protein 932 words KG: CREB1
Contents

CREB1 Protein

🔬 Protein Info
Gene SymbolCREB1
Full NamecAMP Response Element Binding Protein 1
Chromosome2q33.3
Protein TypeTranscription Factor
FunctionCREB1 is a transcription factor that regulates gene expression in response to cAMP and calcium signaling.
Primary Expressionbrain, with high levels in hippocampus, cortex, and striatum
Subcellular Localization</th><td>Nucleus</td></tr>
Molecular Weight37 kDa
PathwaysApoptosis, CREB signaling, MAPK signaling, Mapk, Oxidative Phosphorylation
UniProt IDP16220
NCBI Gene ID1385
Ensembl IDENSG00000108748
OMIM123810
GeneCardsCREB1
Human Protein AtlasCREB1
Associated DiseasesBreast Cancer, Cancer, neurodegeneration
InteractionsACTB, Actin, AMPK, APOE, APOPTOSIS, APP
KG Connections242 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (12)

Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (8)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
OSK Reprogramming and Yamanaka Factors in Neurodegenera
mechanism · Pages share 5 hypotheses
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 4 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 4 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 4 hypotheses

Knowledge Graph (12 edges)

TRIM27 interacts_with CREB1
CREB1 activates TFEB
CREB1 regulates PIEZO1
REST activates CREB1
P38 activates CREB1
CREB1 activates PPARGC1A
EP300 interacts_with CREB1
MET expressed_in CREB1
CREBBP activates CREB1
BDNF co_discussed CREB1

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