protein

BRCA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRCA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

166Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

BRCA2 is a protein involved in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with Aging, Als, Anxiety. Connected to 117 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BRCA2
Full Name	BRCA2 DNA Repair Associated
Chromosome	13q13.1
Function	The BRCA2 gene encodes BRCA2 DNA Repair Associated, involved in DNA repair and genomic stability
Molecular Weight	384 kDa
Pathways	Autophagy, Ferroptosis, Homologous Recombination, Innate Immunity, Oxidative Stress
UniProt ID	BRCA2
NCBI Gene ID	675
Ensembl ID	ENSG00000139618
OMIM	600185
GeneCards	BRCA2
Human Protein Atlas	BRCA2
DNA repair	Critical for maintaining genomic integrity
Cell cycle regulation	Coordinates DNA repair with cell cycle progression
[Apoptosis](/entities/apoptosis)	Modulates apoptotic response to DNA damage
Associated Diseases	Als, Breast Cancer, Cancer, Carcinoma
Interactions	AND, APOPTOSIS, ATM, AUTOPHAGY, BRCA1, CANCER
KG Connections	166 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BRCA2["BRCA2"] -->|"activates"| Carcinoma["Carcinoma"]
    BRCA2["BRCA2"] -->|"activates"| Ms["Ms"]
    BRCA2["BRCA2"] -->|"activates"| Tumor["Tumor"]
    BRCA2["BRCA2"] -->|"therapeutic target"| Aging["Aging"]
    BRCA2["BRCA2"] -->|"therapeutic target"| Ms_1["Ms"]
    BRCA2["BRCA2"] -->|"regulates"| Aging_2["Aging"]
    LC3["LC3"] -->|"activates"| BRCA2["BRCA2"]
    LC3B["LC3B"] -->|"activates"| BRCA2["BRCA2"]
    P62["P62"] -->|"activates"| BRCA2["BRCA2"]
    TRIM25["TRIM25"] -->|"activates"| BRCA2["BRCA2"]
    style BRCA2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (93)

Target	Relation	Type	Str
Cancer	associated_with	disease	1.00
CANCER	associated_with	gene	0.80
Tumor	activates	disease	0.75
Als	expressed_in	disease	0.75
Breast Cancer	associated_with	disease	0.75
Carcinoma	activates	disease	0.75
GENES	associated_with	gene	0.70
PARP1	inhibits	gene	0.70
Neurodegeneration	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Longevity	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Prostate Cancer	treats	disease	0.65
Cancer	inhibits	disease	0.65
Aging	treats	disease	0.65
Ms	regulates	disease	0.65
Ms	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Anxiety	expressed_in	disease	0.65
Depression	expressed_in	disease	0.65
Als	biomarker_for	disease	0.65
Ataxia	regulates	disease	0.65
Cancer	biomarker_for	disease	0.65
Tumor	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	inhibits	disease	0.65
Als	implicated_in	disease	0.65
FERROPTOSIS	modifies	phenotype	0.65
Carcinoma	implicated_in	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
HMGCR	modifies	gene	0.65
FERROPTOSIS	inhibits	phenotype	0.65
Cancer	activates	disease	0.65
Renal Cell Carcinoma	activates	disease	0.65
Aging	regulates	disease	0.65
Immune Checkpoint	treats	pathway	0.60
DEPRESSION	expressed_in	gene	0.60
CANCER	biomarker_for	gene	0.60
Akt	biomarker_for	pathway	0.60
Pi3K	biomarker_for	pathway	0.60
GENE MUTATIONS	associated_with	gene	0.60
Homologous Recombination	activates	pathway	0.60
APOPTOSIS	inhibits	gene	0.60
Autophagy	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Pyroptosis	activates	pathway	0.60
CDH1	associated_with	gene	0.60

Incoming (73)

Source	Relation	Type	Str
BRCA1	associated_with	gene	0.90
CANCER	associated_with	gene	0.70
TP53	associated_with	gene	0.70
KRAS	associated_with	gene	0.70
BRCA1	protects_against	gene	0.60
AGING	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
P53	regulates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
PYROPTOSIS	activates	gene	0.60
BRCA1	inhibits	gene	0.60
AND	activates	gene	0.60
BRCA1	interacts_with	gene	0.60
AGING	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
CDH1	regulates	gene	0.60
GENES	associated_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ANXIETY	expressed_in	gene	0.60
AND	associated_with	gene	0.60
FOXP1	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
PTEN	associated_with	gene	0.60
TP53	expressed_in	gene	0.60
PTEN	expressed_in	gene	0.60
PI3K	biomarker_for	gene	0.60
CD38	therapeutic_target	gene	0.60
SIRT6	regulates	gene	0.60
PARP1	regulates	gene	0.60
HNRNPA1	activates	gene	0.60
MYC	regulates	gene	0.60
DDX5	activates	gene	0.60
PIN1	regulates	gene	0.60
BRCA1	regulates	gene	0.60
ATR	regulates	gene	0.60
HNRNPH1	activates	gene	0.60
CDKN2A	associated_with	gene	0.60
MLH1	associated_with	gene	0.60
PALB2	associated_with	gene	0.60
ATM	associated_with	gene	0.60
ATM	regulates	gene	0.60
TP53	regulates	gene	0.60
NBN	regulates	gene	0.60
BRIP1	regulates	gene	0.60
STK11	regulates	gene	0.60
CHEK2	regulates	gene	0.60
PTEN	regulates	gene	0.60
PALB2	regulates	gene	0.60
RAD51	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity