concept

EXTRACELLULAR VESICLES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXTRACELLULAR VESICLES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

157Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	EXTRACELLULAR VESICLES
Key Genes/Proteins	AGO2, ALZHEIMER, AMYLOID-BETA, amyotrophic lateral sclerosis, CAV1, CAVEOLIN-1
Related Diseases	cancer, Cardiovascular, disease
Related Pathways	COMPLEMENT

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Extracellular Vesicles in Neurodegeneration

mechanisms · 3331 words

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Pathway Diagram

graph TD
    EXTRACELLULAR_VESICLES["EXTRACELLULAR VESICLES"]
    EXTRACELLULAR_VESICLES -->|"modulates"| Liver["Liver"]
    EXTRACELLULAR_VESICLES -->|"modulates"| Tumor_Microenvironment["Tumor Microenvironment"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Angiogenesis["Angiogenesis"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Intercellular_Communication["Intercellular Communication"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Metabolic_Dysfunction["Metabolic Dysfunction"]
    EXTRACELLULAR_VESICLES -->|"promotes"| dopaminergic_cell_death["dopaminergic cell death"]
    EXTRACELLULAR_VESICLES -.biomarker for.-> Sarcopenia["Sarcopenia"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Mitochondrial_Targeting["Mitochondrial Targeting"]
    candesartan["candesartan"] -->|"inhibits"| EXTRACELLULAR_VESICLES
    GJA1["GJA1"] -->|"regulates"| EXTRACELLULAR_VESICLES
    EXOSOMES["EXOSOMES"] -->|"interacts"| EXTRACELLULAR_VESICLES
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"interacts"| EXTRACELLULAR_VESICLES
    AKT["AKT"] -->|"regulates"| EXTRACELLULAR_VESICLES
    EXTRACELLULAR_MATRIX["EXTRACELLULAR MATRIX"] -.biomarker for.-> EXTRACELLULAR_VESICLES
    CANCER["CANCER"] -->|"activates"| EXTRACELLULAR_VESICLES

Outgoing (50)

Target	Relation	Type	Str
Metastatic Tumor Microenvironment	associated_with	phenotype	0.95
Fatty Liver	expressed_in	disease	0.95
Mitochondria	transports	cell_type	0.95
TARDBP	transports	protein	0.95
Fatty Liver	associated_with	disease	0.95
MAPT	transports	protein	0.95
Microglia	interacts_with	cell_type	0.92
tumor microenvironment	promotes	phenotype	0.92
metastasis	promotes	process	0.90
Angiogenesis	mediates	process	0.90
Liver	modulates	cell_type	0.90
Liver	targets	cell_type	0.90
Tumor Microenvironment	modulates	phenotype	0.90
Intercellular Communication	mediates	process	0.90
miR-206-3p	associated_with	drug	0.90
Metabolic Dysfunction	mediates	phenotype	0.88
metabolic maturation	mediates	phenotype	0.88
angiogenesis	promotes	process	0.87
dopaminergic cell death	promotes	process	0.87
Tumor Metastasis	mediates	process	0.85
Functional Recovery	associated_with	phenotype	0.85
Disease Biomarker	associated_with	biomarker	0.85
Sarcopenia	biomarker_for	disease	0.85
Mitochondrial Targeting	mediates	mechanism	0.85
Mitochondrial Protection	associated_with	process	0.85
Alzheimer Disease	therapeutic_target	disease	0.85
LGALS9	mediates	protein	0.80
immune cell infiltration	mediates	process	0.80
Organ Biodistribution	associated_with	phenotype	0.80
cryptic peptides	expressed_in	compound	0.80
Systemic metabolism	regulates	pathway	0.80
Physiological Functions	associated_with	biological_process	0.80
Immune System	participates_in	biological_process	0.80
Tissue Repair	mediates	process	0.80
Immune Modulation	mediates	process	0.80
amyloid-beta	mediates	compound	0.80
tau	mediates	protein	0.80
Antigen Presentation	participates_in	biological_process	0.80
systemic inflammation	promotes	process	0.78
IL12B	upregulates	gene	0.75
Neurodegeneration	contributes_to	disease	0.75
THBS1	associated_with	protein	0.70
ANGPT1	associated_with	protein	0.70
COL1A1	associated_with	protein	0.70
Drug Delivery	associated_with	biological_process	0.70
phosphorylated tau	mediates	protein	0.70
cell-to-cell communication	regulates	process	0.70
quality control	promotes	process	0.70
Neuroinflammation	modulates	process	0.60
CHRONIC INFLAMMATION	activates	concept	0.50

Incoming (107)

Source	Relation	Type	Str
P2RX7	regulates	gene	0.95
fatty liver	promotes	phenotype	0.95
MIR130A	expressed_in	gene	0.92
TGFB1	expressed_in	protein	0.90
Brown Adipose Tissue	associated_with	cell_type	0.90
ITGAV	targets	gene	0.90
ITGB8	targets	gene	0.90
candesartan	inhibits	drug	0.88
Cancer	associated_with	disease	0.85
cryptic peptides	expressed_in	compound	0.85
hepatic steatosis	associated_with	disease	0.85
Sarcopenia	associated_with	disease	0.85
GJA1	involved_in	gene	0.80
ASTROCYTE	expresses	gene	0.70
motor skill learning	modulates	process	0.70
LRRK2	promotes	protein	0.70
GJA1	regulates	gene	0.70
Sod1	associated_with	gene	0.50
Stem Cell	associated_with	cell_type	0.50
Autophagy	activates	process	0.50
PARKINSON	activates	gene	0.50
Parkinson's Disease	activates	disease	0.50
disease	activates	disease	0.50
PARKINSON'S	activates	concept	0.50
DOPAMINE	activates	concept	0.50
PARKINSON	interacts_with	gene	0.50
PARKINSON'S	interacts_with	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
MITOCHONDRIA	activates	cell_type	0.50
Tdp-43	associated_with	pathway	0.50
IMMUNE RESPONSE	activates	pathway	0.50
NEURONS	activates	concept	0.50
GENE EXPRESSION	activates	concept	0.50
STEM CELLS	activates	concept	0.50
Proteins	interacts_with	protein	0.50
AMYLOID-BETA	activates	protein	0.50
ALZHEIMER	activates	gene	0.50
Neuron	activates	cell_type	0.50
EXOSOMES	activates	concept	0.50
Proteins	expressed_in	protein	0.50
disease	associated_with	disease	0.50
Proteins	regulates	protein	0.50
Cardiovascular	associated_with	disease	0.50
Sod1	activates	gene	0.50
amyotrophic lateral sclerosis	activates	gene	0.50
COMPLEMENT	activates	pathway	0.50
MITOCHONDRIA	regulates	cell_type	0.50
P2RX7	regulates	gene	0.50
Tauopathy	regulates	disease	0.50
microglia	activates	cell_type	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 3: HepaCAM-Containing Extracellular Vesicles	0.762	neurodegeneration	View
Blocking Tau Packaging into Small Extracellular Vesicles via	0.610	neuroscience	Trans-synaptic tau spreading and propaga
Ganglioside-rich extracellular vesicles preserve alpha-synuc	0.582	neurodegeneration	Which specific CSF molecular components
Tumor-derived extracellular vesicles as TREM2 ligands	0.490	neurodegeneration	Does the cancer-cystatin-C-TREM2 pathway

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EXTRACELLULAR VESICLES in their description or question text

No additional research found