protein 918 words KG: BECLIN1
Contents

Beclin 1 (BECN1)

🔬 Protein Info
Gene SymbolBECLIN1
Full NameBECN1
Protein TypeGene
Functionis a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis
PathwaysApoptosis, Autophagy, Mtor, Oxidative Stress
GeneCardsBECLIN1
Human Protein AtlasBECLIN1
Associated DiseasesAls, Alzheimer, Cancer, Colorectal Cancer, Glioblastoma, Inflammation
InteractionsABCA1, ACTB, ADSL, AKT, AKT1, ALZHEIMER
KG Connections622 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (18)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
APOE-Dependent Autophagy Restoration
Score: 0.85
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (8)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
ACTB Gene
gene · KG edge: activates
AKT1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CHOP regulates BECLIN1
FIS1 associated_with BECLIN1
VEGF associated_with BECLIN1
BAX associated_with BECLIN1
TRAF6 associated_with BECLIN1
CHOP associated_with BECLIN1
NRF2 associated_with BECLIN1
MTOR associated_with BECLIN1
BECLIN1 associated_with BCL2
BECLIN1 associated_with TAAR1

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