gene 846 words KG: BRCA1
Contents

BRCA1 Gene

🧬 Gene Info
Gene SymbolBRCA1
Full NameBRCA1 DNA Repair Associated
Chromosome17q21
FunctionBRCA1 is a key component of the DNA damage response machinery
Primary Expressionmost tissues with high expression in: - Breast and ovarian epithelium - Testis - Brain (neurons and glia) - Proliferating cells
PathwaysApoptosis, Autophagy, Cell Cycle, Dna Repair, Immune Response
UniProt IDP38398
NCBI Gene ID672
Ensembl IDENSG00000012048
OMIM113705
GeneCardsBRCA1
Human Protein AtlasBRCA1
Associated DiseasesAls, Breast Cancer, Cancer, Carcinoma, Melanoma
InteractionsABHD12, Actin, AND, APOPTOSIS, ARC, ATG3
KG Connections455 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
PARP1 Inhibition Therapy
Score: 0.74
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (13)

ATP P2X3 Receptor Neurons
cell · KG edge: inhibits
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: expressed_in
Apoptosis in Neurodegeneration
entity · KG edge: implicated_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ABHD12 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

SOX2 biomarker_for BRCA1
ATM associated_with BRCA1
GAIN biomarker_for BRCA1
OVERVIEW biomarker_for BRCA1
BRCA1 biomarker_for EZH2
GABARAP associated_with BRCA1
WIPI2 associated_with BRCA1
PIK3C3 associated_with BRCA1
OPTN associated_with BRCA1
TFEB associated_with BRCA1

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