gene

BAP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

29Outgoing

8Incoming

0Experiments

0Debates

Summary

BAP1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, activates. Associated with Als, Cancer, Carcinoma. Connected to 32 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BAP1
Full Name	BRCA1-Associated Protein 1
Chromosome	3p21.1
Protein Type	Hydrolase
Function	encodes a nuclear deubiquitinase (DUB) of the ubiquitin C-terminal hydrolase (UCH) family that plays essential roles in chromatin regulation, DNA damage response, and cell fate determination.
Primary Expression	tyrosine hydroxylase-positive dopaminergic neurons
Pathways	Epigenetic, Ferroptosis
UniProt ID	[Q92560](https://www.uniprot.org/uniprot/Q92560)
Ensembl ID	ENSG00000163930
GeneCards	BAP1
Human Protein Atlas	BAP1
DNA damage response	BAP1 is rapidly recruited to DNA double-strand breaks where it deubiquitinates H2AK119 to facilitate homologous recombination repair and checkpoint activation
Metabolic regulation	BAP1 regulates calcium signaling through the IP3 receptor, linking chromatin remodeling to cellular metabolic state
Cell death regulation	BAP1 promotes ferroptosis by repressing SLC7A11 (the cystine/glutamate antiporter), thereby modulating oxidative stress sensitivity
Associated Diseases	Als, Cancer, Carcinoma, Melanoma, Ovarian Cancer
Interactions	BRCA1, FERROPTOSIS, SLC7A11, UBIQUITIN
KG Connections	37 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BAP1["BAP1"]
    Ms{"Ms"}
    BAP1 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    BAP1 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    BAP1 -->|"inhibits"| Tumor
    FERROPTOSIS["FERROPTOSIS"]
    BAP1 -->|"inhibits"| FERROPTOSIS
    CANCER["CANCER"]
    BAP1 -->|"associated with"| CANCER
    BRCA1["BRCA1"]
    BAP1 -->|"inhibits"| BRCA1
    SLC7A11["SLC7A11"]
    BAP1 -->|"inhibits"| SLC7A11
    Ferroptosis(["Ferroptosis"])
    BAP1 -->|"inhibits"| Ferroptosis
    Epigenetic(["Epigenetic"])
    BAP1 -->|"inhibits"| Epigenetic
    BAP1 -->|"activates"| FERROPTOSIS
    BAP1 -->|"activates"| SLC7A11
    ATF4["ATF4"]
    BAP1 -->|"regulates"| ATF4
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"activates"| BAP1
    style BAP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.85
Als	associated_with	disease	0.75
BRCA1	interacts_with	gene	0.70
Ovarian Cancer	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Pancreatic Cancer	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Renal Cell Carcinoma	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
DNA	associated_with	gene	0.60
BRCA1	inhibits	gene	0.60
SLC7A11	inhibits	gene	0.60
BRCA1	expressed_in	gene	0.60
BRCA1	regulates	gene	0.60
ALS	associated_with	disease	0.60
DNA	regulates	gene	0.60
SLC7A11	activates	gene	0.60
ATF4	regulates	gene	0.60
NRF2	regulates	gene	0.60
Epigenetic	inhibits	pathway	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
FERROPTOSIS	inhibits	gene	0.60
POT1	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
Ferroptosis	inhibits	pathway	0.60
PARP1	co_expressed_with	gene	0.50

Incoming (8)

Source	Relation	Type	Str
CANCER	associated_with	gene	0.70
PTEN	associated_with	gene	0.70
CDKN2A	associated_with	gene	0.70
BRCA1	associated_with	gene	0.60
MITF	associated_with	gene	0.60
CDK4	associated_with	gene	0.60
GENES	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BAP1 in their description or question text

No additional research found