gene 828 words KG: CD4
Contents

CD4 Gene

🧬 Gene Info
Gene SymbolCD4
Chromosome12p13.31.
Protein FamilyImmunoglobulin superfamily
Protein TypeReceptor
FunctionBinding to MHC class II molecules on antigen-presenting cells
Molecular Weight55 kDa
PathwaysAmyloid, Apoptosis, Autophagy, Complement, Differentiation
UniProt IDP01730
NCBI Gene ID921
Ensembl IDENSG00000149257
GeneCardsCD4
Human Protein AtlasCD4
Associated DiseasesAging, Als, Alzheimer, Atherosclerosis, Autoimmune
Known Drugs/CompoundsFINGOLIMOD
InteractionsACTB, AGING, AKK, AKT, Alpha-Synuclein, ALPHA-SYNUCLEIN
KG Connections981 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (19)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Ocular Immune Privilege Extension
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Complement C1q Subtype Switching
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (8)

ACTB Gene
gene · KG edge: interacts_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: regulates
AIF1 Gene
gene · KG edge: associated_with
ALDH1L1
gene · KG edge: associated_with
AMBRA1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

JUN regulates CD4
CD4 regulates FOXP3
TGFB1 regulates CD4
CD4 expressed_in STAR
MAF inhibits CD4
CD8 inhibits CD4
CD4 inhibits PRDM1
CD14 therapeutic_target CD4
RORC therapeutic_target CD4
CD4 activates FOXP3

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