gene

RAD18

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAD18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

56Connections

0Hypotheses

0Analyses

45Outgoing

11Incoming

0Experiments

0Debates

Summary

RAD18 E3 ubiquitin protein ligase involved in translesion DNA synthesis and DNA damage tolerance.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	RAD18
Full Name	RAD18 E3 Ubiquitin Protein Ligase
Chromosome	9q31.1
Protein Type	Ligase
Function	is a key DNA damage response protein that plays a critical role in maintaining genome stability through translesion DNA synthesis (TLS).
Pathways	DNA Damage Response
UniProt ID	[Q9NS91](https://www.uniprot.org/uniprotkb/Q9NS91/entry)
GeneCards	RAD18
Human Protein Atlas	RAD18
RING finger domain	A C3HC4-type RING finger motif that facilitates E3 ubiquitin ligase activity[@takizawa2010]
UBZ domain	A ubiquitin-binding zinc finger domain that recognizes ubiquitinated PCNA
RAD6 interaction domain	Region required for binding to RAD6A/B ubiquitin-conjugating enzymes
PCNA-binding domain	motif for direct interaction with PCNA at replication forks
Associated Diseases	Als
Interactions	Actin, AND, BRCA1, DNA, GBM, GLIOBLASTOMA
KG Connections	56 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RAD18 Gene

gene · 1510 words

→

RAD18 Protein — DNA Damage Repair and Translesion Synthesis

protein · 1138 words

→

Pathway Diagram

graph TD
    RAD18["RAD18"]
    Als{"Als"}
    RAD18 -->|"associated with"| Als
    Ms{"Ms"}
    RAD18 -->|"activates"| Ms
    Glioblastoma{"Glioblastoma"}
    RAD18 -->|"activates"| Glioblastoma
    IRF3["IRF3"]
    RAD18 -->|"activates"| IRF3
    OPTN["OPTN"]
    RAD18 -->|"activates"| OPTN
    UBIQUITIN["UBIQUITIN"]
    RAD18 -->|"therapeutic target"| UBIQUITIN
    RAD18 -->|"activates"| UBIQUITIN
    neurodegeneration["neurodegeneration"]
    RAD18 -->|"implicated in"| neurodegeneration
    OPTN -->|"activates"| RAD18
    GBM["GBM"]
    GBM -->|"activates"| RAD18
    style RAD18 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (45)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Als	degrades	disease	0.65
Ms	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Als	associated_with	disease	0.65
DNA	interacts_with	gene	0.60
IRF3	activates	gene	0.60
Nk Cell	activates	cell_type	0.60
TRIM28	interacts_with	gene	0.60
NEIL1	therapeutic_target	gene	0.60
DNA	activates	gene	0.60
T Cell	activates	cell_type	0.60
Actin	interacts_with	protein	0.60
T Cell	inhibits	cell_type	0.60
Raf	degrades	protein	0.60
T Cell	interacts_with	cell_type	0.60
Ras	interacts_with	protein	0.60
Ubiquitin-Proteasome	activates	pathway	0.60
Actin	activates	protein	0.60
Ras	activates	protein	0.60
Proteasome	activates	protein	0.60
T Cell	expressed_in	cell_type	0.60
Macrophage	expressed_in	cell_type	0.60
DNA	inhibits	gene	0.60
APOPTOSIS	regulates	gene	0.60
Stem Cell	activates	cell_type	0.60
RAF	expressed_in	gene	0.60
Ras	expressed_in	protein	0.60
OPTN	activates	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
PALB2	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
RAD51	interacts_with	gene	0.60
GBM	activates	gene	0.60
UBIQUITIN	degrades	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
BRCA1	interacts_with	gene	0.60
E2F7	expressed_in	gene	0.60
UBIQUITIN	associated_with	gene	0.60

Incoming (11)

Source	Relation	Type	Str
UBIQUITIN	activates	gene	0.60
GBM	activates	gene	0.60
BRAF	regulates	gene	0.60
DNA	interacts_with	gene	0.60
RNA	activates	gene	0.60
DNA	activates	gene	0.60
RAS	expressed_in	gene	0.60
KRAS	regulates	gene	0.60
OPTN	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAD18 in their description or question text

No additional research found