gene 625 words KG: CD47
Contents

CD47 Gene

🧬 Gene Info
Gene SymbolCD47
Chromosome3q13.1
FunctionCD47 is a transmembrane protein that acts as a "don't eat me" signal by binding to SIRPα on macrophages and other phagocytic cells.
Primary Expressionvarious brain regions and cell types, where it contributes to cellular signaling, gene regulation, and homeostasis
Amino Acids323 aa
PathwaysAdaptive Immunity, Amyloid, Apoptosis, Complement, Endocytosis
Ensembl IDENSG00000196776
GeneCardsCD47
Human Protein AtlasCD47
Associated DiseasesAging, Als, Alzheimer, Cancer, Glioblastoma
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ASTROCYTE
KG Connections385 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (17)

Microglial Purinergic Reprogramming
Score: 0.70
CYP46A1 Overexpression Gene Therapy
Score: 0.92
SASP-Mediated Complement Cascade Amplification
Score: 0.91
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75

Related Analyses (7)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (1)

Protein expression analysis and cell migration assays in car
exploratory · proposed · Score: 0.88

See Also (5)

Apoptosis in Neurodegeneration
entity · KG edge: regulates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

CX3CR1 regulates CD47
C1Q regulates CD47
CD47 regulates OVERVIEW
S100A8 inhibits CD47
CD47 inhibits GFAP
CD47 inhibits MMP9
CD47 inhibits TNF
CD47 inhibits TLR4
CD47 inhibits CD68
CD47 inhibits MMP2

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