| Gene Symbol | BRCA1 |
| Full Name | BRCA1 DNA Repair Associated |
| Chromosome | 17q21 |
| Function | BRCA1 is a key component of the DNA damage response machinery |
| Primary Expression | most tissues with high expression in: - Breast and ovarian epithelium - Testis - Brain (neurons and glia) - Proliferating cells |
| Pathways | Apoptosis, Autophagy, Cell Cycle, Dna Repair, Immune Response |
| UniProt ID | P38398 |
| NCBI Gene ID | 672 |
| Ensembl ID | ENSG00000012048 |
| OMIM | 113705 |
| GeneCards | BRCA1 |
| Human Protein Atlas | BRCA1 |
| RING Domain | E3 ubiquitin ligase activity at N-terminus |
| BRCT Domains | Two tandem breast cancer C-terminal domains for DNA binding |
| coiled-coil Domain | Interaction with PALB2 and BRCA2 |
| Associated Diseases | Als, Breast Cancer, Cancer, Carcinoma, Melanoma |
| Interactions | ABHD12, Actin, APOPTOSIS, ARC, ATG3, ATG4B |
| KG Connections | 451 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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