gene

CDK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

243Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CDK2 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with ALS, Aging, Als. Connected to 120 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CDK2
Full Name	Cyclin-Dependent Kinase 2
Chromosome	12q13.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	34 kDa
Amino Acids	297 aa
Exons	9
Pathways	Cell Cycle, Cell Division
UniProt ID	P24941
NCBI Gene ID	1017
Ensembl ID	ENSG00000145386
GeneCards	CDK2
Human Protein Atlas	CDK2
Associated Diseases	Aging, ALS, Cancer, Gastric Cancer, Ms, Neurodegeneration
Known Drugs/Compounds	Thiabendazole
Interactions	Actin, AGING, AKT, AND, APC, App
KG Connections	243 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CDK2 — AlphaFold P24941 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CDK2 Gene

gene · 809 words

→

CDK2 Protein

protein · 656 words

→

Pathway Diagram

graph TD
    CDK2["CDK2"]
    CDK2 -->|"activates"| Cancer["Cancer"]
    CDK2 -->|"activates"| Ms["Ms"]
    CDK2 -->|"activates"| Als["Als"]
    CDK2 -->|"target for"| Carcinoma["Carcinoma"]
    CDK2 -->|"expressed in"| Glioblastoma["Glioblastoma"]
    JUN["JUN"] -->|"inhibits"| CDK2
    CDH1["CDH1"] -->|"activates"| CDK2
    DNA["DNA"] -->|"activates"| CDK2
    APC["APC"] -->|"activates"| CDK2
    BAX["BAX"] -->|"expressed in"| CDK2
    CDK1["CDK1"] -->|"activates"| CDK2
    EGFR["EGFR"] -->|"expressed in"| CDK2
    BCL_2["BCL-2"] -->|"expressed in"| CDK2
    APOPTOSIS["APOPTOSIS"] -->|"expressed in"| CDK2

Outgoing (159)

Target	Relation	Type	Str
TRIM32	phosphorylates	protein	0.95
Cell Cycle Entry	activates	process	0.90
radioresistance	promotes	phenotype	0.88
Oncogene-Induced Senescence	involved_in	process	0.85
E2F Transcription Program	activates	pathway	0.85
Microvascular Anomalies	mediates	phenotype	0.85
prostate cancer	promotes	disease	0.82
gastric cancer	promotes	disease	0.82
Liver Injury	involved_in	disease	0.80
cell cycle entry	promotes	process	0.80
Gastric Cancer	associated_with	disease	0.80
Microvascular Anomalies	involved_in	phenotype	0.80
telomere shortening	regulates	process	0.75
Als	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	regulates	disease	0.75
EGFR	coexpressed_with	gene	0.75
Cell Cycle	activates	pathway	0.70
Neurodegeneration	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Aging	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Inflammation	treats	disease	0.65
Als	treats	disease	0.65
Aging	activates	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	activates	disease	0.65
Ms	associated_with	disease	0.65
Infection	regulates	disease	0.65
Als	regulates	disease	0.65
Viral Infection	regulates	disease	0.65
Retinopathy	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Obesity	causes	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	interacts_with	disease	0.65
Lipid Metabolism	interacts_with	pathway	0.60
Erk	activates	protein	0.60
ALS	associated_with	disease	0.60

Incoming (84)

Source	Relation	Type	Str
FTO	targets	protein	0.95
Thiabendazole	binds	drug	0.90
XHP	downregulates	drug	0.90
JUN	inhibits	gene	0.90
Thiabendazole	binds_to	drug	0.88
APC/C(CDH1)	regulates	enzyme	0.85
Lactylation	regulates	process	0.75
EGFR	activates	gene	0.60
HTT	inhibits	gene	0.60
HUNTINGTIN	inhibits	gene	0.60
AGING	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
P53	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
APC	activates	gene	0.60
ROS	expressed_in	gene	0.60
GENES	activates	gene	0.60
DIABETIC RETINOPATHY	causes	gene	0.60
P53	activates	gene	0.60
CCND1	targets	gene	0.60
FYN	associated_with	gene	0.60
MAPK3	associated_with	gene	0.60
PAK1	associated_with	gene	0.60
APC	inhibits	gene	0.60
FTO	causes	gene	0.60
AGING	activates	gene	0.60
FZR1	activates	gene	0.60
MAPK8	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
DIABETIC RETINOPATHY	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
NEUROTOXICITY	inhibits	gene	0.60
P21	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
AND	inhibits	gene	0.60
CANCER	activates	gene	0.60
AND	causes	gene	0.60
P21	activates	gene	0.60
GENES	expressed_in	gene	0.60
GSK3	inhibits	gene	0.60
JUN	activates	gene	0.60
BAX	expressed_in	gene	0.60
CDK1	activates	gene	0.60
EGFR	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDK2 in their description or question text

No additional research found