->|"implicated in"| Tumor["Tumor"]
    AREG -->|"contributes to"| Infection["Infection"]
    AREG -->|"contributes to"| Inflammation["Inflammation"]
    AREG -->|"regulates"| Ms["Ms"]
    AREG -->|"regulates"| Cardiac["Cardiac"]
    BMAL1_HIF2A_complex["BMAL1-HIF2A complex"] -->|"activates"| AREG
    BMAL1["BMAL1"] -->|"activates"| AREG
    DNA["DNA"] -->|"regulates"| AREG
    BANG["BANG"] -->|"regulates"| AREG
    CYTOKINES["CYTOKINES"] -->|"regulates"| AREG
    INFLAMMATION["INFLAMMATION"] -->|"contributes to"| AREG
    EGF["EGF"] -->|"regulates"| AREG

Outgoing (32)

Target	Relation	Type	Str
myocardial injury	regulates	phenotype	0.80
PI3K/Akt/GSK-3β pathway	activates	pathway	0.70
Tumor	implicated_in	disease	0.65
Infection	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Pain	regulates	disease	0.65
CD4	regulates	gene	0.60
BMAL1	regulates	gene	0.60
Rb	regulates	protein	0.60
App	regulates	protein	0.60
BANG	regulates	gene	0.60
HIF2A	targets	gene	0.60
DNA	regulates	gene	0.60
Mapk	associated_with	pathway	0.60
Hif-1	associated_with	protein	0.60
Akt	associated_with	protein	0.60
App	associated_with	protein	0.60
MAPK	associated_with	gene	0.60
ANGPT1	associated_with	gene	0.60
HIF	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
HIF2A	associated_with	gene	0.60
BMAL1	targets	gene	0.60
AND	regulates	gene	0.60
CANCER	regulates	gene	0.60
Circadian Rhythm	regulates	pathway	0.60
PIK3R1	associated_with	gene	0.60
HIF2A	regulates	gene	0.60

Incoming (15)

Source	Relation	Type	Str
BMAL1-HIF2A complex	activates	protein	0.90
BMAL1	activates	gene	0.70
BMAL1	therapeutic_target	gene	0.60
CYTOKINES	regulates	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
EGF	regulates	gene	0.60
GENES	associated_with	gene	0.60
AKT	associated_with	gene	0.60
DNA	regulates	gene	0.60
BMAL1	regulates	gene	0.60
BANG	regulates	gene	0.60
HIF2A	therapeutic_target	gene	0.60
ANGPT1	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
PIK3R1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AREG in their description or question text

No additional research found