| Gene Symbol | CDK16 |
| Full Name | Cyclin-Dependent Kinase 16 (PCTAIRE-1) |
| Aliases | PCTAIRE-1 |
| Function | CDK16/PCTAIRE-1 is a unique member of the CDK family characterized by its testis-specific cyclin binding and predominantly neuronal expression pattern. |
| Primary Expression | substantia nigra 5 |
| Ensembl ID | ENSG00000103150 |
| GeneCards | CDK16 |
| Human Protein Atlas | CDK16 |
| Kinase Domain | Canonical serine/threonine kinase domain |
| PSTAIRE-like Motif | Cyclin-binding motif in the cyclin-binding domain |
| Unique C-terminal Region | Specific to PCTAIRE subfamily |
| Dopaminergic neuron vulnerability | CDK16 is highly expressed in dopaminergic neurons of the substantia nigra, the neurons most vulnerable in Parkinson's disease |
| Single-cell analysis | Confirmed CDK16 expression in dopaminergic neuron populations |
| Synaptic dysfunction | Regulates synaptic vesicle cycling, dysfunction contributes to dopaminergic synaptic deficits |
| Alpha-synuclein connection | May phosphorylate proteins involved in alpha-synuclein processing[@suzuki2020] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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