gene

SCN2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCN2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

24Outgoing

12Incoming

0Experiments

0Debates

Summary

SCN2A is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Ataxia, Ms, Parkinson. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SCN2A
Full Name	Sodium Voltage-Gated Channel Alpha Subunit 2
Aliases	Nav1.2 (Sodium channel voltage-gated alpha subunit 2)
Chromosome	2q24.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Cerebral cortex, Hippocampus, Cerebellum
Subcellular Localization	the axon initial segment (AIS) and nodes of Ranvier, where it plays a crucial role in action potential initiation and pr
Amino Acids	2000 aa
UniProt ID	O43526
NCBI Gene ID	6325
Ensembl ID	ENSG00000136531
OMIM	182390
GeneCards	SCN2A
Human Protein Atlas	SCN2A
Associated Diseases	Ataxia, autism spectrum disorder, Ms, Parkinson
KG Connections	36 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SCN2A — AlphaFold O43526 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SCN2A — Sodium Voltage-Gated Channel Alpha Subunit 2

gene · 1296 words

→

Nav1.2 Sodium Channel (SCN2A)

protein · 836 words

→

Pathway Diagram

graph TD
    SCN2A["SCN2A"]
    Parkinson{"Parkinson"}
    SCN2A -->|"associated with"| Parkinson
    Ms{"Ms"}
    SCN2A -->|"associated with"| Ms
    Ataxia{"Ataxia"}
    SCN2A -->|"associated with"| Ataxia
    APOPTOSIS["APOPTOSIS"]
    SCN2A -->|"associated with"| APOPTOSIS
    SCN4A["SCN4A"]
    SCN2A -->|"therapeutic target"| SCN4A
    GBA["GBA"]
    SCN2A -->|"therapeutic target"| GBA
    Apoptosis(["Apoptosis"])
    SCN2A -->|"associated with"| Apoptosis
    Akt(["Akt"])
    SCN2A -->|"therapeutic target"| Akt
    neurodegeneration["neurodegeneration"]
    SCN2A -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| SCN2A
    DOCK2["DOCK2"]
    DOCK2 -->|"associated with"| SCN2A
    SCN8A["SCN8A"]
    SCN8A -->|"therapeutic target"| SCN2A
    AKT1["AKT1"]
    AKT1 -->|"therapeutic target"| SCN2A
    style SCN2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

Target	Relation	Type	Str
Ataxia	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Apoptosis	associated_with	pathway	0.60
AKT1	therapeutic_target	gene	0.60
Akt	therapeutic_target	pathway	0.60
DOCK2	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
autophagy pathway	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
stem cells	expressed_in	cell_type	0.60
autism spectrum disorder	causes	disease	0.60
autism spectrum disorder	associated_with	disease	0.60
microglia	expressed_in	cell_type	0.60
autism spectrum disorder	interacts_with	disease	0.60
SCN4A	therapeutic_target	gene	0.60
GBA	therapeutic_target	gene	0.60
SCN8A	associated_with	gene	0.60
STXBP1	associated_with	gene	0.60
WWOX	associated_with	gene	0.60
SYNGAP1	targets	gene	0.60
AND	therapeutic_target	gene	0.60
PARKINSON	associated_with	gene	0.60
SYNAPSE	associated_with	gene	0.60

Incoming (12)

Source	Relation	Type	Str
SCN1A	associated_with	gene	0.60
DOCK2	associated_with	gene	0.60
SCN8A	therapeutic_target	gene	0.60
AKT1	therapeutic_target	gene	0.60
GBA	therapeutic_target	gene	0.60
CDKL5	associated_with	gene	0.60
HCN1	associated_with	gene	0.60
KCNQ2	associated_with	gene	0.60
PLCB1	associated_with	gene	0.60
DYRK1A	targets	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
HIPPOCAMPUS	associated_with	brain_region	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SCN2A in their description or question text

No additional research found