gene

RAC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

0Analyses

16Outgoing

19Incoming

0Experiments

0Debates

Summary

Page for RAC2 — RAS-Related C3 Botulinum Toxin Substrate 2

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🧬 Gene Info

Gene Symbol	RAC2
Full Name	RAS-Related C3 Botulinum Toxin Substrate 2
Chromosome	22q13.1
Function	RAC2 is a small GTPase belonging to the Rho family.
Primary Expression	hematopoietic cells but also has significant expression in the nervous system, particularly in neurons and [microglia](/cell-type
Molecular Weight	21.4 kDa
Amino Acids	192 aa
UniProt ID	P15153
NCBI Gene ID	5879
Ensembl ID	ENSG00000128340
OMIM	602049
GeneCards	RAC2
Human Protein Atlas	RAC2
GTPase domain	Binds GTP/GDP and has intrinsic GTPase activity
Effector region	Interacts with downstream targets
Associated Diseases	Atherosclerosis, Ms
Interactions	ACTB, CAT, CCL5, CD19, CD4, CDK4
KG Connections	35 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAC2 — AlphaFold P15153 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RAC2 — RAS-Related C3 Botulinum Toxin Substrate 2

gene · 621 words

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RAC2 Protein

protein · 1517 words

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Pathway Diagram

graph TD
    RAC2["RAC2"]
    Ms{"Ms"}
    RAC2 -->|"associated with"| Ms
    Atherosclerosis{"Atherosclerosis"}
    RAC2 -->|"associated with"| Atherosclerosis
    RAC2 -->|"regulates"| Ms
    Autism{"Autism"}
    RAC2 -->|"regulates"| Autism
    COL1A1["COL1A1"]
    RAC2 -->|"associated with"| COL1A1
    CTSD["CTSD"]
    RAC2 -->|"associated with"| CTSD
    MAF["MAF"]
    RAC2 -->|"associated with"| MAF
    RAC2 -->|"interacts with"| CTSD
    CDK4["CDK4"]
    RAC2 -->|"interacts with"| CDK4
    CDKN1A["CDKN1A"]
    RAC2 -->|"interacts with"| CDKN1A
    LCK["LCK"]
    RAC2 -->|"interacts with"| LCK
    Mapk(["Mapk"])
    RAC2 -->|"interacts with"| Mapk
    IBSP["IBSP"]
    IBSP -->|"associated with"| RAC2
    MIRNAS["MIRNAS"]
    MIRNAS -->|"expressed in"| RAC2
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"expressed in"| RAC2
    CD4["CD4"]
    CD4 -->|"interacts with"| RAC2
    MAPK3["MAPK3"]
    MAPK3 -->|"interacts with"| RAC2
    ZAP70["ZAP70"]
    ZAP70 -->|"interacts with"| RAC2
    TP53["TP53"]
    TP53 -->|"interacts with"| RAC2
    MIRNAS -->|"regulates"| RAC2
    CD19["CD19"]
    CD19 -->|"interacts with"| RAC2
    EEF2["EEF2"]
    EEF2 -->|"interacts with"| RAC2
    CCL5["CCL5"]
    CCL5 -->|"interacts with"| RAC2
    TNF["TNF"]
    TNF -->|"interacts with"| RAC2
    style RAC2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:RAC2	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Ms	regulates	disease	0.65
Autism	regulates	disease	0.65
Mapk	interacts_with	pathway	0.60
COL1A1	associated_with	gene	0.60
MIRNAS	expressed_in	gene	0.60
IBSP	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
MAF	associated_with	gene	0.60
CTSD	interacts_with	gene	0.60
CDK4	interacts_with	gene	0.60
CDKN1A	interacts_with	gene	0.60
LCK	interacts_with	gene	0.60

Incoming (19)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:RAC2	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
IBSP	associated_with	gene	0.60
MIRNAS	expressed_in	gene	0.60
MICRORNAS	expressed_in	gene	0.60
MIRNAS	regulates	gene	0.60
GENES	associated_with	gene	0.60
CD4	interacts_with	gene	0.60
MAPK3	interacts_with	gene	0.60
ZAP70	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
CD19	interacts_with	gene	0.60
EEF2	interacts_with	gene	0.60
CCL5	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
TLR7	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
MAF	associated_with	gene	0.60
ACTB	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAC2 in their description or question text

No additional research found