| Gene Symbol | CDK12 |
| Full Name | Cyclin-Dependent Kinase 12 |
| Protein Type | Kinase |
| Function | CDK12 is a serine/threonine kinase that forms a complex with cyclin K to phosphorylate the C-terminal domain (CTD) of RNA polymerase II. |
| Primary Expression | all CA regions - Motor Cortex: High expression in upper motor neurons - Spinal Cord: Present in motor neurons - Cerebellum: Moderate expre |
| Molecular Weight | 164 kDa |
| Pathways | Autophagy, Epigenetic |
| Ensembl ID | ENSG00000167258 |
| GeneCards | CDK12 |
| Human Protein Atlas | CDK12 |
| Kinase Domain | C-terminal serine/threonine kinase domain |
| Cyclin-Binding Region | N-terminal region for cyclin K interaction |
| RS-Rich Region | Arginine-serine rich region involved in RNA processing |
| Associated Diseases | PULMONARY_FUNCTION |
| Interactions | ARAF, ATG12, ATG16L1, ATG3, ATG7, ATG9A |
| KG Connections | 42 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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