Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BRCA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | BRCA |
| Key Genes/Proteins | BRCA1, CD4, DNA, DOT1L, HCRTR1, HCRTR2 |
| Related Diseases | Als, cancer, Cancer, cardiovascular disease |
| Related Pathways | oxidative stress response |
Knowledge base pages for this entity
graph TD
BRCA[BRCA]
BRCA -->|expressed in| Cancer[Cancer]
BRCA -->|regulates| Als[Als]
BRCA -->|expressed in| HCRTR1[HCRTR1]
BRCA -->|regulates| Rb[Rb]
BRCA -->|expressed in| DOT1L[DOT1L]
BRCA -->|inhibits| cancer[cancer]
BRCA -->|inhibits| BRCA1[BRCA1]
BRCA -->|activates| DNA[DNA]
HCRTR2[HCRTR2] -->|expressed in| BRCA
CD4[CD4] -->|expressed in| BRCA
benchmark_ot_ad_answer_key_BRC[benchmark_ot_ad_answer_key:BRCA] -->|data_in| BRCA| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:BRCA | data_in | dataset_row | 0.00 |
| Parp Inhibitor Response | associated_with | phenotype | 0.75 |
| Cancer | expressed_in | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| DNA | activates | gene | 0.60 |
| Ras | activates | protein | 0.60 |
| DOT1L | expressed_in | gene | 0.60 |
| Rb | regulates | protein | 0.60 |
| cancer | inhibits | disease | 0.60 |
| KEAP1 | associated_with | gene | 0.60 |
| NRF2 | associated_with | gene | 0.60 |
| cardiovascular disease | associated_with | disease | 0.60 |
| PTPN11 | associated_with | gene | 0.60 |
| BRCA1 | inhibits | gene | 0.60 |
| BRCA1 | interacts_with | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| HCRTR1 | expressed_in | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:BRCA | data_in | dataset_row | 0.00 |
| HCRTR2 | expressed_in | gene | 0.60 |
| CD4 | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BRCA in their description or question text
No additional research found