gene

MAF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

195Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Comprehensive information about MAF transcription factor, its role in cellular homeostasis, stress response, and implications for neurodegenerative diseases including Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	MAF
Full Name	MAFA BZIP Transcription Factor[@yoshida2012]
Chromosome	16q22.1
Protein Type	Transcription Factor
Function	is a member of the MAF family of transcription factors, belonging to the larger AP-1 superfamily of basic leucine zipper (bZIP) proteins.
Molecular Weight	42 kDa
Amino Acids	370 aa
Pathways	Co-inhibitory Gene Module, Endocytosis
UniProt ID	Q9UHV9
NCBI Gene ID	4094
Ensembl ID	ENSG00000185340
OMIM	610266
GeneCards	MAF
Human Protein Atlas	MAF
Associated Diseases	Als, Alzheimer, Atherosclerosis, Autoimmune, Cancer
Interactions	ABCA7, AKT, AND, APOPTOSIS, ATP, BRAF
KG Connections	195 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MAF — AlphaFold Q9UHV9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAF["MAF"]
    MAF -->|"inhibits"| Cancer["Cancer"]
    MAF -->|"inhibits"| Als["Als"]
    MAF -->|"regulates"| Leukemia["Leukemia"]
    MAF -->|"activates"| Carcinoma["Carcinoma"]
    MAF -->|"activates"| Tumor["Tumor"]
    MAF -->|"activates"| Ms["Ms"]
    C1Q["C1Q"] -->|"regulates"| MAF
    GAIN["GAIN"] -->|"target for"| MAF
    CD4["CD4"] -->|"activates"| MAF
    CD8["CD8"] -->|"activates"| MAF
    MTOR["MTOR"] -->|"activates"| MAF
    MERTK["MERTK"] -->|"activates"| MAF
    AKT["AKT"] -->|"activates"| MAF
    APOPTOSIS["APOPTOSIS"] -->|"activates"| MAF
    P62["P62"] -->|"activates"| MAF
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| MAF

Outgoing (123)

Target	Relation	Type	Str
Co-inhibitory Gene Module	regulates	pathway	0.90
Fibrosis	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Als	regulates	disease	0.65
Ms	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Ischemia	expressed_in	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Leukemia	encodes	disease	0.65
ALS	associated_with	disease	0.65
Als	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Als	activates	disease	0.65
Lymphoma	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Macular Degeneration	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Leukemia	regulates	disease	0.65
Als	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	activates	disease	0.65
ALS	inhibits	disease	0.65
Ferroptosis	activates	pathway	0.60
DNA	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
ACHE	associated_with	gene	0.60
Akt	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Mtor	activates	pathway	0.60
Sphingolipid	activates	pathway	0.60
Cholesterol	activates	pathway	0.60

Incoming (72)

Source	Relation	Type	Str
PRDM1	interacts_with	gene	0.85
ZCWPW1	associated_with	gene	0.60
EGFR	activates	gene	0.60
TNF	regulates	gene	0.60
ABCA7	interacts_with	gene	0.60
endocytosis	activates	process	0.60
APOPTOSIS	activates	gene	0.60
AND	associated_with	gene	0.60
IL-10	activates	gene	0.60
LDL	activates	gene	0.60
GENES	associated_with	gene	0.60
PILRA	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
ATP	activates	gene	0.60
RNA	expressed_in	gene	0.60
apoptosis	inhibits	pathway	0.60
LXR	activates	gene	0.60
GAIN	therapeutic_target	gene	0.60
CD4	activates	gene	0.60
CD8	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CD8	inhibits	gene	0.60
ATF6	associated_with	gene	0.60
CD4	inhibits	gene	0.60
KEAP1	regulates	gene	0.60
P62	regulates	gene	0.60
FERROPTOSIS	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
C-FOS	regulates	gene	0.60
IBSP	associated_with	gene	0.60
MIRNAS	expressed_in	gene	0.60
MICRORNAS	expressed_in	gene	0.60
COL1A1	associated_with	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
CANCER	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
VIRAL INFECTIONS	inhibits	gene	0.60
IRF8	activates	gene	0.60
C1Q	regulates	gene	0.60
MTOR	activates	gene	0.60
MERTK	activates	gene	0.60
AKT	activates	gene	0.60
P62	activates	gene	0.60
KEAP1	activates	gene	0.60
KEAP1	therapeutic_target	gene	0.60
FOS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAF in their description or question text

No additional research found

MAF