protein

IRISIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRISIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

119Connections

0Hypotheses

0Analyses

50Outgoing

21Incoming

0Experiments

0Debates

Summary

Page for Irisin — Exercise-Induced Myokine

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🔬 Protein Info

Gene Symbol	IRISIN
Function	Irisin acts as a systemic mediator, conveying the benefits of exercise to distant tissues including the brain.
Molecular Weight	12 kDa
Amino Acids	112 aa
Pathways	Mitochondrial Function, Synaptic Plasticity
GeneCards	IRISIN
Human Protein Atlas	IRISIN
Associated Diseases	Alzheimer'S Disease, DIABETES, disease, Insulin Sensitivity, Neurodegenerative Diseases, OBESITY
Interactions	ALZHEIMER, AMPK, AMYLOID, BDNF, BMP2, FGF2
KG Connections	80 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Irisin Therapy — Exercise-Induced Myokine for Neurodegeneration

therapeutic · 1520 words

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Pathway Diagram

graph TD
    IRISIN("IRISIN")
    FNDC5["FNDC5"]
    FNDC5 -->|"encodes"| IRISIN
    Angiogenesis["Angiogenesis"]
    IRISIN -->|"associated_with"| Angiogenesis
    Fracture_Healing["Fracture Healing"]
    IRISIN -->|"associated_with"| Fracture_Healing
    Insulin_Sensitivity["Insulin Sensitivity"]
    IRISIN -->|"associated_with"| Insulin_Sensitivity
    Osteogenesis["Osteogenesis"]
    IRISIN -->|"associated_with"| Osteogenesis
    NFKB("NFKB")
    IRISIN -->|"inhibits"| NFKB
    Inflammation["Inflammation"]
    IRISIN -->|"associated_with"| Inflammation
    Bone_Formation["Bone Formation"]
    IRISIN -->|"associated_with"| Bone_Formation
    Bone_Fracture_Healing["Bone Fracture Healing"]
    IRISIN -->|"associated_with"| Bone_Fracture_Healing
    Mitochondrial_Function["Mitochondrial Function"]
    IRISIN -->|"associated_with"| Mitochondrial_Function
    Oxidative_Stress["Oxidative Stress"]
    IRISIN -->|"associated_with"| Oxidative_Stress
    Osteoporosis{"Osteoporosis"}
    IRISIN -->|"protects_against"| Osteoporosis
    Amyloid_Beta_Toxicity["Amyloid-Beta Toxicity"]
    IRISIN -->|"associated_with"| Amyloid_Beta_Toxicity
    BDNF("BDNF")
    IRISIN -->|"associated_with"| BDNF
    Type_2_Diabetes{"Type 2 Diabetes"}
    IRISIN -->|"treats"| Type_2_Diabetes

Outgoing (98)

Target	Relation	Type	Str
ITGAV	binds_to	gene	0.95
Angiogenesis	promotes	process	0.95
Fracture Healing	associated_with	process	0.95
Osteogenesis	activates	process	0.95
Neuroinflammation	associated_with	process	0.95
Angiogenesis	associated_with	process	0.95
Bone Fracture Healing	associated_with	process	0.95
NLRP3	inhibits	protein	0.95
Angiogenesis	activates	process	0.95
ITGB5	binds_to	gene	0.95
Fracture Healing	promotes	process	0.95
Osteogenesis	promotes	process	0.95
BMP2	upregulates	gene	0.90
Callus Mineralization	promotes	phenotype	0.90
VEGF	upregulates	gene	0.90
CD31	upregulates	gene	0.90
Bone Formation	associated_with	process	0.90
Osteogenic Differentiation	activates	process	0.90
Insulin Sensitivity	associated_with	phenotype	0.90
Osteogenesis	associated_with	process	0.90
NFKB	inhibits	protein	0.90
Inflammation	associated_with	process	0.90
Bone Fracture Healing	associated_with	process	0.90
TFEB	activates	protein	0.90
Parkinson's Disease	protects_against	disease	0.90
Neuroinflammation	inhibits	process	0.90
ARG1	upregulates	gene	0.90
CASP1	downregulates	gene	0.85
depression	protects_against	disease	0.85
IL1B	downregulates	gene	0.85
M2 Polarization	associated_with	process	0.85
Bone Fracture Healing	treats	disease	0.85
Bone Formation	associated_with	process	0.85
Mesenchymal Stem Cells	modulates	cell_type	0.85
Mesenchymal Stem Cells	activates	cell_type	0.85
Depression	protects_against	disease	0.85
Oxidative Stress	associated_with	process	0.85
Type 2 Diabetes	treats	disease	0.85
Sarcopenia	treats	disease	0.85
BDNF	associated_with	protein	0.85
Mitochondrial Function	associated_with	process	0.85
Amyloid-Beta Toxicity	associated_with	process	0.85
Osteoporosis	protects_against	disease	0.85
Alzheimer's Disease	treats	disease	0.80
Human Umbilical Vein Endothelial Cells	modulates	cell_type	0.80
AMPK	activates	protein	0.80
neurodegeneration	protects_against	process	0.80
cognition	promotes	phenotype	0.80
Neurodegenerative Diseases	protects_against	disease	0.75
Alzheimer's disease	protects_against	disease	0.70

Incoming (21)

Source	Relation	Type	Str
FNDC5	encodes	gene	1.00
FNDC5	encodes	gene	1.00
integrin αV/β5	interacts_with	protein	0.70
DEPRESSION	activates	disease	0.50
BDNF	activates	gene	0.50
IL-6	activates	protein	0.50
IL-1Β	activates	protein	0.50
ALZHEIMER	activates	gene	0.50
BDNF	co_discussed	gene	0.50
FGF21	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50
HEPSIN	co_discussed	protein	0.50
STAT3	activates	gene	0.50
FNDC5	activates	gene	0.50
FNDC5	associated_with	gene	0.50
FGF21	activates	gene	0.50
SPARC	activates	protein	0.50
VEGF	activates	gene	0.50
BMP2	activates	gene	0.50
PDGFRB	activates	gene	0.50
VEGFB	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IRISIN in their description or question text

No additional research found