Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TUMOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | AGING, AKT, AKT1, ALZHEIMER'S DISEASE, AMYLOID, APOE, APOPTOSIS, APP |
| KG Connections | 1177 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
TUMOR["TUMOR"]
UBIQUITIN(["UBIQUITIN"])
TUMOR -->|"causes"| UBIQUITIN
ULK1(["ULK1"])
TUMOR -->|"causes"| ULK1
VEGF(["VEGF"])
TUMOR -->|"activates"| VEGF
TP53(["TP53"])
TP53 -->|"associated_with"| TUMOR
MAGI2(["MAGI2"])
MAGI2 -->|"associated_with"| TUMOR
INSULIN_RESISTANCE["INSULIN RESISTANCE"]
INSULIN_RESISTANCE -->|"associated_with"| TUMOR
ER_STRESS["ER STRESS"]
ER_STRESS -->|"associated_with"| TUMOR
style TUMOR fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Mapk | regulates | pathway | 1.00 |
| Metastasis | activates | pathway | 1.00 |
| Microrna | regulates | pathway | 1.00 |
| Differentiation | regulates | pathway | 1.00 |
| Metastasis | regulates | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Toll-Like Receptor | activates | pathway | 1.00 |
| Mitophagy | inhibits | pathway | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Cell Cycle | inhibits | pathway | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Immune Response | associated_with | pathway | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Mapk | inhibits | pathway | 1.00 |
| Nf-Κb | therapeutic_target | pathway | 1.00 |
| Ferroptosis | therapeutic_target | pathway | 1.00 |
| Angiogenesis | inhibits | pathway | 1.00 |
| Angiogenesis | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Pi3K/Akt | inhibits | pathway | 1.00 |
| Metastasis | associated_with | pathway | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Glycolysis | activates | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
| Mtor | regulates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Immune Response | regulates | pathway | 1.00 |
| Breast Cancer | associated_with | disease | 1.00 |
| Tumor Microenvironment | associated_with | pathway | 1.00 |
| Prostate Cancer | associated_with | disease | 1.00 |
| Glioma | associated_with | disease | 1.00 |
| Mapk | therapeutic_target | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Oxidative Stress | inhibits | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Hepatocellular Carcinoma | associated_with | disease | 1.00 |
| Carcinoma | associated_with | disease | 1.00 |
| Epigenetic | regulates | pathway | 1.00 |
| Mtor | inhibits | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| Oxidative Phosphorylation | activates | pathway | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Infection | associated_with | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NF-ΚB | inhibits | gene | 1.00 |
| CANCER | interacts_with | gene | 1.00 |
| NF-ΚB | therapeutic_target | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| FERROPTOSIS | inhibits | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| GPX4 | therapeutic_target | gene | 1.00 |
| CYTOKINES | inhibits | gene | 1.00 |
| C-JUN | activates | gene | 1.00 |
| P53 | regulates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| TP53 | regulates | gene | 1.00 |
| KEAP1 | inhibits | gene | 1.00 |
| ARID1A | associated_with | gene | 1.00 |
| PTEN | inhibits | gene | 1.00 |
| PI3K | expressed_in | gene | 1.00 |
| PIK3CA | associated_with | gene | 1.00 |
| SQSTM1 | therapeutic_target | gene | 1.00 |
| P62 | therapeutic_target | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| VEGF | therapeutic_target | gene | 1.00 |
| TP53 | inhibits | gene | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| CYTOKINES | associated_with | gene | 1.00 |
| MIRNAS | inhibits | gene | 1.00 |
| KRAS | activates | gene | 1.00 |
| P53 | associated_with | gene | 1.00 |
| MYC | associated_with | gene | 1.00 |
| YAP | activates | gene | 1.00 |
| GAIN | associated_with | gene | 1.00 |
| EGFR | associated_with | gene | 1.00 |
| TNF | associated_with | gene | 1.00 |
| DNA | expressed_in | gene | 1.00 |
| APOE | associated_with | gene | 1.00 |
| DNA | associated_with | gene | 1.00 |
| TP53 | associated_with | gene | 1.00 |
| BAX | inhibits | gene | 1.00 |
| AKT | expressed_in | gene | 1.00 |
| LC3 | associated_with | gene | 1.00 |
| GPX4 | activates | gene | 1.00 |
| BCL2 | inhibits | gene | 1.00 |
| KEAP1 | activates | gene | 1.00 |
| EGFR | therapeutic_target | gene | 1.00 |
| GENES | inhibits | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| NRF2 | inhibits | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Tumor-derived extracellular vesicles as TREM2 ligands | 0.490 | neurodegeneration | Does the cancer-cystatin-C-TREM2 pathway |
| Epigenetic Silencing of Tumor Suppressor Genes in Cancer Pro | 0.438 | - | - |
| Direct C1q Binding Enables FcγR-Independent Complement Activ | 0.138 | molecular biology | Does Alectinib truly bind C1q directly w |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TUMOR in their description or question text
No additional research found