gene 1,478 words KG: CDK1
Contents

CDK1 — Cyclin-Dependent Kinase 1

🧬 Gene Info
Gene SymbolCDK1
Full NameCyclin-Dependent Kinase 1
Chromosome10q21.1
Protein TypeKinase
Functionis a gene located on chromosome 10q21.
Primary ExpressionUbiquitous (neurons, glia, proliferating cells)
Molecular Weight34 kDa
Amino Acids297 aa
PathwaysAngiogenesis, Autophagy, Cell Cycle, Differentiation, Epigenetic
UniProt IDP06493
NCBI Gene ID983
Ensembl IDENSG00000164946
OMIM176741
GeneCardsCDK1
Human Protein AtlasCDK1
Associated DiseasesALS, Cancer, Inflammation
Known Drugs/Compoundsrapamycin
InteractionsACTB, Akt, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections336 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Circadian Clock-Autophagy Synchronization
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Extracellular Matrix Stiffness Modulation
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (12)

blarcamesine-axon
clinical_trial · KG edge: regulates
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
ALDH2 — Aldehyde Dehydrogenase 2
gene · KG edge: regulates
AMBRA1 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

BMAL1 activates CDK1
CDK1 regulates ARNT
CDK1 regulates CLOCK
CDK1 therapeutic_target BRAF
CDK1 inhibits BECN1
BRAF therapeutic_target CDK1
ARNT regulates CDK1
CDK1 inhibits APP
CDK1 inhibits TAU
CDK1 activates CDK5

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