| Gene Symbol | BAP1 |
| Full Name | BRCA1-Associated Protein 1 |
| Chromosome | 3p21.1 |
| Protein Type | Hydrolase |
| Function | encodes a nuclear deubiquitinase (DUB) of the ubiquitin C-terminal hydrolase (UCH) family that plays essential roles in chromatin regulation, DNA damage response, and cell fate determination. |
| Primary Expression | tyrosine hydroxylase-positive dopaminergic neurons |
| Pathways | Epigenetic, Ferroptosis |
| UniProt ID | [Q92560](https://www.uniprot.org/uniprot/Q92560) |
| Ensembl ID | ENSG00000163930 |
| GeneCards | BAP1 |
| Human Protein Atlas | BAP1 |
| DNA damage response | BAP1 is rapidly recruited to DNA double-strand breaks where it deubiquitinates H2AK119 to facilitate homologous recombination repair and checkpoint activation |
| Metabolic regulation | BAP1 regulates calcium signaling through the IP3 receptor, linking chromatin remodeling to cellular metabolic state |
| Cell death regulation | BAP1 promotes ferroptosis by repressing SLC7A11 (the cystine/glutamate antiporter), thereby modulating oxidative stress sensitivity |
| Associated Diseases | Als, Cancer, Carcinoma, Melanoma, Ovarian Cancer |
| Interactions | BRCA1, FERROPTOSIS, SLC7A11, UBIQUITIN |
| KG Connections | 37 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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