protein

IL-1Β

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-1Β: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

367Connections

9Hypotheses

3Analyses

50Outgoing

50Incoming

1Experiments

3Debates

Summary

Page for IL-1β Protein

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🔬 Protein Info

Gene Symbol	IL
Function	Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation.
GeneCards	IL
Human Protein Atlas	IL
Associated Diseases	CRC
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    IL_1_["IL-1Beta"]
    Parkinson_s_Disease{"Parkinson's Disease"}
    IL_1_ -->|"biomarker_for"| Parkinson_s_Disease
    Neuroinflammation["Neuroinflammation"]
    IL_1_ -->|"contributes_to"| Neuroinflammation
    Liver_Fibrosis{"Liver Fibrosis"}
    IL_1_ -->|"contributes_to"| Liver_Fibrosis
    Neurodegeneration["Neurodegeneration"]
    IL_1_ -->|"biomarker_for"| Neurodegeneration
    Hepatic_Stellate_Cell_Activati["Hepatic Stellate Cell Activation"]
    IL_1_ -->|"associated_with"| Hepatic_Stellate_Cell_Activati
    Spinal_Cord_Injury_Inflammatio["Spinal Cord Injury Inflammation"]
    IL_1_ -->|"mediates"| Spinal_Cord_Injury_Inflammatio
    NLRP3_INFLAMMASOME(["NLRP3 INFLAMMASOME"])
    NLRP3_INFLAMMASOME -->|"associated_with"| IL_1_
    Ua["Ua"]
    Ua -.->|"downregulates"| IL_1_
    NLRP3["NLRP3"]
    NLRP3 -->|"activates"| IL_1_
    NLRP3_Inflammasome_Activation["NLRP3 Inflammasome Activation"]
    NLRP3_Inflammasome_Activation -->|"associated_with"| IL_1_
    style IL_1_ fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (197)

Target	Relation	Type	Str
Neuroinflammation	contributes_to	process	0.95
Innate Immune Memory	associated_with	process	0.95
NF-kB	activates	protein	0.90
ST6GAL1	contributes_to	gene	0.90
Neuroinflammation	mediates	process	0.90
NEURON	associated_with	cell_type	0.90
Chondrocyte Viability	inhibits	phenotype	0.90
INFLAMMATION	promotes	process	0.90
NLRP3	activates	protein	0.90
Epigenetic Changes	modulates	mechanism	0.89
Synaptic Dysfunction	causes	process	0.88
Pro-Inflammatory Phenotype	associated_with	phenotype	0.85
Ovary Inflammation	promotes	process	0.85
Parkinson's Disease	biomarker_for	disease	0.85
Liver Fibrosis	contributes_to	disease	0.85
Neuroinflammation	mediates	process	0.85
Traumatic Brain Injury	biomarker_for	disease	0.85
Neuroinflammation	contributes_to	process	0.85
Neurodegeneration	promotes	phenotype	0.85
Ulcerative Colitis	biomarker_for	disease	0.85
Myeloid Cell Immune Response	mediates	process	0.85
Neurodegeneration	biomarker_for	process	0.82
Neuroinflammation	promotes	process	0.80
Alzheimer's Disease	contributes_to	disease	0.80
Spinal Cord Injury Inflammation	mediates	process	0.80
H2S	upregulates	compound	0.80
Status Epilepticus	biomarker_for	disease	0.80
Hepatic Stellate Cell Activation	associated_with	process	0.80
neurons	damages	cell_type	0.80
innate immune memory	drives	process	0.80
STROKE	promotes	disease	0.80
neuroprotective effects of Quercetin	inhibits	process	0.80
TDP-43 pathology	biomarker_for	phenotype	0.70
TDP-43 pathology	associated_with	phenotype	0.70
TDP-43 cytoplasmic accumulation	causes	mechanism	0.70
neuroinflammation	activates	process	0.70
Alzheimer's disease	associated_with	disease	0.70
epilepsy	associated_with	disease	0.70
M1 pro-inflammatory phenotype	biomarker_for	cell_type	0.70
Cholesterol	activates	pathway	0.50
NEURONS	activates	concept	0.50
Infection	activates	disease	0.50
GASDERMIN D	associated_with	protein	0.50
CELL DEATH	associated_with	concept	0.50
GASDERMIN	associated_with	gene	0.50
CYTOKINE	associated_with	concept	0.50
IL-1	associated_with	concept	0.50
PARKINSON	activates	gene	0.50
Parkinson's Disease	activates	disease	0.50
Neurodegenerative Diseases	activates	disease	0.50

Incoming (170)

Source	Relation	Type	Str
Berberine	inhibits	compound	0.95
HSYA	downregulates	compound	0.95
secretory autophagy	regulates	process	0.95
NLRP3	upstream_of	protein	0.95
Cerebral Ischemia-Reperfusion Injury	upregulates	disease	0.92
Fingolimod	downregulates	drug	0.92
NLRP3	produces	protein	0.90
NLRP3 INFLAMMASOME	associated_with	protein	0.90
TLR4	upregulates	protein	0.90
Ciprofloxacin	downregulates	drug	0.90
Indirubin	downregulates	compound	0.90
NLRP3	activates	gene	0.90
NLRP3	upregulates	protein	0.90
NLRP3	activates	entity	0.90
Ua	downregulates	compound	0.90
canakinumab	inhibits	drug	0.90
32505187	was increased in	paper	0.90
miR-369-3p	downregulates	biomarker	0.90
pyroptosis	promotes	process	0.90
NLRP3 Inflammasome	associated_with	mechanism	0.90
NLRP3	regulates	gene	0.90
Microglia	produces	cell_type	0.90
DS-HMGB1	upregulates	protein	0.90
Gallic Acid	downregulates	compound	0.90
NLRP3	upregulates	protein	0.90
NLRP3 Inflammasome Activation	associated_with	process	0.90
37245027	induces	paper	0.90
37245027	induces reduction of	paper	0.90
Bergenin	downregulates	compound	0.90
NLRP3 Inflammasome Activation	activates	process	0.90
CASP1	activates	protein	0.90
DHT	downregulates	compound	0.90
PS-COOH	upregulates	compound	0.90
NLRP3 Inflammasome	upregulates	mechanism	0.88
NF-κB	upregulates	pathway	0.88
Palmitoleic Acid	downregulates	compound	0.85
Nf-Κb	regulates	protein	0.85
BIG1	upregulates	gene	0.85
Guhan Yangsheng Jing	downregulates	drug	0.85
cGAS-STING	upregulates	pathway	0.85
NF-κB	regulates	protein	0.85
NLRP3	regulates	protein	0.85
IL-17 Signaling Pathway	upregulates	pathway	0.85
MIR-369-3P	downregulates	gene	0.85
S1PR1	promotes	protein	0.85
NF-κB signaling pathway	upstream_of	pathway	0.85
Ischemia	upregulates	disease	0.85
Rutin	downregulates	compound	0.85
NLRP3	activates	gene	0.80
TAU	upregulates	protein	0.80

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S	0.663	cell biology	What is the relative contribution of con
Astrocyte IL-1β as Paracrine Mediator of Microglial Compleme	0.658	neuroinflammation	How does sevoflurane-induced NF-κB activ
NLRP3 Inflammasome Priming Converts SCFA-Sensitive Pyroptosi	0.620	neurodegeneration	How does gut microbiome dysbiosis contri
LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasom	0.617	neurodegeneration	How do perivascular cells specifically r
NLRP3 Inflammasome Inhibition Prevents Synapse Loss via IL-1	0.610	neurodegeneration	Test Preregistration Analysis

Circulating hs-CRP as Disease-Modifying Target via Microglia	0.565	immunomics	Systemic immune profiling in neurodegene
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.506	neuroinflammation	Why do TAM receptors protect against neu
CRP-Mediated CCR2+ Monocyte Recruitment Drives Microglial IL	0.380	immunomics	Systemic immune profiling in neurodegene
hs-CRP-Driven CCR2+ Monocyte Recruitment Disrupts CNS Immune	0.357	immunomics	Systemic immune profiling in neurodegene

Mentioning Analyses (3)

Scientific analyses that reference this entity

Do SPM receptors undergo desensitization with chronic agonist treatment, prevent

pharmacology | 2026-04-11 | 0 hypotheses

How does APOE4 mechanistically increase TDP-43 pathology frequency in Alzheimer'

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.580

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.618

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Network pharmacology analysis of QTJD active compounds and pathways	exploratory	Mycoplasma pneumoniae pneumoni	0.900	0.00	computational network analysis	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

closed · Rounds: 4 · Score: 0.67 · 2026-04-22

The abstract identifies APOE4 association with increased TDP-43 pathology but th

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

The debate highlighted receptor desensitization as a critical concern for SPM re

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning IL-1Β in their description or question text

Circulating hs-CRP as Disease-Modifying Target via Microglial IL-1β Amplificatio

Score: 0.565 · immunomics · 2026-04-25

Circulating hs-CRP as Disease-Modifying Target via Microglial IL-1β Amplification

TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Function by Suppressing IL-

Score: 0.506 · neuroinflammation · 2026-04-14

## Mechanistic Overview TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Function by Suppressing IL-1β-Mediated Infl

CRP-Mediated CCR2+ Monocyte Recruitment Drives Microglial IL-1β Amplification an

Score: 0.380 · immunomics · 2026-04-27

This hypothesis proposes that circulating hs-CRP directly recruits CCR2+ monocytes to the CNS through upregulation of CC

hs-CRP-Driven CCR2+ Monocyte Recruitment Disrupts CNS Immune Privilege via IL-1β

Score: 0.357 · immunomics · 2026-04-26

Circulating hs-CRP directly triggers CCR2+ monocyte recruitment to the CNS by enhancing CCL2 expression in brain endothe