gene

ATXN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATXN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

26Outgoing

2Incoming

0Experiments

0Debates

Summary

Gene profile: ATXN1

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🧬 Gene Info

Gene Symbol	ATXN1
Full Name	Ataxin 1
Chromosome	6p22.3.
Function	Capicua (CIC) repressor complex — Ataxin-1 binds to the transcriptional repressor CIC, regulating downstream target genes
Molecular Weight	87 kDa
Amino Acids	815 aa
Pathways	Notch signaling
UniProt ID	P54253
GeneCards	ATXN1
Human Protein Atlas	ATXN1
Associated Diseases	Ataxia, Huntington's disease, neurodegeneration
Interactions	BDNF, CIC, NEURON, PKA
KG Connections	28 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ATXN1 — AlphaFold P54253 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    ATXN1(["ATXN1"])
    Ataxia["Ataxia"]
    Neurodegeneration["Neurodegeneration"]
    BDNF(["BDNF"])
    CAG_REPEATS(["CAG REPEATS"])
    NEURON(["NEURON"])
    NEURODEGENERATION(["NEURODEGENERATION"])
    neurodegeneration["neurodegeneration"]

    ATXN1 -->|"causes"| Ataxia
    ATXN1 -->|"expressed in"| Neurodegeneration
    ATXN1 -->|"activates"| BDNF
    ATXN1 -->|"causes"| CAG_REPEATS
    ATXN1 -.->|"inhibits"| NEURON
    NEURODEGENERATION -->|"expressed in"| ATXN1
    BDNF -.->|"inhibits"| ATXN1
    ATXN1 -->|"implicated in"| neurodegeneration

    style ATXN1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (26)

Target	Relation	Type	Str
neurodegeneration	causes	disease	0.90
CIC	interacts_with	gene	0.80
neurons	expressed_in	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
Huntington's disease	causes	disease	0.80
Ataxia	causes	disease	0.75
stem cells	expressed_in	cell_type	0.70
ATXN2	causes	gene	0.70
Neurodegeneration	expressed_in	disease	0.65
PKA	regulates	gene	0.60
PKA	activates	gene	0.60
PKA	associated_with	gene	0.60
multiple sclerosis	regulates	disease	0.60
BDNF	activates	gene	0.60
CAG REPEATS	causes	gene	0.60
NEURON	inhibits	gene	0.60
mitochondrial function	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
PKA	phosphorylates	gene	0.60
RAN	expressed_in	gene	0.60
ATXN2	associated_with	gene	0.60
NIPA1	associated_with	gene	0.60
UNC13A	associated_with	gene	0.60
neurodegeneration	interacts_with	disease	0.60
CIC	causes	gene	0.60
ATXN3	causes	gene	0.60

Incoming (2)

Source	Relation	Type	Str
NEURODEGENERATION	expressed_in	gene	0.60
BDNF	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATXN1 in their description or question text

No additional research found