gene 690 words KG: CREB1
Contents

CREB1 Gene

🧬 Gene Info
Gene SymbolCREB1
Full NamecAMP Response Element Binding Protein 1
Chromosome2q33.3
Protein TypeTranscription Factor
FunctionCREB1 is a transcription factor that regulates gene expression in response to cAMP and calcium signaling.
Primary Expressionbrain, with high levels in hippocampus, cortex, and striatum
Molecular Weight37 kDa
PathwaysApoptosis, CREB signaling, MAPK signaling, Mapk, Oxidative Phosphorylation
UniProt IDP16220
NCBI Gene ID1385
Ensembl IDENSG00000108748
OMIM123810
GeneCardsCREB1
Human Protein AtlasCREB1
Associated DiseasesBreast Cancer, Cancer, neurodegeneration
InteractionsACTB, Actin, AMPK, APOE, APOPTOSIS, APP
KG Connections242 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (40)

Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Purinergic Signaling Polarization Control
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
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Related Analyses (13)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (15)

OSK Reprogramming and Yamanaka Factors in Neurodegenera
mechanism · Pages share 6 hypotheses
CALB2 Gene
gene · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
BAX Gene
gene · KG edge: activates
BDNF Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TRIM27 interacts_with CREB1
CREB1 activates TFEB
CREB1 regulates PIEZO1
REST activates CREB1
P38 activates CREB1
CREB1 activates PPARGC1A
EP300 interacts_with CREB1
MET expressed_in CREB1
CREBBP activates CREB1
BDNF co_discussed CREB1

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