gene 1,281 words KG: CREB5
Contents

CREB5 — cAMP Responsive Element Binding Protein 5

🧬 Gene Info
Gene SymbolCREB5
Full NamecAMP Responsive Element Binding Protein 5
Chromosome7p15.1
Protein TypeGene
FunctionLike other CREB family members, CREB5 contains a basic leucine zipper (bZIP) domain that facilitates DNA binding and protein dimerization 5.
Primary Expressionbrain regions involved in learning and memory
PathwaysAngiogenesis, Dna Methylation, Epigenetic
GeneCardsCREB5
Human Protein AtlasCREB5
PhosphorylationCREB5 can be phosphorylated at various residues, affecting its transcriptional activity
Protein-protein interactionsCREB5 interacts with other transcription factors and coactivators
Cellular signaling pathwaysMultiple signaling cascades converge on CREB5 to modulate its function
Associated DiseasesCommon Diseases, Complex Human Diseases
InteractionsFOXO3, MYH7
KG Connections15 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
DNA Methylation
entity · KG edge: regulates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: regulates
Exercise-BDNF-Mitophagy Biomarker Study in PD
experiment · KG edge: regulates
FOXO3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CREB5 activates MYH7
CREB5 activates FOXO3
CREB5 expressed_in Cell Types
CREB5 expressed_in Muscle Fibers
CREB5 associated_with Complex Human Diseases
CREB5 associated_with Common Diseases
CREB5 regulates EXERCISE
CREB5 regulates Als
CREB5 regulates Ms
CREB5 regulates Epigenetic

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